March 2025 in “Frontiers in Pharmacology” This study developed a hydrogel dressing incorporating angelica polysaccharides, demonstrating enhanced wound healing properties in a mouse model by promoting rapid hemostasis, tissue healing, and new blood vessel formation compared to Tegaderm™ film.
February 2025 in “Journal of Nutrients” This research reviews the scientific literature on bone broth extract, exploring its nutritional composition, potential health benefits, food industry applications, and risks such as heavy metal and antibiotic contamination. Results are not reported in this summary.
December 2024 in “Deleted Journal” This review explores the challenges of treating chronic wounds and highlights regenerative medicine as a promising approach, emphasizing the roles of growth factors, stem cell therapies, and novel regenerative treatments in improving wound healing and tissue regeneration.
November 2024 in “Communities in ADDI (University of the Basque Country)” Antisense oligonucleotides show promise for treating Myotonic Dystrophy type I.
November 2024 in “Journal of Scientific Agriculture” This paper reviews the benefits of using silk proteins as natural ingredients in cosmetics, highlighting their potential for improving skin and hair health due to properties like antimicrobial activity, UV resistance, and enhanced moisture absorption.
October 2024 in “International Journal of Pharmaceutical Sciences Review and Research” This study reviewed existing literature on Androgenetic Alopecia treatments, finding that minoxidil promotes hair growth but can cause side effects due to its traditional formulations. Novel delivery systems like film-forming sprays may reduce these side effects and enhance efficacy.
This study found that culturing fibroblasts on stiffer substrates mimicking fibrotic wounds led to an aligned EDA fibronectin matrix with thinner fibers and decreased YAP activity, suggesting disrupted signaling that might be restored to promote regenerative wound repair.
July 2024 in “ADMET & DMPK” This review discusses the potential for surface-modified nanostructured lipid carriers to enhance hair regrowth by improving drug absorption and stability, focusing on their use with agents like minoxidil and finasteride for hair loss treatment.
This article highlights the gap between medically necessary dermatologic gender-affirming procedures and insurance coverage for transgender and gender diverse service members in the US Military, and discusses how dermatologists can support gender-affirming care and address existing healthcare disparities.
March 2024 in “Drug development & registration” This review highlights the potential of mesenchymal stem cell secretome for developing topical treatments aimed at skin regeneration and treating various diseases, but notes a lack of studies on safety, efficacy, and standardization processes for its clinical use.
March 2024 in “International Journal of Drug Delivery Technology” This study reviews the potential of electrospun nanofiber mats as innovative drug delivery systems for wound healing, emphasizing their ability to enhance drug release, improve cell adhesion, and promote tissue regeneration by incorporating antibiotics, growth hormones, or stem cells.
November 2023 in “Linköping University medical dissertations” This research presents a comprehensive workflow for producing EMA-compliant autologous keratinocyte-based therapies for wound healing and explores miRNA-mediated regulations in human keratinocytes and adipose-derived mesenchymal stem cells.
August 2023 in “International journal of experimental research and review” This study found that in models of diabetic wound healing, extracts from the flavonoid and tannin fractions of Ficus racemosa leaves improved wound closure time, increased breaking strength of incision wounds, and exhibited hypoglycemic activity.
This review discusses the potential of extracellular vesicles from various sources for skin rejuvenation and cosmetic use, noting promising results, especially with mesenchymal stem cell-derived vesicles, but reports no new clinical results.
This article reviews various topics including medically important plants in dermatology, supporting medicinal herbs for primary dysmenorrhea, and several drug delivery systems, without providing new clinical findings.
January 2023 in “Marmara University Open Access System” This study found that tideglusib delivered topically in a bacterial cellulose hydrogel showed positive effects on the wound healing of rat palatal mucosa, as observed through macroscopic, histomorphometric, and immunohistochemical evaluations.
82 citations
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August 2017 in “Cell Reports” This study found that antibiotic-induced gut dysbiosis, particularly overgrowth of Lactobacillus murinus, can lead to hair loss in mice by depleting biotin.
39 citations
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March 2018 in “Archives of Dermatological Research” This review describes the molecular interactions between androgens and Wnt/ß-catenin signaling in androgenetic alopecia but reports no new experimental or clinical findings; the authors discuss potential Wnt/ß-catenin-targeted treatments for hair growth.
14 citations
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May 2019 in “Experimental Dermatology” In this study, adipose tissue secretome was shown to enhance oxidative stress resistance and promote cell proliferation in vitiligo cells, suggesting a potential natural treatment approach.
5 citations
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January 2013 in “Cells Tissues Organs” This study found that activin B promotes the initiation and development of hair follicles in both cultured and neonatal mouse skin models.
2 citations
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October 2020 in “Journal of Pharmacology and Experimental Therapeutics” This study found that in a mouse model of bronchopulmonary dysplasia, minoxidil administered at 50 mg/kg/day did not impact lung development or inhibit lysyl hydroxylation.
February 2010 in “ePrints Soton (University of Southampton)” This research found that androgen bioactivity plays a role in normal female sexual differentiation, suggesting females develop within a significant androgenic environment, with implications for understanding conditions like congenital adrenal hyperplasia.
April 2018 in “Journal of Investigative Dermatology” This study observed that β-catenin overexpression in human squamous cell carcinoma cells led to increased CREB expression, which significantly enhanced clonogenic activity, suggesting CREB as a β-catenin-regulated factor promoting cancer characteristics.
January 2024 in “Wiadomości Lekarskie” This study reports that Abelson Interactor 1 (ABI1) regulates androgen receptor transcription in prostate cancer, identifying it as a potential target for new therapies addressing treatment resistance.
72 citations
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January 2003 in “American Journal of Pathology” This study found that the co-activator CBP enhances the agonistic action of hydroxyflutamide on androgen receptors, suggesting a mechanism for therapy resistance in prostate cancer.
August 1994 in “Molecular Endocrinology” This study found that AtT-20 pituitary cells with higher cAMP-dependent kinase activity had larger calcium currents and significantly increased beta-endorphin release compared to cells with lower kinase activity.
January 2024 in “Wiadomości Lekarskie” In this study, researchers developed a novel computational framework using deep reinforcement learning to identify strategies for cellular reprogramming in gene regulatory networks, showing its effectiveness in a model of immune response against infection.
May 2010 in “Europe PMC (PubMed Central)” This chapter discusses the synthesis and analysis of near-infrared fluorescent activity-based probes for imaging cysteine protease activity, reporting potential benefits for disease diagnosis but noting challenges in imaging specific locations with high cathepsin activity.
65 citations
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February 2011 in “Molecular cancer therapeutics” This study reported that the novel AKT inhibitor CCT128930 demonstrated significant antitumor activity in human cancer cell lines and xenografts, highlighting its potential as an anticancer therapy.
13 citations
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January 2011 in “International Journal of Trichology” CTA is often mistaken for AA but doesn't respond to steroids and may require hair transplantation.