35 citations
,
January 2017 in “Journal of Dermatological Science” This study suggests that stress-induced premature senescence of dermal papilla cells may contribute to hair follicle aging by impairing critical epithelial-mesenchymal interactions and promoting inflammatory cytokine production.
19 citations
,
August 2024 in “Journal of Translational Medicine” This review explores recent advancements in understanding how various physiological and psychological factors, such as stress and aging, influence epidermal stem cell populations, highlighting their importance in immune-related skin disorders and potential for clinical applications.
3 citations
,
March 2023 in “Life” This review discusses recent findings on wound healing with a focus on adipose tissue biology and obesity, but presents no new clinical results.
1 citations
,
July 2025 in “The Open Dermatology Journal” This study explores the transformative role of tissue engineering in cosmetics, highlighting innovations like lab-grown skin and personalized grafts that enhance product efficacy, offer ethical alternatives to animal testing, and address aesthetic issues such as scarring and aging.
This study reviews the regulatory mechanisms and molecular processes governing stem cell activity in hair follicles, highlighting their roles in hair regeneration and potential implications for treating hair and skin disorders.
This study found that the loss of papillary fibroblasts in the skin due to UV radiation is mainly caused by an uncontrolled inflammatory response, with T cells helping fibroblast survival.
108 citations
,
September 2002 in “The Journal of clinical investigation/The journal of clinical investigation” This study found that reducing testosterone levels in male mice accelerates wound healing and decreases inflammation, suggesting a potential therapeutic target for improving wound repair in elderly males.
95 citations
,
February 2018 in “Dermatology and Therapy” This review discusses the role of nutraceuticals in combating skin aging but reports no new clinical results, focusing on their mechanisms of action and potential effectiveness for dermatologists.
11 citations
,
June 2012 in “Journal of Dermatological Science” This article reviews how aging affects skin and stem cells, but it contains no new research findings.
7 citations
,
March 2023 in “Antioxidants” This study confirmed the antioxidant role of rosemary, suggesting its potential use in treating inflammatory and infectious skin conditions, but emphasizes that more large-scale controlled trials are necessary to fully understand its clinical impact.
18 citations
,
January 2017 in “Dermatologic Surgery” This review examines intrinsic and extrinsic aging impacts and presents evidence-based lifestyle recommendations to complement cosmetic procedures for enhanced antiaging outcomes, but it reports no new clinical results.
59 citations
,
November 2015 in “International Journal of Cosmetic Science” This review considers oxidative stress effects on hair aging and emphasizes the need for dermatologists to recognize and treat factors affecting scalp and hair health, but it provides no new clinical findings.
31 citations
,
February 2014 in “Journal of dermatological science” This study found that placental growth factor (PlGF) enhanced hair shaft elongation and accelerated hair follicle growth, suggesting its potential as a therapeutic target for alopecia.
4 citations
,
January 2010 in “Laboratory Animal Research” This study found that Na2SiO3 accelerated hair regrowth in mice, indicating potential for treating alopecia, though it did not significantly alter enzyme activity compared to distilled water.
January 2026 in “Frontiers in Pharmacology” This study demonstrated that SHFKO significantly accelerated healing in acute radiation-induced skin injuries, with mechanisms involving apoptosis inhibition, suppression of inflammation, and restoration of ROS balance, suggesting its potential as a novel multi-target therapy for radiodermatitis.
January 2024 in “Wiadomości Lekarskie” In this exploration, the authors discuss the challenges and potential roles of aesthetic surgery in achieving long-lasting rejuvenation, touching on societal pressures linking beauty with youth and examining how modern techniques might offer a natural, subtle appearance despite the inevitability of aging.
January 2017 in “Clinical approaches and procedures in cosmetic dermatology” This review explores the role of advanced glycation end products in skin aging and their interaction with oxidative stress, but reports no new clinical findings.
44 citations
,
October 2011 in “Gynecological Endocrinology” This review discusses the effects of oestrogen on skin ageing and highlights the need for large-scale clinical trials to evaluate postmenopausal oestrogen use, reporting no new findings.
35 citations
,
January 2013 in “The Journal of experimental medicine/The journal of experimental medicine” This study found that deleting the CD98hc protein in mouse skin impairs wound healing and homeostasis, resembling aging effects, due to disrupted integrin signaling pathways.
30 citations
,
February 2017 in “Histochemistry and Cell Biology” This study found that applying TPA to mice accelerated hair follicle regeneration by activating Akt and Wnt/ß-catenin signaling pathways, involving hair follicle stem cell proliferation.
33 citations
,
January 2018 in “The International Journal of Developmental Biology” This review discusses the dual role of cellular senescence in ageing and tissue repair and suggests potential therapeutic applications, with no new experimental results reported.
3 citations
,
July 2015 in “European Journal of Dermatology” This abstract discusses the role of advanced glycation end-products in aging-related skin damage, but does not provide new findings on their impact on alopecia.
4 citations
,
May 2020 in “Cureus” This case report describes an adult male from India with Werner's syndrome due to a novel homozygous mutation in the WRN gene, characterized by several premature aging symptoms.
3 citations
,
July 2021 in “Life science alliance” This study observed that disrupting the Pnkp gene in adult mice resulted in a premature aging-like phenotype, suggesting PNKP's vital role in maintaining normal growth and survival of certain progenitor cell populations.
1 citations
,
January 2019 in “Journal of Embryology & Stem Cell Research” This review discusses mesenchymal stem cells' role in tissue regeneration and skin anti-aging, highlighting their migration to damaged sites and secretome effects, but reports no new clinical results.
1 citations
,
January 2009 in “Elsevier eBooks” This chapter provides an overview of skin physiology, aging effects, and how environmental factors like UV damage impact skin health, without presenting new research findings.
July 2025 in “Scientific Reports” This study found that dermal papilla cell-conditioned medium can protect against UV-induced skin aging in a mouse model by modulating ferroptosis pathways, highlighting its potential for treating oxidative stress-related skin conditions.
19 citations
,
July 2015 in “Journal of Ginseng Research” In this study, Korean Red Ginseng showed protective effects against chemotherapy-induced premature hair follicle aging in an in vitro model by modulating specific cellular protein expressions.
January 2025 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that rhamnose can restore hair-inducing gene expression in dermal papilla cells and accelerate hair follicle regeneration by promoting the hair cycle into the anagen phase, suggesting its potential therapeutic application for alopecia treatment.
January 2025 in “Acta Clinica Croatica” This pilot study found that using platelet rich fibrin in combination with dressings after revascularization surgery in patients with critical limb ischemia accelerated wound healing compared to dressings alone.