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    Glossary Exosomes

    tiny vesicles that facilitate cell communication and material transport

    Exosomes are tiny, membrane-bound vesicles released by cells into the extracellular environment. They play a crucial role in cell-to-cell communication by transporting proteins, lipids, and genetic material between cells, which can influence various biological processes, including immune responses and tissue repair. In the context of hair and alopecia, exosomes are being studied for their potential to promote hair growth and regenerate hair follicles.

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    1. Human adipose-derived mesenchymal stem cells-derived exosomes encapsulated in pluronic F127 hydrogel promote wound healing and regeneration Stem Cell Research & Therapy · 2022 · 148 citations
    2. Exosomes for repair, regeneration and rejuvenation Expert Opinion on Biological Therapy · 2015 · 135 citations
    3. Human acellular amniotic membrane incorporating exosomes from adipose-derived mesenchymal stem cells promotes diabetic wound healing Stem Cell Research & Therapy · 2021 · 132 citations
    4. Regulation of hair follicle development by exosomes derived from dermal papilla cells Biochemical and Biophysical Research Communications · 2018 · 87 citations
    5. Exosomes and Their Bioengineering Strategies in the Cutaneous Wound Healing and Related Complications: Current Knowledge and Future Perspectives International Journal of Biological Sciences · 2023 · 72 citations
    6. Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling Science Advances · 2020 · 65 citations
    7. Exosomes derived from human dermal papilla cells promote hair growth in cultured human hair follicles and augment the hair‐inductive capacity of cultured dermal papilla spheres Experimental Dermatology · 2019 · 58 citations
    8. Exosomes mediate sensory hair cell protection in the inner ear Journal of Clinical Investigation · 2020 · 49 citations
    9. The novel mechanisms and applications of exosomes in dermatology and cutaneous medical aesthetics Pharmacological research · 2021 · 47 citations
    10. Plant-derived exosome-like nanovesicles: a novel therapeutic perspective for skin diseases Journal of Nanobiotechnology · 2025 · 46 citations
    11. Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata Frontiers in immunology · 2018 · 45 citations
    12. The Role of Exosomes Derived From Mesenchymal Stromal Cells in Dermatology Frontiers in Cell and Developmental Biology · 2021 · 44 citations
    13. Sustained Exosome‐Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and MiRNAs, and Sustained Release Formulation Small · 2022 · 40 citations
    14. MicroRNA-Enriched Exosomes from Different Sources of Mesenchymal Stem Cells Can Differentially Modulate Functions of Immune Cells and Neurogenesis Biomedicines · 2021 · 29 citations
    15. MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy Stem Cell Research & Therapy · 2021 · 25 citations
    16. Dendritic epidermal T cells secreting exosomes promote the proliferation of epidermal stem cells to enhance wound re-epithelialization Stem Cell Research & Therapy · 2022 · 24 citations
    17. 3D bioprinting of engineered exosomes secreted from M2-polarized macrophages through immunomodulatory biomaterial promotes in vivo wound healing and angiogenesis Bioactive Materials · 2024 · 22 citations
    18. Exosomes in Cosmetic Dermatology: A Review of Benefits and Challenges Journal of Drugs in Dermatology · 2024 · 18 citations
    19. Exosomes as a novel pathway for regulating development and diseases of the skin (Review) Biomedical Reports · 2018 · 15 citations
    20. Medicalized Aesthetic Uses of Exosomes and Cell Culture-Conditioned Media: Opening an Advanced Care Era for Biologically Inspired Cutaneous Prejuvenation and Rejuvenation Cosmetics · 2024 · 14 citations
    21. Promoting axonal regeneration through exosomes: An update of recent findings on exosomal PTEN and mTOR modifiers Brain Research Bulletin · 2018 · 14 citations
    22. Exploring the reality of exosomes in dermatology Anais Brasileiros de Dermatologia · 2024 · 13 citations
    23. Exosomes Derived From Human Adipose-Derived Stem Cells Inhibit Lipogenesis Involving Hedgehog Signaling Pathway Frontiers in Bioengineering and Biotechnology · 2021 · 13 citations
    24. Exploring the Potential of Mesenchymal Stem Cell–Derived Exosomes for the Treatment of Alopecia Regenerative Engineering and Translational Medicine · 2021 · 12 citations
    25. Exosome therapy in hair regeneration: A literature review of the evidence, challenges, and future opportunities Journal of cosmetic dermatology · 2022 · 12 citations
    26. Exosomes derived from umbilical cord mesenchymal stem cells promote healing of complex perianal fistulas in rats Stem Cell Research & Therapy · 2024 · 11 citations
    27. A comprehensive review of the medical and cosmetic applications of exosomes in dermatology Journal of Cosmetic Dermatology · 2024 · 10 citations
    28. Effects of exosome from adipose‐derived stem cell on hair loss: A retrospective analysis of 39 patients Journal of cosmetic dermatology · 2022 · 10 citations
    29. The therapeutic, diagnostic, and prognostic values of extracellular vesicles (exosomes) in dermatology: A systematic review JAAD reviews. · 2024 · 9 citations
    30. 17β-Estradiol Increases APE1/Ref-1 Secretion in Vascular Endothelial Cells and Ovariectomized Mice: Involvement of Calcium-Dependent Exosome Pathway Biomedicines · 2021 · 9 citations