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This study found that combining shikimic acid with Prunus mume fruit extract significantly reduces type I 5α-reductase levels in testosterone-stressed skin sebocytes, surpassing the effects of shikimic acid or standard acne treatments alone, and shows promise for stable, non-irritating acne remedies in cosmetic formulations.

In this cross-sectional study, researchers observed that acne vulgaris is highly prevalent among adults and found that inadequate sleep is significantly associated with more severe acne, while diet and stress showed no significant link. Additionally, acne negatively impacts psychosocial well-being, affecting individuals' social interactions.

This study reviewed isotretinoin's effectiveness in treating moderate to severe acne and discussed the need to balance its robust treatment benefits with careful monitoring due to significant physiological and psychological side effects.

This review discusses the link between PCOS and acne, highlighting the roles of hyperandrogenism and insulin resistance, but it reports no new clinical findings.

This review of studies published after 2020 found that probiotics may significantly reduce acne lesions and improve skin health in individuals with acne vulgaris, though further high-quality research is needed for confirmation and treatment optimization.

This review highlights the role of sex hormones in skin health, observing that hormonal changes throughout a woman's life can affect skin conditions such as acne and hair loss, with treatments involving hormonal therapies and the importance of a multidisciplinary approach.

This source reviews the influence of sex hormones on skin health, detailing how hormonal fluctuations impact dermatological conditions throughout a woman's life and highlighting the necessity for integrated dermatological, gynecological, and endocrine care alongside mental health support to address these conditions' physical and psychological effects.

This review describes how sex hormones like estrogens and androgens influence skin health, linking hormonal fluctuations to conditions such as acne and hair loss, and underscores the importance of a multidisciplinary approach to treatment that includes mental health support.

This study examines the genetic underpinnings of chronic dermatological conditions like acne, androgenetic alopecia, and alopecia areata, concluding that a deep understanding of these mechanisms can advance patient-specific treatments and inform cosmetic practices related to skin and hair health.

This source highlights the potential benefits of identifying risk factors and intervening early to mitigate acne scarring and improve quality of life. It also emphasizes the importance of recognizing acne severity predictors to guide preventive strategies and optimize patient outcomes.

This review discusses the effectiveness and mechanisms of combined oral contraceptives in treating acne vulgaris but reports no new clinical results; the authors highlight their antiandrogenic effects for managing acne and related endocrine disorders.

This review provides current insights into the role of Demodex mites in acne and rosacea, detailing their involvement in sebaceous gland diseases due to their potential to cause inflammation and disrupt skin microbial balance, while suggesting methods to correct mite overgrowth.

In this study, isotretinoin, an effective treatment for severe acne, was found to significantly impact hematological, inflammatory, and oxidative stress biomarkers, suggesting potential risks alongside its therapeutic benefits.

This article reviews the management of polycystic ovarian syndrome, highlighting lifestyle modification and individualized pharmacological treatment strategies, and reports no new clinical results.

This study found that the protein C4BPA may link insulin resistance and acne vulgaris by influencing lipid metabolism and inflammatory pathways, suggesting it as a potential mediator in the pathogenesis of both conditions.

Ovarian hyperthecosis caused high testosterone and virilization symptoms in a 60-year-old woman, which improved after surgery.

This review examines the genetics of acne vulgaris, concluding that stem/progenitor cell maintenance and cellular migration are key processes in its pathogenesis, potentially shifting future treatment strategies beyond traditional antibiotics and retinoids, which have notable side effects.

Acne involves increased lipid production and inflammation, affecting skin cell behavior and treatment resistance.

This review found that prolonged use of face masks during the COVID-19 pandemic increased the incidence of facial skin conditions like maskne and dermatitis, particularly affecting women and young people, and suggests prevention and management strategies including skincare routines, mask material choice, and therapeutic approaches.

Sampling methods greatly affect skin microbiome data in acne studies.

This study found that patients with acne vulgaris had significantly lower serum paraoxonase 1 (PON1) activity compared to healthy controls, suggesting that oxidative stress might play a role in the condition's development.

In this case-control study, researchers found that serum apelin-12 levels were significantly higher in acne patients and correlated with acne severity, BMI, insulin resistance, and inflammation, suggesting that managing insulin resistance could be important for acne treatment.

This paper reviews the current evidence regarding the off-label use of spironolactone for acne management, noting that despite its long-standing application in acne treatment, it has not yet received FDA approval for this indication.

This review discusses the connection between acne and metabolic syndrome, noting shared pathogenic mechanisms and suggesting integrated management strategies without presenting new clinical results.

In this study using a rat model, researchers observed that applying topical testosterone led to changes in the skin resembling early acne lesions, indicating a dermatologic risk potentially associated with over-the-counter testosterone products.

This study discusses the importance of careful dermatological care for transgender youth receiving hormonal therapies, cautioning that acne treatments can interfere with hormone replacement therapy and emphasizing the need for a collaborative interdisciplinary approach to support both acne management and overall well-being.

In this study involving acne patients, researchers compared the effects of combined fire needle and salicylic acid therapy with conventional treatment, measuring improvements in skin lesion severity, skin barrier function, and microbiota diversity; results are not reported in the abstract.

This case study describes a 22-year-old female with acne and irregular menstrual cycles, suggesting a possible link to Polycystic Ovarian Syndrome, but reports no new clinical findings.

This study found that the Geh gene responsible for lipase enzyme production was highly expressed in Staphylococcus aureus isolates from acne patients, implicating this enzyme in the infection's pathogenesis.

This review examined evidence on non-systemic treatments for acne vulgaris and related skin complications, finding very low-certainty evidence that benzoyl peroxide may reduce lesion counts but may also increase the risk of minor adverse events, highlighting the need for higher-quality research for effective therapies.