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The NUDT15 R139C variant causes thiopurine-induced leukocytopenia through a different mechanism than previously thought in Japanese patients with inflammatory bowel disease.

Thiopurines help treat IBD but require genetic testing to avoid side effects.

AHCC reduces hair loss and liver injury caused by chemotherapy in rodents.

Elental is a good long-term treatment for Crohn's disease, similar to 6-mercaptopurine but with fewer side effects.

Azathioprine may help treat severe alopecia areata, but more research is needed.

The NUDT15 gene variant causes severe side effects from azathioprine in some Indian patients.

Azathioprine's effectiveness and safety require careful monitoring and more research, especially regarding its use with corticosteroids and the role of TPMT status in patients.

The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.

Genotyping for NUDT15 p.Arg139Cys can help predict thiopurine side effects in Japanese IBD patients.

The pseudo 'fringe sign' can also appear in frontal fibrosing alopecia, not just in traction alopecia, showing that this condition may be more common than thought.

A man with multiple autoimmune diseases developed liver injury from azathioprine, but his liver improved after stopping the drug.

Genetic screening for NUDT15 polymorphisms is crucial for patients taking azathioprine, especially in Asians.

Azathioprine caused side effects in over half of the Korean pediatric inflammatory bowel disease patients, requiring close monitoring.

Monitor for early signs of azathioprine toxicity and check blood counts regularly.

Immunosuppressive and anti-TNF therapies in IBD patients can increase the risk of skin cancer and cause various skin issues.

New psoriasis treatments are effective but come with side effects and risks.

Understanding drug interactions, side effects, and patient-specific factors is crucial for effective dermatological care.

Non-biologic immunosuppressive drugs are crucial for treating autoimmune and chronic inflammatory skin diseases.

Researchers found that most genes affecting drug responses are not fully covered by commercial SNP chips, suggesting the need for more comprehensive tools to optimize drug selection based on genetics.

The document explains how the immune system reacts to organ transplants and the treatments used to prevent rejection.

The conclusion is that effective cancer treatment often requires a combination of therapies, but must be carefully managed due to serious side effects and the risk of immunosuppression.

Mitoxantrone is effective for treating acute leukemia, especially in older patients, with a lower risk of heart damage.

Proper skin toxicity management in chemotherapy is key to continuing treatment and keeping patient quality of life high.

Azathioprine can cause severe blood issues and hair loss, needing careful monitoring and possible discontinuation.

Chemotherapy can cause various skin reactions, with hair loss being the most common, and proper diagnosis and treatment of these reactions are important.

Finasteride is effective for male hair loss, teledermatology is accurate and accepted, and cyclosporin helps treat toxic epidermal necrolysis.

Mycophenolate mofetil can effectively treat autoimmune hepatitis when standard drugs fail.

Some dermatological medications can impair male fertility, so consult a doctor before trying to conceive.

Hair loss in cancer patients can be related to the cancer itself, treatment, or other conditions, and understanding it is important for diagnosis and patient care.

Scalp cooling is the most effective FDA-approved method to prevent chemotherapy-induced hair loss, but more research is needed for other treatments.