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Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

PNU157706 reduced rat sperm movement and fertility without affecting offspring health.

Certain compounds, especially those with a propionic substituent, could potentially be new treatments for hair loss and similar disorders.

5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.

Compounds from the plant Mammea siamensis may help treat hair loss.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Certain Chinese herbs, especially Cacumen platycladi, can promote hair regrowth and reduce hair loss-related hormone levels in mice.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

High-dose dutasteride reduces PMDD symptoms by stabilizing neurosteroid levels.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Four-amino acid part makes enzyme sensitive to finasteride.

Dutasteride works better than finasteride for hair loss, with both being safe to use.

The document concludes that the risk of sexual side effects from 5-alpha-reductase inhibitors is low and often temporary, but more research is needed on potential permanent effects.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Finasteride and dutasteride effectively treat hair loss in men and women, but may cause side effects like low libido and depression.

5α reductase inhibitors treat hair loss but may cause sexual side effects and risks.

Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.

Finasteride doesn't affect ovulation in normal women.

Hormonal treatments can help with acne, especially in women, by lowering androgen levels or blocking their effects.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

New treatments for enlarged prostate are being developed to be more effective and have fewer side effects.

Cuscuta reflexa extracts and an isolate promoted hair growth and could be natural treatments for hair loss.

The document concludes that combination therapy is most effective for treating excessive hair growth in women with idiopathic hirsutism, and more research is needed to understand the condition.

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

The document concludes that more research is needed to understand excessive hair growth in women with normal hormone levels and regular ovulation.