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    Glossary Valproic Acid

    medication used to treat epilepsy and bipolar disorder

    Valproic Acid, also known as VPA or by brand names like Depakote, is a medication primarily used to treat epilepsy, bipolar disorder, and to prevent migraine headaches. It works by increasing the levels of certain neurotransmitters in the brain, which helps stabilize electrical activity and mood. Additionally, Valproic Acid has been studied for its potential effects on hair growth, as it may influence pathways involved in hair follicle cycling.

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    1. Valproic acid. A reappraisal of its pharmacological properties and clinical efficacy in epilepsy. PubMed · 1994 · 294 citations
    2. Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012 · 85 citations
    3. Low Serum Biotinidase Activity in Children with Valproic Acid Monotherapy Epilepsia · 2001 · 73 citations
    4. Pancreatitis associated with valproic acid therapy for epilepsy Annals of Neurology · 1980 · 73 citations
    5. Transcutaneous implantation of valproic acid-encapsulated dissolving microneedles induces hair regrowth Biomaterials · 2018 · 68 citations
    6. Valproic acid promotes human hair growth in in vitro culture model Journal of Dermatological Science · 2013 · 48 citations
    7. Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells Journal of immunology research · 2019 · 47 citations
    8. Topical valproic acid increases the hair count in male patients with androgenetic alopecia: A randomized, comparative, clinical feasibility study using phototrichogram analysis Journal of Dermatology · 2014 · 37 citations
    9. The influence of valproic acid treatment on hair and serum zinc levels and serum biotinidase activity European journal of paediatric neurology · 2008 · 36 citations
    10. Valproic acid reduces hair loss and improves survival in patients receiving temozolomide-based radiation therapy for high-grade glioma European Journal of Clinical Pharmacology · 2016 · 26 citations
    11. Valproic Acid (Depakene) JAMA · 1978 · 24 citations
    12. The effects of biotin supplementation on serum and liver tissue biotinidase enzyme activity and alopecia in rats which were administrated to valproic acid Brain & development · 2008 · 22 citations
    13. The Influence of Valproic Acid and Carbamazepine Treatment on Serum Biotin and Zinc Levels and on Biotinidase Activity Journal of child neurology · 2011 · 21 citations
    14. Valproic acid in childhood epilepsy: anticonvulsive efficacy in relation to its plasma levels. PubMed · 1980 · 17 citations
    15. Serum Biotinidase Activity in Children Treated With Valproic Acid and Carbamazepine Journal of child neurology · 2009 · 16 citations
    16. Valproic acid teratogenicity in whole embryo culture is not prevented by zinc supplementation Biochemical Pharmacology · 1986 · 16 citations
    17. Serum and liver tissue biotinidase enzyme activity in rats which were administrated to valproic acid Brain & development · 2006 · 15 citations
    18. Risk of valproic acid-related alopecia: A systematic review and meta-analysis Seizure · 2019 · 13 citations
    19. Valproic Acid–induced Hair‐texture Changes in a White Woman Epilepsia · 2007 · 13 citations
    20. Investigating the synergic effects of valproic acid and crocin on BDNF and GDNF expression in epidermal neural crest stem cells Acta Neurobiologiae Experimentalis · 2020 · 10 citations
    21. Hyperactivity and alopecia associated with ingestion of valproic acid in a cat Journal of the American Veterinary Medical Association · 2001 · 9 citations
    22. A case of androgenetic alopecia treated with valproic acid International Journal of Dermatology · 2013 · 6 citations
    23. [Valproic acid, curly hair and weight gain]. PubMed · 1986 · 6 citations
    24. Sterile matrix grafting for onycholysis in the setting of valproic acid use JAAD Case Reports · 2015 · 4 citations
    25. [Adverse effects of valproic acid in epileptic infants and adolescents]. PubMed · 1993 · 4 citations
    26. Valproic acid and alopecia: A two-edged sword Asian Journal of Psychiatry · 2017 · 2 citations
    27. Valproic acid (Depakene). A new anticonvulsant agent JAMA · 1978 · 2 citations
    28. Fabrication of carboxymethyl cellulose/hyaluronic acid/polyvinylpyrrolidone composite pastes incorporation of minoxidil-loaded ferulic acid-derived lignin nanoparticles and valproic acid for treatment of androgenetic alopecia International Journal of Biological Macromolecules · 2023 · 1 citations
    29. USE OF VALPROIC ACID FOR THE TREATMENT OF NEUROPSYCHIATRIC SYMPTOMS IN ACQUIRED BRAIN INJURIES Acta Neuropsychologica · 2020 · 1 citations
    30. Management Strategies for Valproic Acid-Associated Alopecia Open Science Framework · 2026