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    Glossary Saw Palmetto

    inhibits an enzyme linked to hair loss and prostate issues

    Saw Palmetto, also known as Serenoa repens, is a type of palm plant whose berries are often used in supplements aimed at promoting prostate health and potentially reducing hair loss. It is believed to work by inhibiting the enzyme 5-alpha-reductase, which converts testosterone to dihydrotestosterone (DHT), a hormone linked to both benign prostatic hyperplasia (BPH) and androgenic alopecia (male pattern baldness).

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    1. A Prospective, 1-Year Trial Using Saw Palmetto Versus Finasteride in the Treatment of Category III Prostatitis/Chronic Pelvic Pain Syndrome The Journal of Urology · 2004 · 105 citations
    2. Potency of a novel saw palmetto ethanol extract, SPET-085, for inhibition of 5α-reductase II Advances in Therapy · 2010 · 46 citations
    3. Inhibition of Inflammatory Gene Expression in Keratinocytes Using a Composition Containing Carnitine, Thioctic Acid and Saw Palmetto Extract Evidence-based Complementary and Alternative Medicine · 2009 · 22 citations
    4. Sensitization to saw palmetto and minoxidil in separate topical extemporaneous treatments for androgenetic alopecia Australasian Journal of Dermatology · 2002 · 17 citations
    5. Natural Hair Supplement: Friend or Foe? Saw Palmetto, a Systematic Review in Alopecia Skin appendage disorders · 2020 · 8 citations
    6. Saw Palmetto Extract Inhibits Metastasis and Antiangiogenesis through STAT3 Signal Pathway in Glioma Cell Evidence-based Complementary and Alternative Medicine · 2015 · 6 citations
    7. Effect of Saw Palmetto Supplements on Androgen-Sensitive LNCaP Human Prostate Cancer Cell Number and Syrian Hamster Flank Organ Growth Evidence-based complementary and alternative medicine · 2016 · 6 citations
    8. Saw palmetto and finasteride in the treatment of category-iii prostatitis/chronic pelvic pain syndrome Current Urology Reports · 2005 · 5 citations
    9. Serenoa Repens (Saw Palmetto) for Lower Urinary Tract Symptoms (LUTS): The Evidence for Efficacy and Safety of Lipidosterolic Extracts. Part III Uro · 2021 · 3 citations
    10. Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system Research and reports in urology · 2016 · 3 citations
    11. Homologous recombination induced by doxazosin mesylate and saw palmetto in the <i>Drosophila</i> wing‐spot test 2011 · 3 citations
    12. Lipid Profile and 5α-Reductase Inhibition Activity of Proprietary Ultrahigh-Pressure Supercritical Carbon Dioxide and Hexane Saw Palmetto Extracts Uro · 2023 · 2 citations
    13. Serenoa repens (Saw palmetto) for Lower Urinary Tract Symptoms (LUTS): The Evidence for Efficacy and Safety of Lipidosterolic Extracts. Part I Uro · 2021 · 2 citations
    14. Development of Nanoliposomes Loaded with Carbon Dioxide <i>Serenoa repens</i> (Saw Palmetto) Extract Journal of nanoscience and nanotechnology · 2021 · 2 citations
    15. Influence of Saw palmetto and Pygeum africana extracts on the urinary concentrations of endogenous anabolic steroids: Relevance to doping analysis Phytomedicine plus · 2020 · 2 citations
    16. The Use of Serenoa Repens (Saw Palmetto) in Hair Care Products Biomedical Journal of Scientific and Technical Research · 2019 · 2 citations
    17. Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system DOAJ (DOAJ: Directory of Open Access Journals) · 2016 · 2 citations
    18. Saw palmetto (Serenoa repens) in androgenic alopecia An effective phytotherapy 2003 · 2 citations
    19. What is the best treatment for androgenetic alopecia? Does the use of saw palmetto and African plum extracts help reduce hair loss? At what stage should medication be used, and when is a hair transplant recommended? Zenodo (CERN European Organization for Nuclear Research) · 2026
    20. What is the best treatment for androgenetic alopecia? Does the use of saw palmetto and African plum extracts help reduce hair loss? At what stage should medication be used, and when is a hair transplant recommended? Zenodo (CERN European Organization for Nuclear Research) · 2026
    21. The Safety and Efficacy of a Novel Saw Palmetto ( <i>Serenoa repens</i> ) Extract for Promoting Hair Growth in Adults With Self‐Perceived Thinning Hair: 180‐Day Results Journal of Cosmetic Dermatology · 2026
    22. Evaluation of the effectiveness of microneedle mesotherapy and supplementation with saw palmetto fruit extract in the treatment of female androgenetic alopecia. Case study Aesthetic Cosmetology and Medicine · 2026
    23. Botanical Synergies for Hair Health: A Review of Saw Palmetto and Urtica dioica in Non-Pharmaceutical Formulations 2026
    24. The Safety and Efficacy of a Proprietary Bioactive Fatty Acids Extract From Saw Palmetto ( <i>Serenoa repens</i> ) for Promoting Hair Growth and Reducing Hair Loss in Adults With Self‐Perceived Thinning Hair: 90‐Day Results Journal of Cosmetic Dermatology · 2025
    25. Nutritional Pharmacology and Mechanistic Insights of Saw Palmetto in Male Endocrine and Prostatic Disorders Zenodo (CERN European Organization for Nuclear Research) · 2025
    26. Nutritional Pharmacology and Mechanistic Insights of Saw Palmetto in Male Endocrine and Prostatic Disorders Zenodo (CERN European Organization for Nuclear Research) · 2025
    27. Hair Loss (Alopecia) Treatment using rosemary oil, peppermint oil, amla oil and saw palmetto: A students’ survey International journal of scholarly research in biology and pharmacy · 2024
    28. Oral and Topical Administration of a Standardized Saw Palmetto Oil Reduces Hair Fall and Improves the Hair Growth in Androgenetic Alopecia Subjects – A 16-Week Randomized, Placebo-Controlled Study Clinical, Cosmetic and Investigational Dermatology · 2023
    29. The role of 5-α-reductase inhibition in supressing progression of male androgenetic alopecia − a postulate for further studies on possible application of saw palmetto extracts Annales Academiae Medicae Silesiensis · 2023
    30. A Comparative Study of Topical Procapil With Platelet-Rich Plasma Therapy Versus Topical Redensyl, Saw Palmetto, and Biotin With Platelet-Rich Plasma Therapy in the Treatment of Androgenetic Alopecia. PubMed · 2023