research 5α-Reductase Inhibitors
Finasteride effectively treats enlarged prostate and male baldness, improves symptoms of hirsutism in women, but doesn't work for acne, and may delay prostate cancer progression with few side effects.
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research Enhanced Skin Permeation of 5α-Reductase Inhibitors Entrapped into Surface-Modified Liquid Crystalline Nanoparticles
Special nanoparticles increased skin absorption of hair loss treatments with fewer side effects.
research Saturable Binding of Finasteride to Steroid 5α-Reductase as Determinant of Nonlinear Pharmacokinetics
Finasteride's effect on hair loss and prostate enlargement depends on its binding to an enzyme, with maximum impact at 0.2 mg dose.
research Spectrofluorimetric Study of Finasteride and Bovine Serum Albumin Interaction and Its Application for Quantitative Determination of Finasteride in Tablet Dosage Form
Method accurately measures finasteride in tablets using finasteride-BSA interaction.
research Hirsutism II: Treatment
The document concludes that various cosmetic and drug treatments are available for hirsutism, and some new drugs show promise.
research In Vivo Investigation in Pigs of Intestinal Absorption, Hepatobiliary Disposition, and Metabolism of the 5α-Reductase Inhibitor Finasteride and the Effects of Coadministered Ketoconazole
Ketoconazole increases finasteride's effectiveness and lifespan in the body.
research The Feminism and Psychology Undergraduate Prize 1999: Prizewinning Entry
The entry showed that PCOS negatively affects women's self-image and is worsened by societal expectations, suggesting a need for more feminist attention to the condition.
research Is The Metabolism Of Testosterone To 5α-Dihydrotestosterone Required For Androgen Action In The Skin?
Testosterone conversion to 5α-DHT may not be essential for its effects on the skin.
research An Asian Traditional Herbal Complex Containing Houttuynia Cordata Thunb, Perilla Frutescens Var. Acuta, and Green Tea Stimulates Hair Growth in Mice
The Asian herbal mix with Houttuynia cordata, Perilla frutescens, and green tea helped grow hair in mice.
research Finasteride and Male Breast Cancer: Does the MHRA Report Show a Link?
No definitive link between finasteride and male breast cancer, but further research is needed.
research Chemical Mechanism of the Covalent Modification of 5-Alpha-Reductases by Finasteride as Probed by Secondary Tritium Isotope Effects
Finasteride modifies 5-alpha-reductases through a two-step process, affecting inhibitor potency and possibly causing side effects.
research Vascular Endothelial Growth Factor Protects CD200-Rich and CD34-Positive Hair Follicle Stem Cells Against Androgen-Induced Apoptosis Through the Phosphoinositide 3-Kinase/Akt Pathway in Patients With Androgenic Alopecia
A substance called Vascular Endothelial Growth Factor can protect certain hair follicle stem cells from damage caused by androgens, suggesting a new possible treatment for hair loss.
research Metabolic Dysfunction in Female Mice with Disruption of 5α-Reductase 1
Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.
research The Long-Term Effect of Specific Type II 5α-Reductase Inhibition With Finasteride on Bone Mineral Density in Men: Results of a 4-Year Placebo-Controlled Trial
Finasteride doesn't harm bone density in older men with BPH.
research 11α-Hydroxyprogesterone, a Potent 11β-Hydroxysteroid Dehydrogenase Inhibitor, Is Metabolized by Steroid-5α-Reductase and Cytochrome P450 17α-Hydroxylase/17,20-Lyase to Produce C11α-Derivatives of 21-Deoxycortisol and 11-Hydroxyandrostenedione In Vitro
11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.
research Case-Only Trees and Random Forests for Exploring Genotype-Specific Treatment Effects in Randomized Clinical Trials with Dichotomous End Points
Case-only trees and random forests improve predictions of treatment effects in clinical trials.
research Three-Dimensional Proteome-Wide Scale Screening for the 5-Alpha Reductase Inhibitor Finasteride: Identification of a Novel Off-Target
Finasteride may affect PNMT, causing side effects.
research The 5α-Reductase Inhibitor Finasteride Is Not Associated With Alterations in Sleep Spindles in Men Referred for Polysomnography
Finasteride doesn't affect sleep spindles in men.
research Effect of the Dual 5α-Reductase Inhibitor Dutasteride on Markers of Tumor Regression in Prostate Cancer
Dutasteride may help shrink prostate cancer tumors.
research Letter to the Editor: Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss
Finasteride use may cause sexual dysfunction; more research needed.
research Effects of Solvent System and Storage Condition on Chemical Stability of 5α-Reductase Inhibitor Compounds in Tectona Grandis Leaf Extracts
Store Tectona grandis leaf extracts in slightly acidic, light-protected conditions for best stability.
research Analysis of the Relationship Between Hypertension and Diabetes Mellitus in Androgenic Alopecia at the Faculty of Medicine, Universitas Muslim Indonesia, Ibnu Sina Hospital, and UMI Tower Makassar
There is a significant relationship between androgenic alopecia, hypertension, and diabetes mellitus.
research Regenerative Medicine Approaches for Engineering a Human Hair Follicle
New treatments for hair loss show promise, including plasma, stem cells, and hair-stimulating complexes, but more research is needed to fully understand them.
research Androgen Biosynthesis and Gene Defects
Gene mutations can cause problems in male genital development.
research Topical Minoxidil Fortified with Finasteride: Maintenance of Hair Density After Replacing Oral Finasteride
Using minoxidil with finasteride in a cream helps maintain hair thickness after stopping oral finasteride.
research Review: Dutasteride, Fesoterodine, and Finasteride Are Beneficial for Lower Urinary Tract Symptoms in Older Patients
Dutasteride, fesoterodine, and finasteride help older patients with urinary issues.
research 5α-Reductase Inhibitors in the Treatment of Androgenetic Alopecia
Finasteride improves hair growth in men with androgenetic alopecia.
research Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells
Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
research Androgens and Cardiovascular Disease
Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.
research Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline
More dermal papilla cells in hair follicles lead to larger, healthier hair, while fewer cells cause hair thinning and loss.