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RPGRIP1L helps skin cells stick together by blocking PKCβII, which can prevent skin blistering like in pemphigus.

The document highlights various patents for new compounds with potential treatments for multiple diseases, including cancer, hormonal disorders, and diabetes.

Cyclosporin A and FK506 can start new hair growth in mice, but ascomycin and rapamycin cannot.

Air pollution worsens skin diseases and aging by causing inflammation and oxidative stress.

Turmeric may have benefits for skin health, but more research is needed to confirm its effectiveness.

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

Lithium therapy may cause skin problems like hidradenitis suppurativa and other side effects, which can improve after stopping the medication.

Oral retinoids can cause side effects ranging from mild to severe, including birth defects, and require careful monitoring and contraception.

Thujae occidentalis semen extract may help treat male pattern baldness by blocking a hair loss-related enzyme and reducing hair loss in mice.

Germacrone from Curcuma aeruginosa may help treat conditions related to male hormones by blocking a specific enzyme.

Subcutaneous contraceptives can cause side effects like menstrual changes, headaches, weight gain, and pain at the implant site.

Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.

FCE 28260 is a stronger and longer-lasting inhibitor of 5α-reductase than finasteride, which may make it a better treatment for certain medical conditions.

Changing the C-ring structure in certain compounds can make them better at blocking a specific human enzyme.

Saw palmetto extract can block the enzyme that converts testosterone in pig prostate cells.

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

Some herbal treatments are effective for skin disorders, but more research and regulation are needed.

LED light therapy is effective for skin and hair treatments but requires careful use to minimize risks.

Chronic inflammatory skin diseases are caused by disrupted interactions between skin cells and immune cells.

Clascoterone is safe for the heart, even at high doses.

4-(4-Phenoxybenzoyl)benzoic acid derivatives can both increase and decrease certain types of reactive oxygen species, and may be relevant to hair loss.

Old drugs like finasteride and spironolactone are being successfully used for hair loss and skin conditions, and many other drugs show promise for new uses in dermatology.

Carbamates may help treat androgen-dependent conditions by changing how certain lipid enzymes are produced.

Researchers found certain genes are overactive and others are underactive in men with early balding, which could help create new treatments.

Understanding drug interactions, side effects, and patient-specific factors is crucial for effective dermatological care.

Different substances affect hair and skin cell growth in various ways.

Different substances affect hair and skin cell growth in various ways, with some promoting and others inhibiting cell proliferation.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.