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GlossaryAndrogenetic Alopecia (ADM)

genetic hair loss influenced by androgens, often hereditary

Androgenetic Alopecia, commonly known as Male Pattern Baldness or Female Pattern Baldness, is a genetic condition characterized by progressive hair thinning and loss. It is influenced by androgens (male hormones) and typically follows a recognizable pattern, such as a receding hairline in men and diffuse thinning on the crown in women. This condition is the most common cause of hair loss, affecting both genders, and is often hereditary.

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research Admixture in Latin America: Geographic Structure, Phenotypic Diversity, and Self-Perception of Ancestry Based on 7,342 Individuals

340 citations, September 2014 in “PLOS Genetics”

The study found that in Latin America, ancestry varies by location, influences physical traits, and affects how people perceive their own heritage.

research Decreased Fertility in Male Rats Administered the 5α-Reductase Inhibitor, Finasteride, Due to Deficits in Copulatory Plug Formation

37 citations, January 1991 in “Reproductive Toxicology”

Finasteride reduces male rat fertility by causing issues with copulatory plug formation.

ADM Scaffolds Generate a Pro-Regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1

research ADM Scaffolds Generate a Pro-Regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1

17 citations, June 2018 in “Frontiers in Physiology”

ADM scaffolds help skin heal by promoting a healing-type immune response.

research Molecular Docking Studies and ADME-Tox Prediction of Phytocompounds from Merremia Peltata as a Potential Anti-Alopecia Treatment

7 citations, April 2021 in “Journal of advanced pharmaceutical technology & research”

The compound 16 from the Merremia peltata plant could potentially be a good treatment for hair loss (alopecia) due to its strong activity and favorable skin absorption.

Administration of Caesalpinia Bonduc Seed Extracts Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia in Male Wistar Rats

research Administration of Caesalpinia Bonduc Seed Extracts Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia in Male Wistar Rats

6 citations, May 2022 in “Research and reports in urology”

Caesalpinia bonduc seed extracts may help treat enlarged prostate in rats.

research Administration of Nrf-2-Modified Hair-Follicle MSCs Ameliorates DSS-Induced Ulcerative Colitis in Rats

3 citations, January 2021 in “Oxidative Medicine and Cellular Longevity”

Nrf-2-modified stem cells from hair follicles significantly improve ulcerative colitis in rats.

Administration of 45% Robusta Green Coffee Bean Ethanol Extract Solution and Its Effects on Hair Growth and 5α-Reductase Type 1 Levels in Male Wistar Rats

research Administration of 45% Robusta Green Coffee Bean Ethanol Extract Solution and Its Effects on Hair Growth and 5α-Reductase Type 1 Levels in Male Wistar Rats

July 2023 in “International journal of research publications”

Green coffee bean extract didn't grow hair but reduced a hair loss-related enzyme in rats.

research Administration of Dutasteride in Animal Models of Retinitis Pigmentosa

December 2022 in “Acta Ophthalmologica”

Dutasteride potentially improves cell survival and reduces retinal damage in retinitis pigmentosa.

research Pulsed Administration of Corticosteroids in the Treatment of Alopecia Areata

117 citations, February 1996 in “International Journal of Dermatology”

A 300 mg monthly pulse of prednisolone effectively and safely treats widespread alopecia areata.

research French Administrative Health Care Database (SNDS): The Value of Its Enrichment

64 citations, October 2018 in “Thérapie”

Enriching the French health care database with external data greatly improved its usefulness.

research Niosomes as a Vesicular Carrier for Topical Administration of Minoxidil: Formulation and In Vitro Assessment

48 citations, December 2013 in “Drug Delivery and Translational Research”

Niosomes improve minoxidil skin penetration for hair loss treatment.

research Neonatal Finasteride Induces Anxiogenic-Like Profile and Deteriorates Passive Avoidance in Adulthood After Intrahippocampal Neurosteroid Administration

27 citations, July 2008 in “Neuroscience”

Finasteride given to baby rats causes anxiety-like behavior and worsens learning from punishment in adult rats.

Chronic Administration of Minoxidil Protects Elastic Fibers and Stimulates Their Neosynthesis with Improvement of the Aorta Mechanics in Mice

research Chronic Administration of Minoxidil Protects Elastic Fibers and Stimulates Their Neosynthesis with Improvement of the Aorta Mechanics in Mice

17 citations, June 2019 in “Cellular signalling”

Minoxidil helps protect and rebuild elastic fibers in arteries, improving artery function, especially in older females.

Oral Administration of Low-Dose Bisphenol A Promotes Proliferation of Ventral Prostate and Upregulates Prostaglandin D2 Synthase Expression in Adult Rats

research Oral Administration of Low-Dose Bisphenol A Promotes Proliferation of Ventral Prostate and Upregulates Prostaglandin D2 Synthase Expression in Adult Rats

14 citations, July 2016 in “Toxicology and Industrial Health”

Low doses of BPA can increase prostate growth and change hormone levels in adult rats.

The Administration of Flumethasone by Three Different Routes, Its Measurement in the Plasma, and Some Effects on Wool Growth in Merino Wethers

research The Administration of Flumethasone by Three Different Routes, Its Measurement in the Plasma, and Some Effects on Wool Growth in Merino Wethers

9 citations, January 1978 in “Australian Journal of Biological Sciences”

Flumethasone causes wool shedding in Merino wethers, with recovery in about 60 days.

research Co-Administration of 5α-Reductase Inhibitors Worsens the Adverse Metabolic Effects of Prescribed Glucocorticoids

8 citations, June 2020 in “The Journal of Clinical Endocrinology and Metabolism”

Taking 5α-reductase inhibitors with prednisolone can worsen its negative effects on metabolism.

research Finasteride Administration Potentiates the Disruption of Prepulse Inhibition Induced by Forced Swim Stress

6 citations, April 2015 in “Behavioural Brain Research”

Finasteride worsens stress effects on sensory processes, possibly linking to anxiety/depression.

Neonatal Finasteride Administration Decreases Dopamine Release in Nucleus Accumbens After Alcohol and Food Presentation in Adult Male Rats

research Neonatal Finasteride Administration Decreases Dopamine Release in Nucleus Accumbens After Alcohol and Food Presentation in Adult Male Rats

3 citations, August 2016 in “Behavioural Brain Research”

Finasteride given to baby rats reduces dopamine release and increases alcohol consumption in adult males.

Evaluation of the Safety and Effectiveness of Intradermal Administration of QR678 Neo Hair Growth Factor Formulation: A Phase-IV, Open-Label, Single-Arm Multi-Ethnicity Clinical Trial

research Evaluation of the Safety and Effectiveness of Intradermal Administration of QR678 Neo Hair Growth Factor Formulation: A Phase-IV, Open-Label, Single-Arm Multi-Ethnicity Clinical Trial

2 citations, January 2022 in “Journal of Cosmetic Dermatology”

QR678 Neo® is a safe and effective treatment for hair loss in men and women.

research Stem Cells as a Target for the Delivery of Active Molecules to Skin by Topical Administration

2 citations, March 2020 in “International Journal of Molecular Sciences”

Topical treatments can deliver active molecules to skin stem cells, potentially helping treat skin and hair disorders, including skin cancers and hair loss.

research Food Administration and Not Genetic Variants Causes Pharmacokinetic Variability of Tadalafil and Finasteride

1 citations, October 2023 in “Journal of personalized medicine”

Food intake, not genetics, affects how the body processes tadalafil and finasteride.

research The Administration of Ocoxin Increases the Quality of Life of Patients with Advanced Epithelial or Metastatic Ovarian Cancer Undergoing Neoadjuvant Chemotherapy

1 citations, January 2022 in “Journal of Cancer Therapy”

Ocoxin improves quality of life for advanced ovarian cancer patients on chemotherapy.

research Local Stimulation of Sebaceous Gland Activity by the Topical Administration of Dehydroepiandrosterone

1 citations, January 1988

Topical DHEA safely increases skin oil production.

research Cedrol in Ginger (Zingiber Officinale) as a Promising Hair Growth Drug: The Effects of Oral and External Administration on Hair Regeneration and Its Mechanism

August 2024 in “Bioorganic Chemistry”

Cedrol from ginger can promote hair growth when taken orally.

research Oral Administration of Lactilactobacillus Curvatus LB-P9 Promotes Hair Regeneration in Mice

November 2023 in “Food science of animal resources”

Lactilactobacillus curvatus LB-P9 taken orally helps hair regrow faster and thicker in mice.

Oral and Topical Administration of Standardized Saw Palmetto Oil Reduces Hair Fall and Improves Hair Growth in Androgenetic Alopecia Subjects: A 16-Week Randomized, Placebo-Controlled Study

research Oral and Topical Administration of Standardized Saw Palmetto Oil Reduces Hair Fall and Improves Hair Growth in Androgenetic Alopecia Subjects: A 16-Week Randomized, Placebo-Controlled Study

November 2023 in “Clinical, Cosmetic and Investigational Dermatology”

Saw palmetto extract reduced hair loss and improved hair growth in people with hair thinning.

Simultaneous Determination of Three Flavonoids in Rat Plasma of Masson Pinus Needles (Pinus Massoniana L.) Extracts by UHPLC-MS/MS and Application to Pharmacokinetics Studies After Oral and Transdermal Administration

research Simultaneous Determination of Three Flavonoids in Rat Plasma of Masson Pinus Needles (Pinus Massoniana L.) Extracts by UHPLC-MS/MS and Application to Pharmacokinetics Studies After Oral and Transdermal Administration

August 2023 in “Journal of Chromatographic Science”

A new method accurately measures three compounds in rat plasma from pine needle extracts, aiding future research on its use for hair loss.

research Oral Administration of TrkB Agonist, 7,8-Dihydroxyflavone Regenerates Hair Cells and Restores Function after Gentamicin-Induced Vestibular Injury in Guinea Pig

February 2023 in “Pharmaceutics”

Clinical Evaluation of Intradermal Platelet-Rich Plasma Administration Along with Oral Biotin Supplement for the Management of Androgenetic Alopecia in Adult Males: A Randomized Clinical Trial

research Clinical Evaluation of Intradermal Platelet-Rich Plasma Administration Along with Oral Biotin Supplement for the Management of Androgenetic Alopecia in Adult Males: A Randomized Clinical Trial

January 2022 in “Journal of Clinical and Diagnostic Research”

Using platelet-rich plasma injections and biotin pills together significantly increases hair regrowth in men with hair loss.

research Epigallocatechin Gallate and Tannic Acid Based Formulations of Finasteride for Dermal Administration and Chemoembolization

October 2020 in “Journal of Pharmaceutical Sciences”

Topical finasteride with EGCG or TA improves drug release and dermal uptake, potentially treating hair loss effectively.