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Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Riboflavin 5′-phosphate (FMN) shows potential for treating androgen-related conditions but may be limited in treating prostate cancer.

The scalp fat tissue of men with hair loss shows changes in gene activity that may contribute to their condition.

DHT in the human prostate is produced through multiple pathways, not just from testosterone.

Muscles can make their own androgens, which may help muscle growth.

Managing side effects of endocrine therapy is crucial to improve adherence and survival in breast cancer patients.

Hair loss in men may be caused by inflammation triggered by hormones, and treatments reducing inflammation could potentially promote hair growth.

Oleanolic acid improved hair growth in mice by affecting hair growth pathways and reducing inflammation.

Cantú syndrome is caused by mutations in the ABCC9 gene.

PPARγ is crucial for skin health but can have both beneficial and harmful effects.

High doses of cyproterone acetate increase the risk of brain tumors in women, but the risk decreases after stopping the medication.

The document concludes that more research is needed to find effective treatments for Lichen planopilaris and Frontal fibrosing alopecia.

Testosterone, progesterone, and levonorgestrel change enzyme levels related to fat production in hamster skin, which could affect skin oil and acne.

The enzyme sEH is important for hair growth and its inhibition could help treat hair loss.

Cyproterone slightly inhibited hair growth in castrated mice, while tamoxifen significantly inhibited hair growth in castrated mice but not in normal mice.

SLVs help maintain muscle stretch sensitivity and could aid in treating hypertension and muscle spasticity.

Sex hormones may affect COVID-19 severity, with estrogen possibly reducing risk and testosterone potentially increasing it.

δ-GABAA receptors affect alcohol consumption based on the estrous cycle and influence movement regardless of the cycle.

GLI1 might protect against the start of skin cancer and is not linked to cancer severity.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

Toll-like receptors are important for wound healing, but can slow it down in diabetic wounds.

Testing for CAG repeat polymorphism in the androgen receptor gene is not currently recommended for managing hypogonadism.

Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.

The more lipophilic the progesterone derivative, the better it binds to androgen receptors and has antiandrogenic effects.

A boy with a rare form of early puberty caused by a new gene mutation responded well to treatment aimed at reducing testosterone and preserving adult height.

A woman with a skin disorder was found to have hepatitis C, which may be linked, and was safely treated with methotrexate.

A transwoman developed a brain tumor after nine years of hormone therapy, suggesting a possible link between the treatment and tumor development.

Mutations in certain receptors can cause diseases and offer new treatment options.

Flutamide works better than finasteride for hirsutism, and combining both is slightly better but not much.