research Oxidative Activity of the Type 2 Isozyme of 17β-Hydroxysteroid Dehydrogenase Predominates in Human Sebaceous Glands
The enzyme 17β-HSD type 2 mainly performs oxidation in human sebaceous glands, which may help protect against acne.
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research Treatment of Hirsutism and Acne with Cyproterone Acetate
Cyproterone acetate is effective for treating hirsutism and acne but less so for hair loss, with side effects similar to birth control pills.
research Clinical Relevance of Testosterone and Dihydrotestosterone Metabolism in Women
Testosterone and dihydrotestosterone play a role in women's health issues like excess hair and baldness, and treatments blocking these hormones may help.
research HSD3B1 Genotypes Conferring Adrenal-Restrictive and Adrenal-Permissive Phenotypes in Prostate Cancer and Beyond
Certain HSD3B1 gene types are linked to worse prostate cancer outcomes and affect treatment response and other health conditions.
research Novel Agents for the Treatment of Alopecia
New treatments for hair loss show promise, especially finasteride for men and a stronger minoxidil formula.
research How Effective Is Intralesional Injection of Triamcinolone Acetonide Compared with Topical Treatments in Inducing and Maintaining Hair Growth in Patients with Alopecia Areata? A Critically Appraised Topic
Intralesional triamcinolone acetonide can regrow hair in alopecia areata but often has temporary effects and side effects.
research Optimization of LC Method for the Determination of Testosterone and Epitestosterone in Urine Samples for Biomedical and Anti-Doping Research
Researchers developed a reliable method to measure testosterone and epitestosterone in urine for medical and anti-doping use.
research Curcumin Derivatives Inhibit Testicular 17β-Hydroxysteroid Dehydrogenase 3
Curcumin and its derivatives can block an enzyme important for making testosterone, with one derivative being particularly strong.
research Alpha-Spinasterol from Melandrium Firmum Attenuates Benign Prostatic Hyperplasia in a Rat Model
α-spinasterol from Melandrium firmum can help reduce prostate enlargement.
research Regional Difference in Sebum Production by Androgen Susceptibility in Human Facial Skin
The T-zone on the face has more androgen receptors and produces more oil than the U-zone.
research Is The Metabolism Of Testosterone To 5α-Dihydrotestosterone Required For Androgen Action In The Skin?
Testosterone conversion to 5α-DHT may not be essential for its effects on the skin.
research Hirsutism in Adolescent Females
The conclusion is that young women with excessive hair growth should be quickly tested for hormonal issues and treated to improve their social well-being.
research Androgens and Erythropoiesis: Induction of Erythropoietin-Hypersecretory State and Effect of Finasteride on Erythropoietin Secretion
Androgens increase EPO production, finasteride doesn't significantly impact it.
research The Role of Cytochrome P-450 in Dermatology
Cytochrome P-450 enzymes in the skin help break down various substances and could be targeted to treat skin conditions.
research Anti-Androgenic Therapy with Finasteride in Patients with Chronic Heart Failure – A Retrospective Propensity Score Based Analysis
Finasteride helps reduce heart enlargement in heart failure patients.
research Finasteride and the Uncertainties of Establishing Harms
Finasteride's potential harms are hard to accurately measure.
research Therapeutic Control of Androgen Action
Understanding how androgens work is key for creating new treatments for prostate issues and hair/skin conditions.
research Androgens and the Menopause
Testosterone replacement may help postmenopausal women with sexual function and bone density, but suitable treatments are limited.
research Role of Environmental Factors and Gonadotoxin Exposure in Unexplained Male Infertility
Environmental factors and exposure to toxins may contribute to male infertility by affecting sperm and hormone function.
research Treatment of Hyperandrogenism in Polycystic Ovary Syndrome
Hormonal therapies are effective for managing hair and skin symptoms in women with PCOS.
research Calcipotriene Plus Betamethasone Dipropionate Gel: A New Combination Therapy for Scalp Psoriasis
The new gel combining calcipotriene and betamethasone is effective and safe for treating scalp psoriasis.
research Chronic Erythematous Plaques Around The Ears
A man with painful ear plaques was diagnosed with discoid lupus and treated with medications and lifestyle changes.
research Comments Concerning the Real Risk of Sexual Adverse Events Secondary to the Use of 5-Alpha-Reductase Inhibitors
The document concludes that the risk of sexual side effects from 5-alpha-reductase inhibitors is low and often temporary, but more research is needed on potential permanent effects.
research Spironolactone
Spironolactone can cause side effects like high potassium levels and breast enlargement, and patients need careful monitoring.
research Dermatological Drugs and Cosmetics: Allergenic and Adverse Effects
Some cosmetics and dermatological drugs can cause allergic reactions and side effects, like skin irritation and systemic issues.
research Treatment of Hair Loss
Finasteride and minoxidil are effective for hair loss, but continued research is needed for better treatments.
research Treatment of Invasive Aspergillosis with Itraconazole
Itraconazole is potentially effective for treating invasive aspergillosis, but more research is needed.
research Molecular Mechanisms of Androgenetic Alopecia
AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.
research The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases
The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.
research The Clinical Development of a 5α-Reductase Inhibitor, Finasteride
Finasteride effectively treats BPH, but needs more trials to understand potential.