38 citations
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November 2012 in “Expert Opinion on Drug Safety” This article reviews different acne treatments and emphasizes the importance of being aware of their potential side effects, but reports no new clinical results.
April 2026 in “Biomedical Research and Therapy” This study found that certain genetic variants, specifically CYB5R1 and IL1A, may be linked to different types of acne scarring, with CYB5R1 associated with atrophic scarring and IL1A with fibrotic scarring, indicating a potential polygenic nature of acne scarring.
24 citations
,
November 2016 in “Molecular Medicine Reports” This study found that women with acne resistant to conventional treatments had significantly higher levels of testosterone, DHEA‑S, prolactin, and LH, suggesting potential underlying hormonal disorders.
15 citations
,
January 2016 in “Dermatologic Clinics” This article offers strategies for managing acne effectively and safely, emphasizing treatment optimization, patient tailoring, and addressing antimicrobial resistance, but reports no new clinical results.
This study found that women with postadolescent acne often exhibit symptoms of hyperandrogenism, such as hirsutism and androgenetic alopecia, but have minimal hormone profile abnormalities.
43 citations
,
November 2018 in “Nature Communications” This genome-wide association study identified 20 genetic signals at 15 risk loci related to severe acne, revealing new insights into its genetic predisposition, particularly affecting skin structure and maintenance.
74 citations
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October 2015 in “Experimental Dermatology” This study found that mTOR gene expression was significantly increased and S6K1 activation was observed in skin samples from acne patients compared to healthy controls, suggesting mTORC1's involvement in acne pathogenesis.
July 2025 in “Canadian Family Physician” This source summarizes the new 2024 American Academy of Dermatology guidelines, emphasizing strong recommendations for topical and oral therapies like benzoyl peroxide, doxycycline, and isotretinoin in managing acne vulgaris, while outlining the importance of tailored treatments for diverse patient needs in Canadian practice.
April 2023 in “Journal of Investigative Dermatology” In this study, Nd:YAG picosecond lasers using fractional micro-lens array were found to have a comparable effect to ablative fractional Er:YAG lasers in treating atrophic acne scars, with better safety profiles but slightly less patient satisfaction.
This study found that the prevalence of polycystic ovarian morphology is high among women aged 21-45 with acne and/or androgenic alopecia, especially in those with combined dermatological symptoms.
40 citations
,
September 2012 in “European Journal of Dermatology” This study found that long pulsed Nd-YAG laser treatment significantly improved acne keloidalis nuchae by reducing inflammation and hair follicles, with early intervention yielding the best results.
110 citations
,
October 2013 in “The Journal of Sexual Medicine” This study found that testosterone therapy in trans men increased facial and body hair growth while the prevalence and severity of acne peaked at 6 months but were primarily mild after long-term treatment.
25 citations
,
February 2024 in “Pharmaceutics” This article outlines how nanotechnology strategies, including phospholipid-based nanocarriers like liposomes, could enhance the effectiveness and skin tolerability of acne treatments, aiming to reduce side effects and improve patient compliance in managing acne vulgaris.
11 citations
,
November 2022 in “Journal of Endocrinological Investigation” In this study, gender-affirming hormonal treatment was associated with increased hair growth, acne, and alopecia prevalence in transgender individuals assigned female at birth, while opposite dermatological changes were observed in those assigned male at birth.
3 citations
,
February 2025 in “Journal of Cosmetic Dermatology” This study supports the idea that increased intestinal permeability may play a role in causing acne vulgaris and confirms a relationship between diet and acne. Further research is needed to understand how specific foods influence acne through this mechanism.
2 citations
,
September 2016 in “Journal of skin and stem cell” This study observed that acne was strongly associated with higher BMI, alopecia, menstrual dysfunction, positive familial history, and overuse of sweet and fatty foods among dermatology patients.
1 citations
,
October 2010 in “Cambridge University Press eBooks” This article reviews the diagnosis of hyperandrogenism in PCOS, discussing its clinical and biochemical components, but reports no new clinical results.
This study observed that acne and hirsutism were common among women with PCOS, and found a significant link between higher BMI and the presence of acanthosis nigricans and hirsutism.
January 2023 in “Mansoura Medical Journal” This study suggests that increased levels of ischemia-modified albumin, indicating oxidative stress, are associated with greater severity of acne vulgaris.
February 2020 in “International Journal of Medical and Biomedical Studies” This study found that adult acne predominantly affects females, with persistent acne being common, and noted a low prevalence of PCOS among female adult acne patients.
January 2008 in “Padua Research Archive (University of Padua)” This study observed that hereditary factors were associated with acne duration but not severity, and found a potential role of CYP450 1A1 polymorphisms in acne pathogenesis.
June 2021 in “Egyptian Journal of Dermatology and Venereology” This study found that psoriasis, acne, and androgenetic alopecia are associated with an atherogenic lipid profile, suggesting an increased risk of atherosclerosis and cardiovascular disease, especially among psoriasis patients.
December 2020 in “Journal of Skin and Sexually Transmitted Diseases” This study found no significant correlation between serum testosterone or DHEAS levels and the severity of acne or FPHL in a localized female population, but noted most patients had low testosterone levels.
1265 citations
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October 2013 in “The Journal of Clinical Endocrinology and Metabolism” This guideline from the Endocrine Society recommends using the Rotterdam criteria for diagnosing polycystic ovary syndrome and outlines first-line treatments, emphasizing hormonal contraceptives and lifestyle intervention.
49 citations
,
August 2007 in “Dermatologic surgery” This review discusses newer therapeutic techniques for treating postacne scarring, highlighting their effectiveness for particular grades of scars, and reports no new clinical results.
43 citations
,
May 1988 in “British Journal of Dermatology” This study reported that patients with acanthosis nigricans and insulin resistance exhibited higher insulin levels and were associated with increased insulin resistance correlating with serum testosterone levels.
15 citations
,
February 2017 in “Nursing Clinics of North America” This article reviews common skin reactions associated with epidermal growth factor receptor inhibitors and reports no new clinical findings, emphasizing the need for understanding nursing care and oncodermatology.
8 citations
,
October 2023 in “JMIR dermatology” ChatGPT can be a helpful dermatology resource but should not replace professional consultations.
June 2024 in “IP Indian journal of clinical and experimental dermatology” This study reports that platelet-rich plasma therapy significantly improved hair regrowth in alopecia areata and reduced the severity of atrophic acne scars over six months, with generally mild side effects.
June 2018 in “Journal of evolution of medical and dental sciences” In this study, polycystic ovarian disease was identified as a prevalent chronic endocrinopathy among women of reproductive age, with common dermatological symptoms such as hirsutism, acne, and androgenic alopecia.