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The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

Scientists found new, better-working inhibitors for a hormone-related enzyme.

New compounds can block testosterone effects in rats and might help treat conditions like prostate cancer and acne.

Stopping the use of fluocinolone oil containing balsam fragrance improved hair regrowth in children allergic to it.

Sophora flavescens extract helps hair growth and treats hair loss.

Flumethasone causes wool shedding in Merino wethers, with recovery in about 60 days.

Compound 15a was effective in inhibiting 5α-reductase.

Some skin medications are safe for pregnant women, but others pose risks or should not be used.

Crescina® lotion helps reduce hair loss and increase hair growth in males with androgenetic alopecia.

Testosterone affects blood pressure control and inflammation in male rats with endotoxic shock, and blocking certain hormones may help treat it.

Minoxidil does not work to inhibit lysyl hydroxylases in newborn mouse lungs.

Alopecia in dogs is often caused by mange, flea and tick infestations, and nutritional deficiencies, especially in males and young dogs.

Targeting NETs may help reduce fibrosis in Crohn's disease.

The document reviews key historical figures and discoveries in dermatology.

Experts discussed treatments for skin conditions in children, emphasizing hydration, cautious medication use, and early intervention for infections.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

Researchers created human hair follicles using a new method that could help treat hair loss.

No single treatment is consistently effective for alopecia areata, and more research is needed.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Most dermatologic medications are safe during pregnancy and breastfeeding, but some should be avoided due to potential risks.

Avoiding certain nutrients and drugs may help manage pemphigus.

New compounds with carborane showed anti-androgen effects similar to flutamide.

Group a wide range of chemicals, not just phthalates, for assessing risks to male reproductive health.

Dermatologists need to know about cosmetics to help patients with skin issues and recommend safe products.

Deoxycholic acid is effective for reducing chin fat but can cause side effects and serious complications, so careful patient evaluation is needed.

The new FDA labeling rules provide more detailed drug safety information for pregnant and breastfeeding women, but more data is needed on the risks of many dermatologic drugs.

Certain extracts from Curcuma aeruginosa Roxb. and germacrone can boost the skin's absorption of minoxidil, a hair growth promoter, making it more effective.

Lepidium sativum seed extracts helped reduce inflammation and improve insulin response in obese rats on a high-fat diet.

Created large amounts of grape seed compounds using a new method.