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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.

Wnt signaling is crucial for skin and hair development and its disruption can cause skin tumors.

Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Flightless I protein affects hair growth, with low levels delaying it and high levels increasing hair length in rodents.

Mutations in Plcd1 and Plcd3 together cause severe hair loss in mice.

Some vitamin D analogs can thicken skin and reduce pore size like a common acne treatment, with one analog also affecting skin growth factors.

Improving artificial vascular grafts requires better materials and surface designs to reduce blood clotting and support blood vessel cell growth.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Increasing mir-302 turns human hair cells into stem cells by changing gene regulation and demethylation.

Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Formyl-peptide receptor agonists could be new anti-inflammatory drugs.

The three estrogen receptor genes are highly expressed in zebrafish neuromasts during development.

The protein folliculin, involved in a rare disease, works with another protein to control how cells stick together and their organization, and changes in this interaction can lead to disease symptoms.

The nude gene causes skin cell overgrowth and improper development, leading to hair and urinary issues.

The extracellular matrix is crucial for controlling skin stem cell behavior and health.

Two-photon microscopy helps observe hair follicle stem cell behaviors in mice.

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.

Glutamine metabolism affects hair stem cell maintenance and their ability to change back to stem cells.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

Eph/ephrin signaling is important for skin cell behavior and could be targeted to treat skin diseases.

Distinct β-catenin patterns are linked to cell growth, not cell death, in lung cancer.

Heparan sulfate is important for hair growth, preventing new hair formation in mature skin, and controlling oil gland development.

Beard and scalp hair cells have different gene expressions, which may affect beard growth characteristics.

Stress activates a special function of the Vitamin D receptor with the help of c-Jun, which can also prevent cell death.

The document concludes that careful design of genetic fate mapping experiments is crucial for accurate cell lineage tracing in mice.

The study concluded that specific proteins are necessary to maintain the structure that holds epithelial cells tightly together.