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The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

High-dose dutasteride reduces PMDD symptoms by stabilizing neurosteroid levels.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

Steroids, particularly estrogens and 5α-reductase inhibitors, affect blood vessel-related hair growth processes in hair follicle cells.

Women with female-pattern baldness produce more testosterone, but 5a-reductase inhibition treatment won't help.

Finasteride doesn't affect oral testosterone undecanoate, and high DHT levels may cause acne, prostate issues, and hair loss.

The higher dose supplement was more effective in treating female hair loss.

The document concludes that the risk of sexual side effects from 5-alpha-reductase inhibitors is low and often temporary, but more research is needed on potential permanent effects.

The conclusion is that doctors should be careful when prescribing 5α-reductase inhibitors due to possible serious side effects, and they should discuss these risks with patients.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

Dutasteride is more efficient than finasteride, but individual results vary.

New compounds were made that effectively block enzymes related to prostate issues and hair loss.

The study found that two enzymes linked to hair loss are located in different parts of the scalp, supporting a common treatment's effectiveness.

An extract from Quercus acutissima bark was found to reduce sebum production and block an enzyme linked to acne.

Finasteride doesn't harm bone density in older men with BPH.

Inhibiting 5α-reductase increases progesterone levels in late pregnant mares.

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.

Some Thai plants, especially Carthamus tinctorius, could help prevent hair loss and promote hair growth without adverse effects.

Certain natural compounds can block an enzyme linked to prostate enlargement and hair loss, showing potential for new treatments.

Eclipta alba extract could be a promising natural treatment for hair loss.

Ginseng, especially red ginseng, may help regrow hair and block a hair loss-related enzyme.

Blocking 5α-reductase can harm memory and brain structure, and increase harmful brain changes in male mice used for Alzheimer's disease research.

Two types of 5α-reductase are in dog skin, which might make dutasteride better than finasteride for treating dog hair loss.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Phosphodiesterase inhibitors like tadalafil can reduce cell growth in BPH caused by CD8+ T cells in low androgen conditions.

Dihydrotestosterone and 5α-Reductase play a role in hair loss and prostate health, and finasteride can increase hair growth in men without affecting sperm production, but it doesn't work for postmenopausal women with hair loss.

Lygodii Spora extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.

Some breast cancer patients on hormone therapy experience hair loss, and treatments like certain topical inhibitors and supplements may help without harming their cancer prognosis.

Men with early balding showed higher levels of certain genes linked to hair loss and possibly prostate cancer.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.