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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.

Hormone therapy for trans individuals is effective and generally safe in the short term.

Lifestyle changes can improve body composition, excess male hormone levels, and insulin resistance in women with PCOS.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

Men are more likely to have severe COVID-19 cases and fatalities than women due to factors like lifestyle, aging, and biological differences.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Different types of skin cells have unique genetic markers that affect how likely they are to spread cancer.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Low iron levels may be linked to some types of hair loss in women.

New insights show Lichen Planopilaris is a rare, scarring hair loss condition, hard to treat, mainly affecting middle-aged women, and significantly impacts mental health.

Stress-related substance P may lead to hair loss and negatively affect hair growth.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

The document concludes that recognizing and treating cutaneous lupus erythematosus early is crucial for managing the skin and potential systemic symptoms.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

The document concludes that accurate diagnosis of ichthyosis is crucial for treatment and genetic advice, and ongoing research is needed for better therapies.

Some drugs can cause hair loss or increase hair growth, but these effects are usually reversible when the drug is stopped.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.

Some vitamins and minerals like vitamin D and iron can help with certain types of hair loss, but more research is needed for others.

Adam10 enzyme is crucial for healthy skin and proper Notch signaling.

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.

Isotretinoin effectively treats severe acne and similar conditions, but has common, mostly reversible side effects, requiring careful patient monitoring.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

No single treatment is consistently effective for alopecia areata, and more research is needed.

Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.

Combining liraglutide and metformin helps obese women with PCOS who didn't lose weight on metformin alone to lose more weight.

People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.