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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Different types of skin cells play specific roles in development, healing, and cancer.

Male pattern hair loss could hint at androgens affecting COVID-19 severity.

Macrophages help heal nerves by aiding the maturation of Schwann cells and are important for nerve repair.

Men's sensitivity to male hormones might affect how severe COVID-19 gets for them.

Hair, teeth, and mammary glands develop similarly at first but use different genes later.

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

Pregnancy can increase lupus activity, but careful planning and treatment can improve outcomes.

Mutant mice help researchers understand hair growth and related genetic factors.

Skin problems in COVID-19 patients are rare and may be due to the body's complex immune response or blood clotting issues.

Blocking the virus's entry into cells by targeting certain pathways could lead to early COVID-19 treatments.

Targeting the skin's endocannabinoid system could help treat skin disorders.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

Different types of fibroblasts play various roles in both healthy and diseased tissues, and understanding them better could improve treatments for fibrotic diseases.

Changes in skin microbes play a role in some skin diseases and could lead to new treatments.

Genetic mutations can cause hair growth disorders by affecting key genes and signaling pathways.

Skin and hair can regenerate after injury due to changes in gene activity, with potential links to how cancer spreads. Future research should focus on how new hair follicles form and the processes that trigger their creation.

Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.

The conclusion is that androgenetic alopecia and senescent alopecia have unique gene changes, suggesting different causes and potential treatments for these hair loss types.

New gene identification techniques have improved the understanding and classification of inherited hair disorders.

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

Blood tests can help understand the genetic differences in people with alopecia areata, including how severe it is and if it's inherited.

The study found stem cells in minor salivary glands that can differentiate and are involved in tumor formation when exposed to tobacco.

COVID-19 may harm male fertility and damage the reproductive system.

Canine epidermal neural crest stem cells could be a promising treatment for spinal cord injuries in dogs.

STAT3 signaling is important for healthy skin and hair follicles, and its disruption can lead to skin conditions like atopic dermatitis.

COVID-19 may worsen with androgens; anti-androgen drugs could help.

The document explains how to create detailed biological pathways using genomic data and tools, with examples of hair and breast development.

Hair loss doesn't affect COVID-19 severity.