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This study used single-cell transcriptomic analysis to identify a specific cell population in acne patients' non-lesional skin, providing evidence for the comedone switch hypothesis by suggesting a shift towards infundibular differentiation at the expense of sebaceous gland maintenance.

This study found a significant correlation between lower triglyceride levels and reduced acne severity among medical students, while no significant association was observed between BMI and acne severity.

This study observed that a significant proportion of women with acne vulgaris also met the criteria for PCOS, suggesting a notable link between the two conditions.

This study highlights that acne is a common issue for transgender men undergoing testosterone therapy, with management generally following similar guidelines as for cisgender individuals.

This narrative review found that combined oral contraceptives remain the primary treatment for hirsutism and acne in women with PCOS, but highlighted the need for further research to refine therapeutic options given the variable efficacy and emerging treatments like GLP-1 receptor agonists.

In this case study, a woman with alopecia areata experienced significant hair regrowth after starting ritlecitinib but developed an acneiform eruption, leading to the discontinuation of the drug and subsequent hair loss relapse; the eruption suggests a treatment-limiting adverse effect of JAK inhibitors.

This study found that patients with severe acne vulgaris had different systemic inflammatory indices and hematologic parameters compared to healthy individuals.

In this case study, the authors reported a post-bariatric surgery patient who developed acne due to inappropriate vitamin supplementation, emphasizing the need for careful monitoring and education on vitamin use to prevent complications in such patients.

This study found that female patients with acne had significantly higher insulin resistance compared to a control group without acne, suggesting that acne could serve as an early clinical marker of insulin resistance in women of reproductive age.

This case report describes the improvement of papulo-pustular acne in a 27-year-old woman through individualized homoeopathic treatment with Kalium bromatum, placebo, and lifestyle advice, highlighting its potential usefulness in acne management.

This narrative review reports preliminary evidence suggesting that an integrative homeopathic approach, combining constitutional treatment with topical mother tinctures, may aid in healing and reducing inflammatory acne lesions, though larger trials are needed to confirm these effects.

This review synthesizes current research on how the interaction between the skin microbiome and exosome-mediated communication influences hair disorders, and discusses how microbiome restoration and exosome-based therapies could advance treatments for conditions like alopecia by promoting hair regrowth and follicular health.

This study found that combining shikimic acid with Prunus mume fruit extract significantly reduces type I 5α-reductase levels in testosterone-stressed skin sebocytes, surpassing the effects of shikimic acid or standard acne treatments alone, and shows promise for stable, non-irritating acne remedies in cosmetic formulations.

In this cross-sectional study, researchers observed that acne vulgaris is highly prevalent among adults and found that inadequate sleep is significantly associated with more severe acne, while diet and stress showed no significant link. Additionally, acne negatively impacts psychosocial well-being, affecting individuals' social interactions.

This study reviewed isotretinoin's effectiveness in treating moderate to severe acne and discussed the need to balance its robust treatment benefits with careful monitoring due to significant physiological and psychological side effects.

This review discusses the link between PCOS and acne, highlighting the roles of hyperandrogenism and insulin resistance, but it reports no new clinical findings.

This review of studies published after 2020 found that probiotics may significantly reduce acne lesions and improve skin health in individuals with acne vulgaris, though further high-quality research is needed for confirmation and treatment optimization.

This review highlights the role of sex hormones in skin health, observing that hormonal changes throughout a woman's life can affect skin conditions such as acne and hair loss, with treatments involving hormonal therapies and the importance of a multidisciplinary approach.

This source reviews the influence of sex hormones on skin health, detailing how hormonal fluctuations impact dermatological conditions throughout a woman's life and highlighting the necessity for integrated dermatological, gynecological, and endocrine care alongside mental health support to address these conditions' physical and psychological effects.

This review describes how sex hormones like estrogens and androgens influence skin health, linking hormonal fluctuations to conditions such as acne and hair loss, and underscores the importance of a multidisciplinary approach to treatment that includes mental health support.

This study examines the genetic underpinnings of chronic dermatological conditions like acne, androgenetic alopecia, and alopecia areata, concluding that a deep understanding of these mechanisms can advance patient-specific treatments and inform cosmetic practices related to skin and hair health.

This source highlights the potential benefits of identifying risk factors and intervening early to mitigate acne scarring and improve quality of life. It also emphasizes the importance of recognizing acne severity predictors to guide preventive strategies and optimize patient outcomes.

This review discusses the effectiveness and mechanisms of combined oral contraceptives in treating acne vulgaris but reports no new clinical results; the authors highlight their antiandrogenic effects for managing acne and related endocrine disorders.

This review provides current insights into the role of Demodex mites in acne and rosacea, detailing their involvement in sebaceous gland diseases due to their potential to cause inflammation and disrupt skin microbial balance, while suggesting methods to correct mite overgrowth.

In this study, isotretinoin, an effective treatment for severe acne, was found to significantly impact hematological, inflammatory, and oxidative stress biomarkers, suggesting potential risks alongside its therapeutic benefits.

This article reviews the management of polycystic ovarian syndrome, highlighting lifestyle modification and individualized pharmacological treatment strategies, and reports no new clinical results.

This study found that the protein C4BPA may link insulin resistance and acne vulgaris by influencing lipid metabolism and inflammatory pathways, suggesting it as a potential mediator in the pathogenesis of both conditions.

Ovarian hyperthecosis caused high testosterone and virilization symptoms in a 60-year-old woman, which improved after surgery.

This review examines the genetics of acne vulgaris, concluding that stem/progenitor cell maintenance and cellular migration are key processes in its pathogenesis, potentially shifting future treatment strategies beyond traditional antibiotics and retinoids, which have notable side effects.

Acne involves increased lipid production and inflammation, affecting skin cell behavior and treatment resistance.