26 citations,
September 2012 in “Epilepsy & Behavior” Finasteride worsens seizures in epilepsy rats and speeds up epileptogenesis in mice.
25 citations,
March 2017 in “Steroids” Allopregnanolone increases growth and changes gene activity in human brain cancer cells.
25 citations,
November 2001 in “Kidney International” Male hormones worsen kidney transplant damage, but blocking them helps.
24 citations,
October 1994 in “Fertility and Sterility” People with hair loss may have different levels of certain hormones due to changes in hormone processing.
21 citations,
January 2003 in “Skin pharmacology and physiology” Different skin cells process testosterone differently, and certain drugs can change this process, possibly helping treat acne and hair loss.
20 citations,
August 2019 in “Expert Opinion on Drug Safety” Some medications for bladder problems can cause memory issues or mood changes, and doctors should monitor these side effects.
20 citations,
April 2006 in “Dermatologic Clinics” Antiandrogen therapies are beneficial for treating skin and hair conditions related to androgen levels.
19 citations,
January 2016 in “Biological & Pharmaceutical Bulletin” Sargassum muticum extract and its component apo-9'-fucoxanthinone may help hair growth and treat hair loss.
17 citations,
May 2019 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” AKR1D1 controls glucocorticoid levels and receptor activity in liver cells.
15 citations,
November 2003 in “Dermatologic Surgery” Minoxidil, finasteride, and hair transplantation combined give best results for hair loss.
14 citations,
December 1998 in “The Journal of Clinical Endocrinology and Metabolism” MENT could be a better option than testosterone for male hormone therapy and birth control because it works well at lower doses and has fewer side effects on the prostate.
13 citations,
October 2002 in “Journal of Biochemical and Biophysical Methods” Men with male-pattern baldness have higher levels of certain testosterone metabolites and may have more active androgen metabolism.
11 citations,
September 2020 in “OncoTargets and Therapy” Dihydrotestosterone increases growth and spread of human brain cancer cells, and blocking its formation might help treat this cancer.
11 citations,
August 2020 in “Diabetes” Testosterone helps human pancreatic cells increase insulin release.
11 citations,
January 2001 in “Cambridge University Press eBooks” Androgens can cause hair growth in some areas but hair loss on the scalp.
10 citations,
October 2008 in “Andrologia” Finasteride changes antioxidant enzyme expression, possibly affecting sperm protection in rats.
9 citations,
September 2009 in “The Prostate” Finasteride doesn't improve survival in LNCaP tumor model during off-cycle of therapy.
6 citations,
January 2020 in “BMC Neuroscience” Male tissue has more cell death than female tissue after ischemia, and some neurosteroids only protect female cells.
6 citations,
January 2016 in “Evidence-based complementary and alternative medicine” Saw palmetto supplements may reduce prostate cancer cell growth without being toxic.
6 citations,
January 2008 in “Medical Hypotheses” Male pattern baldness might have evolved to help protect against prostate cancer by increasing UV radiation on the scalp.
4 citations,
January 2020 in “General and Comparative Endocrinology” Male yak hair growth is influenced by DHT synthesis, which is promoted by 5α-red1 and AR during growth phases, while E2 may inhibit growth through ERα.
4 citations,
December 2015 in “Journal of Medicinal Plants Research” A plant mixture extract helped grow hair by boosting cell growth and growth factors while blocking a hair loss-related enzyme.
4 citations,
April 1999 in “Dermatologic Clinics” Androgens, like DHT, affect hair growth and treatments like finasteride may help.
4 citations,
October 1988 in “Clinics in Dermatology” Dihydrotestosterone (DHT) is crucial for conditions like male-pattern baldness and acne, and measuring a byproduct, androstanediol glucuronide, is a better way to assess DHT's effects than DHT blood levels.
3 citations,
July 2021 in “Dermatologic Clinics” The document concludes that more research is needed to understand hair loss in men and to find new treatments.
3 citations,
January 2017 in “Journal of cosmetology & trichology” The nutritional supplement improved hair quality and reduced hair loss.
2 citations,
September 2020 in “Behavioural Brain Research” Changing neuroactive steroids in baby male rats affects their memory and learning differently as they grow up.
2 citations,
January 2007 in “Journal of Labelled Compounds and Radiopharmaceuticals” The conclusion is that tritium-labeled testosterone metabolites can be made and are better converted into dihydrotestosterone in skin cells than in prostate tissue.
2 citations,
January 2007 in “Lancet Oncology” Finasteride significantly reduces PSA levels in men, and doctors should adjust PSA readings for those taking the drug.
1 citations,
July 2022 in “Han'gug sigpum yeong'yang gwahag hoeji/Journal of the Korean society of food science and nutrition” Eurycoma longifolia extract may help increase testosterone levels and reduce andropause symptoms.