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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Different types of skin cells play specific roles in development, healing, and cancer.

Men are more likely to have severe COVID-19 cases and fatalities than women due to factors like lifestyle, aging, and biological differences.

Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.

Macrophages help heal nerves by aiding the maturation of Schwann cells and are important for nerve repair.

Fat cells in the skin help start healing and form important repair cells after injury.

Pregnancy can increase lupus activity, but careful planning and treatment can improve outcomes.

Different types of fibroblasts play various roles in both healthy and diseased tissues, and understanding them better could improve treatments for fibrotic diseases.

Eph/ephrin signaling is important for skin cell behavior and could be targeted to treat skin diseases.

The hair follicle infundibulum plays a key role in skin health and disease, and understanding it better could lead to new skin disease treatments.

Skin and hair can regenerate after injury due to changes in gene activity, with potential links to how cancer spreads. Future research should focus on how new hair follicles form and the processes that trigger their creation.

Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

Blood tests can help understand the genetic differences in people with alopecia areata, including how severe it is and if it's inherited.

The study found stem cells in minor salivary glands that can differentiate and are involved in tumor formation when exposed to tobacco.

Canine epidermal neural crest stem cells could be a promising treatment for spinal cord injuries in dogs.

Collagen XVII is important for skin aging and wound healing.

The document concludes that stem cell inactivity is actively controlled and important for tissue repair and balance.

The research provides a gene-based framework for hair biology, highlighting the Hippo pathway's importance and suggesting links between hair disorders, cancer pathways, and the immune system.

Hair follicle samples effectively show how well the drug MK-0752 targets and engages with the Notch pathway.

TLR2 is important for hair growth and can be targeted to treat hair loss.

Formononetin, found in red clover, may treat hair loss with fewer side effects.

Tissue-derived extracellular vesicles are crucial for cancer diagnosis, prognosis, and treatment.

Hair aging is caused by stress, hormones, inflammation, and DNA damage affecting hair growth and color.

MSC-derived exosomes can help treat COVID-19, hair loss, skin aging, and arthritis.

Dexamethasone affects hair growth by altering levels of proteins that either promote or inhibit hair follicle growth.

Skin stem cells are crucial for maintaining and repairing skin, with potential for treating skin disorders and improving wound healing.

Hair follicles can be used to quickly assess drug effects in cancer treatment.

The right cells and signals can potentially lead to scarless wound healing, with a mix of natural and external wound healing controllers possibly being the best way to achieve this.

Fibroblasts are crucial for tissue repair and inflammation, and understanding them can help treat fibrotic diseases.