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    Glossary Setipiprant

    Setipiprant is an investigational oral medication that acts as a selective antagonist of the prostaglandin D2 receptor (DP2), which is implicated in hair loss, particularly androgenetic alopecia. By blocking this receptor, setipiprant aims to inhibit the signaling pathways that contribute to hair follicle miniaturization and hair thinning. Its relevance lies in its potential to promote hair regrowth and improve hair density in individuals experiencing hair loss, distinguishing it from other treatments that may target different biological mechanisms. Ongoing clinical trials are assessing its efficacy and safety in the context of hair restoration.

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    Research 30 of 32

    1. Does Inhibition of Aldose Reductase Contribute to the Anti-Inflammatory Action of Setipiprant? Physiological Research · 2017 · 6 citations
    2. Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1<i>H</i>-pyrido[4,3-<i>b</i>]indol-5(2<i>H</i>)-yl)acetic Acid (Setipiprant/ACT-129968) Journal of Medicinal Chemistry · 2015 · 6 citations
    3. Setipiprant for Androgenetic Alopecia in Males: Results from a Randomized, Double-Blind, Placebo-Controlled Phase 2a Trial Clinical, Cosmetic and Investigational Dermatology · 2021 · 3 citations
    4. A bald statement - Current approaches to manipulate miniaturisation focus only on promoting hair growth Experimental Dermatology · 2018 · 30 citations
    5. New drugs under investigation for the treatment of alopecias Expert Opinion on Investigational Drugs · 2019 · 26 citations
    6. The state‐of‐the‐art in the management of androgenetic alopecia: A review of new therapies and treatment algorithms JEADV Clinical Practice · 2022 · 1 citations
    7. Topical Prostaglandin Analogues in Androgenetic Alopecia: A Systematic Review of Clinical Evidence International Journal of Drug Delivery Technology · 2026
    8. The physiological and pharmacological roles of prostaglandins in hair growth The Korean Journal of Physiology and Pharmacology · 2022
    9. <i>peri</i> ‐Xanthenoxanthene (PXX): a Versatile Organic Photocatalyst in Organic Synthesis Advanced synthesis & catalysis · 2021 · 11 citations
    10. ADVANCEMENTS IN TREATMENT STRATEGIES FOR ANDROGENETIC ALOPECIA: NOVEL THERAPIES AND FUTURE PERSPECTIVES International Journal of Innovative Technologies in Social Science · 2025
    11. Female pattern hair loss: A clinical, pathophysiologic, and therapeutic review International Journal of Women's Dermatology · 2018 · 66 citations
    12. A review of the treatment of male pattern hair loss Expert Opinion on Pharmacotherapy · 2020 · 53 citations
    13. Conventional and novel stem cell based therapies for androgenic alopecia Stem cells and cloning · 2017 · 22 citations
    14. Novedades terapéuticas en tricología Actas Dermo-Sifiliográficas · 2017 · 20 citations
    15. New Treatments for Hair Loss Actas Dermo-Sifiliográficas · 2017 · 7 citations
    16. Clinical Trials and Hair Loss Elsevier eBooks · 2018 · 1 citations
    17. Use of Castor Oil in Dermatology: A Narrative Review Cureus · 2026
    18. A decade of progress in androgenetic alopecia management: Emerging therapies and multimodal strategies IP Indian Journal of Clinical and Experimental Dermatology · 2025
    19. Trends and techniques: a statistical review of hair care product evaluation research International Journal of Research in Dermatology · 2025
    20. Current Landscape and Emerging Therapies in Hair Loss Treatment for Androgenetic Alopecia EMJ Dermatology · 2024
    21. Comprehensive transcriptome profiling between balding and non-balding scalp of female pattern hair loss in Asian Archives of Dermatological Research · 2024
    22. Analysis of Female Pattern Hair loss Journal of emerging technologies and innovative research · 2019
    23. Female pattern hair loss—An update Indian Dermatology Online Journal · 2020 · 12 citations
    24. QR678 & QR678 Neo Hair Growth Formulations: A Cellular Toxicity & Animal Efficacy Study Plastic and reconstructive surgery. Global open · 2020 · 7 citations
    25. Androgenetic Alopecia: Clinical Treatment Springer eBooks · 2019 · 2 citations
    26. Molecular Mechanisms and Targeted Therapeutics in Androgenetic Alopecia: From Signaling Pathways to Regenerative Approaches Premier journal of science. · 2026
    27. Comprehensive Review on Hair Loss and Restorative Techniques: Advances in Diagnostic, Artistry, and Surgical Innovation Cureus · 2025
    28. Clinical and preclinical approach in AGA treatment: a review of current and new therapies in the regenerative field Stem Cell Research & Therapy · 2024
    29. Female Pattern Hair Loss: An Overview with Focus on the Genetics Genes · 2023
    30. New Drugs for Alopecias 2019