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The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.

Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

Inherited ichthyoses cause widespread skin scaling and thickening due to gene mutations.

White lupin uses specific genes to grow root hairs and access phosphorus when it's scarce.

Methotrexate is a key, cost-effective drug for skin conditions, but requires careful monitoring for side effects.

Human hair follicles produce and respond to erythropoietin, helping protect against stress.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

European guidelines recommend regular eye and ear exams, skin care, vitamin D supplements, and cautious use of medications for managing congenital ichthyoses.

ZDHHC13 is important for normal liver function and metabolism, affecting mitochondrial activity.

SHBG may be a useful early indicator and treatment target for PCOS.

The guide explains how to study human and mouse sebaceous glands using various staining and imaging techniques, and emphasizes the need for standardized assessment methods.

Different factors affect where drugs are absorbed in the small intestine, which is important for effective medication use.

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

Androgen receptor activity blocks Wnt/β-catenin signaling, affecting hair growth and skin cell balance.

Plant steroid hormones show growth, health, and medicinal benefits in various organisms, including potential for treating diseases.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Eph/ephrin signaling is important for skin cell behavior and could be targeted to treat skin diseases.

Adrenal disorders can cause lasting brain and behavior issues in children.

Graphene oxide and indole-3-acetic acid together inhibit root growth in Brassica napus L. by affecting multiple plant hormone pathways.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

Cheonggukjang may help prevent and manage various diseases and improve overall health, but its odor and safety concerns need addressing.

An enzyme other than TNAP might be responsible for vitamin B-6 metabolism in the skin.

Allopregnanolone increases growth and changes gene activity in human brain cancer cells.