9 citations
,
September 2017 in “Nanoscale Research Letters” This study found that combining TIMP-1 with graphene oxide promoted skin tissue regeneration in rats and provided sustained release of TIMP-1 over 40 days.
9 citations
,
July 2017 in “Journal of Drug Delivery Science and Technology” This study suggests that a microemulsion formulation of Minoxidil effectively enhances drug delivery through hair follicles, showing significant follicular response alterations in an alopecia model.
9 citations
,
January 2017 in “Food & Nutrition Research” In this study, rice bran mineral extract increased expression of anagen-related proteins and decreased inflammatory markers in human dermal papilla cells, suggesting potential for hair growth enhancement and prevention of hair loss.
9 citations
,
April 2016 in “Cutaneous and ocular toxicology” This study found that Alpha Lipoic Acid may help reduce cigarette smoke-induced skin damage in rats by improving collagen structure and reducing markers of oxidative stress.
9 citations
,
February 2014 in “Tissue Engineering and Regenerative Medicine” This study found that conditioned media from human amniotic fluid-derived stem cells may enhance skin regeneration by promoting cell proliferation and migration, and by modulating gene expressions altered by UV irradiation.
9 citations
,
March 2013 in “ISRN Stem Cells (Online)” This study demonstrated that human dermal mesenchymal stem cells can be differentiated into cardiomyocytes using 5-azacytidine, suggesting potential future applications for treating myocardial infarction.
9 citations
,
November 2012 in “Biomolecules & therapeutics” This study found that diphlorethohydroxycarmalol significantly increased prostaglandin $E_2$ synthesis in HaCaT human keratinocytes by upregulating COX-1 and COX-2 expression, suggesting potential benefits from elevated $PGE_2$ production.
9 citations
,
March 2009 in “European Journal of Dermatology” In this animal study, the researchers found that Schisandra nigra extract may promote hair growth by extending the anagen phase and reducing TGF-beta2 expression.
9 citations
,
January 2006 in “Cutaneous and ocular toxicology” This study found that L-cystine, D-pantothenat, and miliacin can enhance the metabolic capacity and proliferation of human keratinocytes, with a combination of these additives potentially providing synergistic benefits in growth media.
9 citations
,
October 1993 in “The Journal of Clinical Pharmacology” Finasteride doesn't affect antipyrine metabolism, so interactions with cytochrome P-450 enzyme drugs are unlikely.
8 citations
,
February 2025 in “Frontiers in Medicine” This study suggests that using growth factors and ADSC-conditioned medium can enhance keratinocyte viability and migration in epidermal transplantation, potentially improving chronic wound healing rates with a patient-dependent effect.
8 citations
,
November 2024 in “Scientific Reports” In this study, different drying methods for Hedychium spicatum rhizomes significantly affected the essential oil yield, antioxidant potential, and compound composition, with the HSOV30 method yielding the highest oil content, antioxidant activity, and specific compound levels such as 1,8-cineole and elemol.
8 citations
,
July 2024 in “Scientific Reports” This study reported that administering salicylates to wounds in adult mice promoted wound healing patterns similar to embryonic wounds, enabling complete wound regeneration and reduced scarring by activating AMPK and subsequent signaling pathways.
8 citations
,
October 2023 in “Folia Histochemica et Cytobiologica” This study observed that exosomes from adipose mesenchymal stem cells overexpressing hepatocyte growth factor significantly improved liver function and reduced fibrosis in mice with experimentally induced liver injury.
8 citations
,
May 2022 in “International journal of nanomedicine” This study developed a fully natural resveratrol nanoparticle system using lecithin, showing potent anti-cancer activity in vitro and increased tumoral uptake in vivo on breast cancer models.
8 citations
,
May 2021 in “Applied Materials Today” This study found that Cur-Fe-mesoporous silica nanoparticles synergistically inhibited scar formation and promoted hair follicle regeneration in skin burn wound healing by releasing bioactive components like SiO32−, Fe3+, and Fe-Cur chelates.
8 citations
,
January 2021 in “Smart materials in medicine” This study found that a newly constructed composite hydrogel dressing, made from silk fibroin, chitosan, and halloysite, promoted hair follicle neogenesis, angiogenesis tissue regeneration, and scar reduction.
8 citations
,
October 2020 in “International Journal of Molecular Sciences” This laboratory study found that nonanal, a plant scent compound, may stimulate growth factors and cell proliferation in human hair follicle dermal papilla cells, suggesting a cAMP-mediated mechanism.
8 citations
,
October 2020 in “Pharmaceutics” This study explored using a chitosan oligomer coating for topical delivery of dutasteride-loaded nanostructured lipid carriers, aiming to reduce systemic exposure and cytotoxicity.
8 citations
,
July 2019 in “Pure and Applied Chemistry” This study identified natural compounds from Iris plants that showed potential as inhibitors of urease and carbonic anhydrase-II enzymes, suggesting their possible use in treating related disorders.
8 citations
,
June 2019 in “Journal of Ginseng Research” This study found that a gintonin-enriched fraction from ginseng promoted hair growth in mice by stimulating dermal papilla cell proliferation and increasing hair follicles and weight.
8 citations
,
April 2019 in “ACS Biomaterials Science & Engineering” This study found that a new SIS-PEG sponge promoted rapid skin defect healing in mice and showed potential for reconstructing reconstituted skin with regenerated hair.
8 citations
,
October 2018 in “Dermatologic Therapy” In this study of Indian patients with pattern hair loss, 40.8% showed low sulfotransferase enzyme activity in hair follicles, with a higher prevalence of low activity in men compared to women.
8 citations
,
September 2017 in “Journal of Natural Medicines” This study reported that the n-butanol fraction of Perilla frutescens extract, particularly rosmarinic acid, showed potential for hair regrowth and anti-androgenic activity in male mice, suggesting it as a possible treatment for androgenetic alopecia.
8 citations
,
May 2017 in “Chinese Journal of Integrative Medicine” Among in vitro and in vivo models, this study found that Miscanthus sinensis var. purpurascens flower extract may promote hair growth, potentially by modulating growth factor expressions and facilitating earlier hair follicle transitions in treated mice.
8 citations
,
January 2017 in “Stem Cells International” This study found that overexpression of sFRP4 in skin cells reduces Wnt signaling activation, leading to decreased melanocyte differentiation in regenerating hair follicles.
8 citations
,
January 2016 in “Journal of Veterinary Medical Science” This study found that canine adipose-derived mesenchymal stem cell-derived dermal papilla-like tissues promoted new hair follicle formation and increased vascularization in mice, suggesting potential for hair regeneration.
8 citations
,
January 2016 in “Journal of fiber science and technology” This study found that cysteic acid generation during hair bleaching is diffusion-controlled, increasing with the square root of bleaching time, in both cuticles and cortex of human hair fibers.
8 citations
,
February 2015 in “Cellular immunology” This study found that deleting Snai2 and Snai3 genes in mice disrupts immune cell development, resulting in severe autoimmunity and early death due to the loss of immune tolerance.
8 citations
,
February 2014 in “General and Comparative Endocrinology” In this study, exposure to the drug finasteride in Silurana tropicalis significantly increased testosterone levels in liver and testis tissues and altered gene expression related to male reproduction and oxidative stress.