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    Glossary Cepharanthine

    natural plant-derived compound with potential hair growth benefits

    Cepharanthine is a natural alkaloid derived from the plant Stephania cepharantha. It has been studied for its potential therapeutic effects, including anti-inflammatory, immunomodulatory, and anti-cancer properties. Recently, it has also shown promise in promoting hair growth and treating conditions like alopecia by improving blood circulation and inhibiting inflammatory responses in the scalp.

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    1. Cepharanthine: An update of its mode of action, pharmacological properties and medical applications Phytomedicine · 2019 · 125 citations
    2. Cepharanthine: a review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19 Pharmacological Reports · 2020 · 70 citations
    3. Cepharanthine loaded nanoparticles coated with macrophage membranes for lung inflammation therapy Drug Delivery · 2021 · 45 citations
    4. Cepharanthine, a regulator of keap1-Nrf2, inhibits gastric cancer growth through oxidative stress and energy metabolism pathway Cell Death Discovery · 2023 · 33 citations
    5. Cepharanthine Suppresses Herpes Simplex Virus Type 1 Replication Through the Downregulation of the PI3K/Akt and p38 MAPK Signaling Pathways Frontiers in Microbiology · 2021 · 30 citations
    6. Effects of cepharanthine and minoxidil on proliferation, differentiation and keratinization of cultured cells from the murine hair apparatus Archives of Dermatological Research · 1992 · 23 citations
    7. The common regulatory pathway of COVID-19 and multiple inflammatory diseases and the molecular mechanism of cepharanthine in the treatment of COVID-19 Frontiers in Pharmacology · 2022 · 15 citations
    8. Induction of insulin‐like growth factor‐I by cepharanthine from dermal papilla cells: A novel potential pathway for hair growth stimulation The Journal of Dermatology · 2013 · 13 citations
    9. The brief overview, antivirus and anti-SARS-CoV-2 activity, quantitative methods, and pharmacokinetics of cepharanthine: a potential small-molecule drug against COVID-19 Frontiers in Pharmacology · 2023 · 8 citations
    10. Cepharanthine induces the proliferation of human dermal papilla cells and stimulates vascular endothelial growth factor expression through increased intracellular calcium mobilization and hypoxia‐inducible factor activation Clinical and Experimental Dermatology · 2020 · 7 citations
    11. The Bis(1,2,3,4-tetrahydroisoquinoline) Alkaloids Cepharanthine and Berbamine Are Ligands of SK Channels ACS Medicinal Chemistry Letters · 2024 · 6 citations
    12. Cepharanthine attenuates pulmonary fibrosis via modulating macrophage M2 polarization BMC Pulmonary Medicine · 2024 · 6 citations
    13. Cepharanthine Dry Powder Inhaler for the Treatment of Acute Lung Injury Molecules · 2023 · 6 citations
    14. Cepharanthine: A review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19 2020 · 4 citations
    15. Cepharanthine, a regulator of keap1-Nrf2, inhibits gastric cancer growth through oxidative stress and energy metabolism pathway Research Square (Research Square) · 2023 · 4 citations
    16. Pharmacological Activity of Cepharanthine 2023 · 3 citations
    17. Cepharanthine inhibits enterovirus entry by endolysosomal deacidification and exhibits protective activity <i>in vivo</i> Antimicrobial Agents and Chemotherapy · 2025 · 2 citations
    18. Acceleration of Hair Growth Rate by Topical Liposomal Cepharanthine in Male Androgenetic Alopecia Hair therapy & transplantation · 2016 · 1 citations
    19. Anticancer activity of cepharanthine on non-small cell lung cancer cells 2020 · 1 citations
    20. Cepharanthine Inhibits Doxorubicin-Induced Cellular Senescence by Activating Autophagy via the mTOR Signaling Pathway Discovery medicine · 2023
    21. Cepharanthine inhibits tick‑borne encephalitis virus infection through modulation of the stress and inflammation response International Journal of Molecular Medicine · 2026
    22. Anticancer Effects of Cepharanthine: an Updated Minireview Journal of Cancer · 2026
    23. Evaluating cepharanthine analogues as natural drugs against SARS‐CoV‐2 FEBS Open Bio · 2021 · 29 citations
    24. Evaluating cepharanthine analogues as natural drugs against SARS-CoV-2 2021
    25. Bioavailability Enhancement of Cepharanthine via Pulmonary Administration in Rats and Its Therapeutic Potential for Pulmonary Fibrosis Associated with COVID-19 Infection Molecules · 2022 · 14 citations
    26. Lung-Targeted Delivery of Cepharanthine by an Erythrocyte-Anchoring Strategy for the Treatment of Acute Lung Injury Pharmaceutics · 2022 · 8 citations
    27. Unraveling the mechanism of action of cepharanthine for the treatment of novel coronavirus pneumonia (COVID-19) from the perspectives of systematic pharmacology Arabian Journal of Chemistry · 2023 · 7 citations
    28. Protective Role of Cepharanthine Against Equid Herpesvirus Type 8 Through AMPK and Nrf2/HO-1 Pathway Activation Viruses · 2024 · 3 citations
    29. Efficient Inhibition of Endometriosis Growth by Cepharanthine In Vitro, in Patient-Derived Endometrial Organoids, and In Vivo Clinical and Experimental Obstetrics & Gynecology · 2026
    30. Effects of cepharanthin and minoxidil on growth and differentiation of the cultured hair and hair follicle cells; An electron microscopic analysis Journal of Dermatological Science · 1990