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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.

Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Inhaling medicine may reduce side effects and improve treatment for a major lung cancer type.

Glucocorticoids for progressive muscular dystrophy in children don't improve muscle strength or function but do increase certain side effects.

Nonobese, normotensive Indian women with PCOS may have a higher risk of heart problems linked to inflammation and insulin resistance.

The document concludes that proper recognition and treatment of skin appendage disorders are important for management.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

The Rotterdam Study aims to understand various diseases in older adults.

Adult female acne treatment should be personalized, considering individual preferences and pregnancy, using various topical and oral medications while managing side effects and resistance.

Fetal wound healing changes with development, affecting inflammation and collagen, which may influence scarring.

Progestogens are essential in menopausal hormone therapy to prevent uterine cancer and must be chosen carefully based on individual needs.

Certain gene variations increase the risk of alopecia areata in Koreans.

Patients with both connective tissue disease and acid reflux are more likely to have certain symptoms and physical signs.

Testosterone replacement therapy improves libido, mood, muscle strength, and bone density in men with Testosterone Deficiency Syndrome.

Lysophospholipids like LPA and S1P are important for hair growth, immune responses, and vascular development, and could be targeted for treating diseases.

Plasma-activated liquid can kill harmful cells, speed up wound healing, and potentially treat cancer without damaging healthy cells.

Obesity leads to physical, metabolic, reproductive issues, higher healthcare costs, and mental health problems.

ACBP is essential for healthy skin and fur by maintaining the skin's barrier function.

Prostaglandin D2 blocks new hair growth after skin injury through the Gpr44 receptor.

Feather patterns form through genetic and epigenetic controls, with cells self-organizing into periodic patterns.

Increasing miR-149 reduces hair follicle stem cell growth and hair development by affecting certain cell growth pathways.

Metformin, a diabetes drug, may help prevent and treat various cancers, but more research is needed.

FoxN1 overexpression in young mice harms immune cell and skin development.

GRK2 is essential for healthy hair follicle function, and its absence can lead to hair loss and cysts.

sPLA2-X is crucial for normal hair growth and follicle health.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Overexpressing Dsg3 in mice skin causes excessive cell growth and abnormal skin development.

KGF and activin are crucial for skin healing and repair.