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Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.

The document concludes that the risk of sexual side effects from 5-alpha-reductase inhibitors is low and often temporary, but more research is needed on potential permanent effects.

The conclusion is that doctors should be careful when prescribing 5α-reductase inhibitors due to possible serious side effects, and they should discuss these risks with patients.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

Dutasteride is more efficient than finasteride, but individual results vary.

New compounds were made that effectively block enzymes related to prostate issues and hair loss.

Steroids, particularly estrogens and 5α-reductase inhibitors, affect blood vessel-related hair growth processes in hair follicle cells.

PNU157706 reduced rat sperm movement and fertility without affecting offspring health.

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.

Eclipta alba extract could be a promising natural treatment for hair loss.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Phosphodiesterase inhibitors like tadalafil can reduce cell growth in BPH caused by CD8+ T cells in low androgen conditions.

Dihydrotestosterone and 5α-Reductase play a role in hair loss and prostate health, and finasteride can increase hair growth in men without affecting sperm production, but it doesn't work for postmenopausal women with hair loss.

Lygodii Spora extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.

Some breast cancer patients on hormone therapy experience hair loss, and treatments like certain topical inhibitors and supplements may help without harming their cancer prognosis.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

Hormonal treatments can help with acne, especially in women, by lowering androgen levels or blocking their effects.

Some common medications can harm male fertility, but many effects can be reversed.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Testosterone and dihydrotestosterone play a role in women's health issues like excess hair and baldness, and treatments blocking these hormones may help.

Finasteride may cause lasting sexual, mental, and physical symptoms; use with caution.

New treatments for enlarged prostate are being developed to be more effective and have fewer side effects.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

Plant extracts may help treat hormone-related hair loss.

The drugs finasteride and dutasteride reduce low-grade prostate cancers but may double the risk of high-grade cancers.

The document concludes that individualized treatments for hair issues are effective, certain hair changes can indicate neurocutaneous diseases, specific lotions improve skin health, laser hair removal works but needs more study on long-term effects, men's cosmetics are diverse, peeling is effective but can have side effects, and facial pigmentation is often due to overactive skin cells.

Some herbs and their components might help treat hair loss by affecting various biological pathways, but more research and regulation are needed.

The document concludes that more research is needed to understand excessive hair growth in women with normal hormone levels and regular ovulation.

Some hormone-related drugs may protect brain cells in Parkinson's disease differently in men and women.