48 citations
,
January 2014 in “Dermatology Online Journal” This review examines various treatments for dissecting cellulitis, noting isotretinoin may offer the best chance for remission despite limited long-term data and calls for more clinical studies.
47 citations
,
April 2020 in “Dermatologic Therapy” This letter discusses the potential connection between androgenetic alopecia and COVID-19, suggesting a possible new therapy, but it reports no new results.
46 citations
,
January 2005 in “PubMed” This paper discusses risk factors and prevention strategies for acute urinary retention secondary to benign prostatic hyperplasia, emphasizing the role of PSA levels and the benefits of medications like finasteride and alpha-blockers, but reports no new clinical results.
45 citations
,
March 2015 in “Clinical Endocrinology” This article reviews the use of cross-sex hormonal therapy in transmen and reports that it is reasonably safe, suggesting monitoring should be frequent initially but can be less frequent over time.
45 citations
,
August 2005 in “Bioorganic & medicinal chemistry” This study found that novel androgen antagonists incorporating a carborane moiety showed anti-androgenic activity comparable to flutamide in a laboratory setting.
43 citations
,
December 2006 in “The American journal of pathology” This study found that Edar signaling plays a role in regulating the hair cycle and apoptosis in hair follicle keratinocytes during the catagen phase in mice.
35 citations
,
June 2015 in “Pediatrics in Review” This article discusses hyperthyroidism in children, highlighting Graves' disease as the most common cause, and underscores the importance of timely diagnosis and intervention to mitigate morbidity; no new clinical results are reported.
35 citations
,
May 2002 in “Journal of the European Academy of Dermatology and Venereology” This review highlights that current diagnostic and treatment methods for chronic pelvic pain syndrome lack robust evidence, suggesting a need for further research.
30 citations
,
September 2016 in “BMJ” This study found that 5-α reductase inhibitors do not significantly increase the risk of erectile dysfunction in men with benign prostatic hyperplasia or alopecia, although duration of benign prostatic hyperplasia may elevate risk.
30 citations
,
May 1991 in “Psychosomatics” This review examines alopecia as a side effect of psychotropic medications, noting that it is typically reversible after stopping the drug, but it reports no new results.
26 citations
,
December 2023 in “Prostate International” This review provides an overview of the risks and side effects associated with common medications used to treat benign prostatic hyperplasia, highlighting the importance for clinicians and patients to discuss these aspects for informed decision-making.
26 citations
,
August 2016 in “Translational Andrology and Urology” This review discusses the impact of medical and surgical treatments for LUTS/BPH on ejaculatory function, highlighting that most treatments negatively affect it, except for some minimally invasive surgical therapies and specific medical therapies.
25 citations
,
September 2014 in “Pharmacotherapy” This review covers cross-sex hormone therapy for gender dysphoria, noting improvements in psychological symptoms and quality of life but lacking definitive long-term safety data.
22 citations
,
June 2011 in “Acta Ophthalmologica” This study found that current use of benzodiazepines, α1-blockers (like tamsulosin, alfuzosin, terazosin), finasteride, and possibly rivastigmine is associated with increased risk of intraoperative floppy iris syndrome in cataract surgery patients.
21 citations
,
January 2005 in “Skinmed” This article reviews the structural similarities and common disorders of hair and nails, highlighting their joint involvement in congenital and acquired conditions, but it reports no new clinical results.
20 citations
,
May 2018 in “The Journal of Urology” This study concluded that 5α-reductase inhibitors were associated with improved survival in men with bladder cancer, while α-blockers showed no effect.
20 citations
,
December 2015 in “Der Urologe” Combining medications is more effective for treating benign prostatic syndrome symptoms.
20 citations
,
January 2004 in “PubMed” This review discusses the pharmacologic effects, safety, and efficacy of dutasteride and finasteride for BPH, finding similar clinical benefits but greater DHT reduction with dutasteride and reports no new trial results.
19 citations
,
June 2017 in “Asian journal of urology” This review discusses the stratification and management of male patients with lower urinary tract symptoms and benign prostatic hyperplasia in primary care and reports no new clinical results.
19 citations
,
July 1990 in “Cleveland Clinic journal of medicine” This article reviews endocrine therapies for androgen excess disorders, emphasizing spironolactone, estrogen, and dexamethasone as effective treatments; it reports no new clinical results.
18 citations
,
November 2021 in “Anais Brasileiros de Dermatologia” This review examines the skin manifestations associated with COVID-19 but reports no new clinical findings, emphasizing the need for differential diagnoses to correlate skin symptoms with the virus.
17 citations
,
January 1995 in “The American Journal of Medicine” This review discusses the management of androgenic disorders in women, highlighting that treatment is generally more effective than recognized, though improvement may take weeks or months to appear.
16 citations
,
January 2003 in “Nuclear Receptor Signaling” Androgens and SARMs play a role in body mass, frailty, skin health, and hair growth, and are used in treating prostate cancer, acne, and hair loss, with potential for new uses and improved versions in the future.
16 citations
,
December 2011 in “Actas Dermo-Sifiliográficas” This review discusses the current understanding of propranolol's use in treating infantile hemangiomas, covering its indications, effectiveness, side effects, and ongoing clinical trials, without presenting new clinical results.
15 citations
,
March 2021 in “Journal of clinical medicine” This review discusses common skin eruptions caused by biologics in treating inflammatory bowel disease and proposes tailored therapeutic approaches for managing these adverse reactions.
15 citations
,
July 2016 in “Urologic Clinics of North America” This study found that combining 5-alpha reductase inhibitors with alpha-blockers provided the best symptomatic relief and reduced the risk of clinical progression for BPH, while PDE5 inhibitors could offset sexual side effects.
15 citations
,
November 1994 in “International Journal of Dermatology” This study found that while the combination of oral propranolol and intradermal injections in guinea pigs led to psoriasiform changes, it did not fully mimic psoriasis.
14 citations
,
January 2020 in “Archivio Italiano di Urologia e Andrologia” This review found that finasteride monotherapy for managing LUTS/BPH significantly reduced prostate volume and improved symptoms, with sexual dysfunctions reported as notable side effects compared to placebo, but emphasizes the need for more comprehensive studies.
14 citations
,
November 2006 in “Current Medicinal Chemistry” This review discusses recent developments in α1-adrenoceptor antagonists and 5α-reductase inhibitors for treating benign prostatic hyperplasia, reporting no new clinical results while identifying potential areas for future drug development.
14 citations
,
February 2021 in “Experimental Dermatology” This study found that activating CB1 receptor signaling in human hair follicles increased stem cell proliferation while reducing differentiated cell survival, suggesting CB1's role as a survival stimulus for epithelial stem cells.