August 2024 in “Latin American Journal of Development” In this review, the authors highlight the involvement of the 5α-reductase enzyme family in androgen-dependent disorders, noting the discovery of a novel isoform, SRD5A3, which is overexpressed in cancers with poor prognosis.
This study concluded that monthly intralesional autologous platelet-rich plasma therapy significantly decreased alopecia areata severity over four months compared to daily 5% topical minoxidil therapy.
June 2024 in “Skin Appendage Disorders” In this study, injections of PRP and MZT products significantly improved hair thickness, density, and count in AGA patients over six months, with variability observed in the extent of improvement between different formulations.
In this study, baricitinib was used as monotherapy to treat a 21-year-old woman with severe alopecia areata, resulting in significant hair regrowth and reduced alopecia severity within three months, suggesting its effectiveness and potential as a robust treatment option for this condition.
January 2024 in “Photodiagnosis and Photodynamic Therapy” The study found that combining a 655nm low-level laser helmet with 2% minoxidil resulted in better improvement in hair diameter and intermediate hair enlargement at the midscalp among Chinese women with FPHL.
December 2023 in “Dermatology and therapy” This study observed that patient-physician alignment on alopecia areata severity largely followed Japanese Dermatological Association criteria, yet alignment on treatment satisfaction was lower, with lack of efficacy as the main dissatisfaction reason.
October 2023 in “Journal of Medicine, University of Santo Tomas (JMUST Online)” This study reported that among Filipino elderly patients, xerosis/xerotic eczema was the most common dermatological condition leading to consultation, with inflammatory dermatoses being the predominant category of skin diseases observed from 2014 to 2018 at a tertiary hospital's dermatology service.
January 2023 in “International Journal of Molecular Sciences” This review discusses the biologically active compounds in Maxillariinae orchids, highlighting 62 semiochemicals with medical potential, but reports no new clinical findings.
May 2015 in “Journal of The American Academy of Dermatology”
9 citations
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July 2020 in “Journal of Dermatology” This study found that diffuse and pseudo-fringe sign patterns are common in Asian patients with frontal fibrosing alopecia, and that treatments combining antiandrogens or antimalarials with topical therapy are effective.
4 citations
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January 2019 in “PubMed” This study found that women with female pattern hair loss had significant hormonal imbalances, specifically involving adrenal androgens, suggesting these may play a central role in the condition's development.
1 citations
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April 2024 in “Skin research and technology” This clinical trial found that topical rosuvastatin and melatonin creams significantly reduced the severity of mild to moderate plaque psoriasis over 12 weeks, with a satisfactory safety profile.
April 2026 in “Cosmetics” In this randomized, double-blind, placebo-controlled trial, researchers found that a multi-targeted cosmetic formulation containing TrinogeniX™ significantly increased hair density and thickness in individuals with androgenetic alopecia without adverse effects, suggesting it as a potential safe and effective treatment option.
This case report details a 28-year-old male who developed trichotillomania following a traumatic brain injury, highlighting diagnostic challenges in distinguishing overlapping psychiatric and compulsive behaviors, and underscores the importance of a comprehensive, multidisciplinary treatment approach.
February 2026 in “Bioengineering” This study concluded that repeated platelet-rich plasma injections provided greater and more consistent improvements in stress urinary incontinence symptoms compared to pelvic floor muscle training.
January 2026 in “Behavioral Sciences” In this observational study, among 135 Italian outpatients with alopecia areata, OCD symptoms were prevalent in 18.5%, and emotional distress was found in 20.7%, with emotional distress mediating the relationship between illness perceptions and OCD symptomatology.
January 2024 in “Wiadomości Lekarskie” This report highlights that a coherent vision and collaboration are needed in Poland to address healthcare workforce shortages, including allowing domestic academic titles to confirm Polish language proficiency.
71 citations
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July 2015 in “The Journal of Clinical Endocrinology and Metabolism” This study found that women with PCOS have elevated serum androgen levels throughout adulthood, with these levels decreasing and variations increasing as they approach menopause.
58 citations
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June 2000 in “The Journal of Steroid Biochemistry and Molecular Biology” This study found that Atlantic croaker nuclear androgen receptors AR1 and AR2 have different binding affinities for androgens, suggesting that they may mediate distinct physiological actions in teleosts.
57 citations
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November 2006 in “International Journal of Cancer” This study found that the SRD5A2 A49T A variant is associated with an increased risk of prostate cancer, lower circulating 3α‐diolG levels, and a decreased risk of baldness.
45 citations
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January 2012 in “The Journal of Steroid Biochemistry and Molecular Biology” This study found that overexpression of AKR1C3 in prostate cancer cells redirected androgen metabolism towards testosterone production, which facilitated cell proliferation, potentially reducing the effectiveness of finasteride treatment.
36 citations
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October 2019 in “Cell Proliferation” This study reported that tryptanthrin, a compound found in indigo naturalis, effectively suppresses non-melanoma skin cancer in mice by reducing inflammation, inhibiting cell proliferation, and blocking specific signaling pathways associated with tumor growth.
28 citations
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April 2014 in “Hormones” This study found that increased serum A4A levels were associated with more severe polycystic ovary syndrome phenotypes and could be a useful marker for biochemical hyperandrogenemia.
23 citations
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June 2012 in “PLOS ONE” This study found that KLF4 expression in mouse hair follicle stem cells is important for effective cutaneous wound healing, with its knockdown leading to reduced stem cell populations and delayed healing.
22 citations
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January 2019 in “Hormone and Metabolic Research” This meta-analysis confirmed associations between some androgenic and metabolic parameters in women with PCOS, suggesting that these measurements might help predict metabolic risk in this population.
19 citations
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January 2017 in “Hormone Molecular Biology and Clinical Investigation” This study found a high prevalence of hyperandrogenemia in women with PCOS, with distinct biochemical differences according to BMI and presence of hyperandrogenemia.
15 citations
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August 1991 in “Histochemistry and Cell Biology” Enhancing Factor is found in growing tissues like young mouse intestines and skin but not in adults.
2 citations
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January 2023 in “Research Square (Research Square)” This study found that obesity, insulin resistance, and hyperandrogenism increase the risk of depression and food cravings in women with PCOS, exacerbating obesity and metabolic syndrome.
April 2025 in “Middle East Fertility Society Journal” This study established reference values for nine fertility hormones important in diagnosing and monitoring PCOS in Pakistani and other subcontinent populations.
February 2024 in “Biomedicines” This review examines the hormonal causes of hair loss, noting how androgen excess can lead to follicle miniaturization and linking estrogen deficiency and thyroid dysfunction to common alopecia types. It further discusses hormonal treatments such as finasteride, dutasteride, and spironolactone.