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Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.

This study found that acne lesion formation involves early hyperkeratinization and inflammation around hair follicles, creating a self-sustaining cycle that may progressively worsen acne.

This study reviewed the physiological and psychological impacts of acne vulgaris, highlighting its complex interactions with endocrine issues, sebum production, and immune response, while suggesting that a multidisciplinary approach can inform future treatments and improve quality of life for those affected.

This review discusses the relationship between acne, body hair, and androgenic stimulation in adolescent girls, emphasizing treatment decisions based on disease severity rather than endocrine findings.

This study suggests that the gene rs27647 polymorphism may play a role in the pathogenesis of severe acne vulgaris in post-adolescent male patients.

In a double-blind clinical trial, this study found that a gel containing chitosan-coated spironolactone nanoparticles effectively reduced acne lesions over 8 weeks without adverse skin effects, suggesting potential for enhanced acne treatment through targeted skin delivery.

This study found that serum irisin levels were significantly lower in patients with acne vulgaris compared to healthy controls and were negatively correlated with insulin resistance and disease severity.

This study found that the count of CAG trinucleotide repeats in the androgen receptor gene may be associated with acne in female patients without hyperandrogenism.

This study found that 32.5% of reproductive-age women in Sichuan, China, had acne, with significant associations between acne and conditions such as PCOS and hyperandrogenism.

This review discusses various treatments for adult acne in women, including topical, systemic, and alternative therapies, and reports no new clinical results.

This report shares the authors' experience using spironolactone for treating acne in a PCOS clinic, but provides no new clinical results.

This study suggests that SRD5A2 polymorphisms may increase the risk of acne in individuals with normal serum testosterone levels, particularly in the Chinese population.

In this study, 65% TCA showed better improvement for acne scars compared to 50% GA, but GA may be a safer alternative with fewer adverse effects.

This narrative review reports preliminary evidence suggesting that an integrative homeopathic approach, combining constitutional treatment with topical mother tinctures, may aid in healing and reducing inflammatory acne lesions, though larger trials are needed to confirm these effects.

This review of studies published after 2020 found that probiotics may significantly reduce acne lesions and improve skin health in individuals with acne vulgaris, though further high-quality research is needed for confirmation and treatment optimization.

In this randomized clinical trial, the authors reported that after 12 weeks, 5% dapsone gel was more effective than 1% clindamycin phosphate gel in treating mild to moderate acne vulgaris, showing efficacy in 78.2% of patients compared to 52.7% with clindamycin.

This study suggests that improving public awareness and educational initiatives about polycystic ovary syndrome could lead to earlier diagnoses and treatments, enhancing women's quality of life while reducing healthcare costs.

This study reports that an intervention decreased glucose and insulin levels, indicating improved insulin resistance, which is linked to a skin condition called acne vulgaris and other disorders associated with insulin resistance.

This study investigates whether adding 30% supramolecular salicylic acid to conventional treatment for mild to moderate acne vulgaris is safe and effective, though specific results are not reported in the abstract.

This trial explores whether spironolactone is more effective than cyclines for treating moderate acne in adult women, providing a potential alternative amidst concerns over antibiotic resistance.

This introduction highlights the impact of acne vulgaris on quality of life and the complexity of selecting effective treatments, but it presents no new clinical results.

This article provides an overview of acne vulgaris, discussing its causes, presentation, and psychosocial impact, but it reports no new research findings or clinical results.

This study suggests the mechanical effect of injecting a solution is more important than the solution's nature in treating atrophic acne scars, with UBM sonography proposed for objective assessment.

This abstract does not provide study results but outlines that acne is influenced by factors like androgens, sebum production, abnormal keratinization, and inflammatory reactions involving lymphocytes, macrophages, and neutrophils.

This review evaluated current evidence on minoxidil's potential to treat scars and reported reduced collagen accumulation and fibrosis in various studies, suggesting its antifibrotic effects may benefit wound healing; however, direct studies on acne scars are yet to be conducted.

This study found that a combination therapy of subcision, micro-needling, and TCA CROSS led to significant improvement in atrophic acne scars, with many patients showing improved scar grades over the treatment period.

Many women with hard-to-treat acne also have PCOS.

This review explores how androgens and growth hormone influence the development of terminal hairs and sebaceous glands, attributing variability in hirsutism and acne to differing genetic sensitivities to androgens, but reports no new experimental data.

This review reports that 100 mg/day spironolactone improved hair growth more than placebo and was more effective in reducing hair growth than finasteride and low-dose cyproterone acetate, but its effectiveness for acne remains unclear due to small sample sizes.

This study found that in adults over 25, stress from lifestyle changes, sensitive skin, stopping oral contraceptives, and the use of full-coverage foundations were associated with increased severity of acne.