1 citations
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April 2024 in “Metabolites” In this study, researchers found that male and female APCHi mice exposed to ionizing radiation showed near-normal lipid and metabolite levels, suggesting activated protein C may offer some protective effects against radiation-induced damage affecting organ systems.
This survey study reported the pricing, formulation, and delivery options for compounded topical alopecia medications in the tri-state area, finding varied costs and noting the capability of most pharmacies to exceed commercially available minoxidil concentrations and offer delivery services.
This study identified ISX9 as a novel agonist of the Wnt/β‐catenin pathway, which promoted hair regrowth in mice and may offer a therapeutic approach for alopecia.
April 2010 in “Cancer Research” This study suggests that Mcl-1 has a non-apoptotic role in promoting keratinocyte proliferation and Wnt/β-catenin signaling, potentially indicating a novel oncogenic activity.
March 2024 in “Preprints.org” In a study conducted on mice, researchers observed that exposure to ionizing radiation led to significant metabolic imbalances, including dyslipidemia and disruptions in amino acid metabolism, with activated protein C providing partial protection by normalizing certain plasma metabolites and lipids.
October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that neonatal Regulatory T cells are crucial for maintaining PPARγ signaling in hair follicles, which supports melanocyte stem cell function and skin pigmentation during early postnatal development.
June 2022 in “Biotechnological Research” This review discusses the potential of activated autologous platelet-rich plasma (aaPRP) for improving diabetic foot ulcer outcomes but reports no new clinical results, noting the need for further evidence.
November 2015 in “European Journal of Inflammation” This review discusses the potential pathogenic mechanisms of cicatricial alopecia and emphasizes the need for further research on treatment methods, but it reports no new clinical findings.
23 citations
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January 2020 in “Frontiers in Pharmacology” In this study, DHT was observed to have varying effects on hair follicle growth and related protein expression depending on concentration, with the Wnt/β-catenin pathway potentially playing a significant role.
6 citations
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March 2022 in “Molecules” This study found that methyl jasmonate can induce tanshinone biosynthesis in S. miltiorrhiza by affecting the expression of the SmMEC gene, as supported by RT-PCR and transcriptomic data.
1 citations
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January 2013 in “Journal of S C C J” This study suggests that scalp massage may reduce stress, as indicated by decreased salivary cortisol and increased secretory immunoglobulin A, and improve comfort by reducing physical fatigue and negative emotions.
September 2023 in “Plant journal” This study showed that the zinc finger protein GIS3 is important for root hair growth in Arabidopsis by regulating RHD2 and RHD4 genes, with application of ethylene and cytokinin helping restore root hair presence in mutated variants.
September 2025 in “Australasian Journal of Dermatology” In this update, researchers incorporated TGA-approved Janus Kinase inhibitors into the Australian treatment guidelines for chronic, moderate to severe Alopecia areata, aiming to enhance recommended therapies by providing guidance on the use and management of these systemic medications.
May 2015 in “HAL (Le Centre pour la Communication Scientifique Directe)” In this study, the stability properties of various active pharmaceutical ingredients (APIs) were characterized, revealing how factors like pressure and water sensitivity influence their intrinsic stability and potential degradation.
50 citations
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November 2021 in “Viruses” This study observed that in vitro exposure to dihydrotestosterone worsened COVID-19 spike protein-induced endothelial injury, while spironolactone showed potential in reducing this effect, suggesting a rationale for further evaluation in treating COVID-19.
50 citations
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April 2021 in “Frontiers in Immunology” This review discusses neuroimmune communication in skin disorders and peripheral neuropathic pain, highlighting the complex interactions between sensory neurons and immune cells; it reports no new clinical results but suggests potential future therapies.
38 citations
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April 2017 in “PLOS Genetics” This study found that human progenitor keratinocytes form unique complements of enhancers and super-enhancers during differentiation and migration, influencing gene expression and skin disease variant enrichment.
18 citations
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July 2022 in “Frontiers in Immunology” This review discusses the potential impact of volatile organic compound exposure on the onset and progression of autoimmune diseases and reports no new experimental findings.
11 citations
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February 2023 in “British Journal of Pharmacology” This study found that ISX9 may activate the Wnt/β-catenin signaling pathway and holds potential as a therapeutic agent for treating alopecia.
3 citations
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February 2015 in “Mechanisms of development” This study observed that areola formation in mice requires exposure to pregnancy hormones and mechanical strain, beyond individual stimuli like hormonal milieu or strain alone.
1 citations
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September 2025 in “Frontiers in Immunology” This study found that FRβ knockout mice exhibited autoimmune symptoms and slower tumor growth compared to wild type mice, suggesting that the FRβ receptor may play a role in regulating immune responses in tumors and autoimmune conditions.
1 citations
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February 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that a specific fragment of AIMP1 secreted by hair follicle stem cells can stimulate dermal papilla cells and promote hair regrowth.
1 citations
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January 2021 in “European journal of medical and health sciences” This review proposes a treatment protocol for androgenetic alopecia using platelet-rich plasma, but reports no new clinical results, highlighting the need for standardized preparation and assessment methods.
May 2025 in “Journal of the Egyptian Womenʼs Dermatologic Society” This study found that immune privilege is preserved in hair follicles of nonsegmental vitiligo patients compared to those with alopecia areata, potentially protecting follicular melanocytes from autoimmune attacks.
This study found that Smad4 is crucial for satellite cell amplification during skeletal muscle regeneration, with aged cells exhibiting less Smad4 and reduced regenerative capability in mice.
November 2023 in “Cureus” In this pilot study, a 12-week topical treatment with a lotion containing magnetized saline water significantly increased hair count and hair mass index while activating autophagy in the scalp of 20 Caucasian men with mild-to-moderate androgenetic alopecia.
5 citations
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June 2024 in “Developmental Cell” In this study, activating TRPV1 nociceptors in mice skin stimulated dormant hair follicles and promoted hair growth through a mechanism involving dermal macrophages, fibroblasts, and neuropeptides, highlighting a new role for nociceptors in tissue recovery after injury.
February 2025 in “Biomolecules” This research found that melatonin has a bidirectional effect on hair follicle stem cell survival, improving it at low doses and inhibiting it at high doses.
20 citations
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January 2022 in “Polymers” In this review, researchers reported that incorporating nanoparticles into natural-based biomaterials enhanced scaffolding properties, cellular interactions, and outcomes in wound healing, with promising implications for tissue engineering and regenerative medicine, although many signaling pathways involved are still not fully understood.
11 citations
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March 2015 in “Life sciences” This study found that using conditioned medium from vitamin D3 pre-activated preadipocytes enhanced hair regeneration in mice by promoting angiogenesis.