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The TRPV3 channel structure changes linked to severe itch and hyperkeratosis were identified using cryo-EM.

Overactivating Hedgehog signaling makes hair follicle cells in mice grow hair faster and create more follicles.

Hair growth is influenced by various body and external factors, and neighboring hairs communicate to synchronize regeneration.

Human stem cells can help form hair follicles in mice.

β-catenin is essential for stem cell activation and proliferation in hair follicles.

Polycomb Repressive Complex 2 is not needed for hair regeneration.

Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.

The calcineurin/NFAT pathway plays a significant role in the development and growth of a type of skin cancer called cutaneous squamous cell carcinoma.

Vav2 and Vav3 proteins help control skin stem cell numbers and activity in both healthy and cancerous cells.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Different types of fibroblasts play various roles in both healthy and diseased tissues, and understanding them better could improve treatments for fibrotic diseases.

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

Low oxygen areas help maintain and protect blood stem cells by using a simple sugar breakdown process for energy and managing their activity levels.

Enzymes called PADIs play a key role in hair growth and loss.

TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.

Deregulation of stem cell function is central to the development of some cancers.

Blocking DPP4 can potentially speed up hair growth and regeneration, especially after injury or in cases of hair loss.

Certain cancer drugs interact with skin bacteria to cause acne-like rashes.

Allium hookeri extract may help promote hair growth and protect cells from damage.

Wnt/beta-catenin signaling in the skin helps fat cell development during hair growth and repair.

Blocking JAK/STAT pathways can help treat hair loss from alopecia areata.

Skin's epithelial stem cells are crucial for repair and maintenance, and understanding them could improve treatments for skin problems.

Good feather growth in poultry needs the right balance of proteins, amino acids, minerals, and vitamins.

Skin stem cells remember past inflammation, helping them respond better to future injuries and possibly aiding in treating skin issues.

Vav2 changes how hair follicle stem cells' genes work as they age, which might improve regeneration but also raise cancer risk.

Eph/ephrin signaling is important for skin cell behavior and could be targeted to treat skin diseases.

Different types of skin cells are organized in a special way in large wounds to help with healing and hair growth.

Cholesterol-related compounds can stop hair growth and cause inflammation in a type of scarring hair loss.

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

Stem cell niches support, regulate, and coordinate stem cell functions.