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Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.

Finasteride exposure in pregnancy causes genital abnormalities in male rats.

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

Men taking dutasteride or finasteride have a slightly higher risk of developing type 2 diabetes.

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

Finasteride safely lowers DHT levels without affecting testosterone.

The study found that two enzymes linked to hair loss are located in different parts of the scalp, supporting a common treatment's effectiveness.

Finasteride doesn't affect hormone levels in normal men.

Finasteride lowers DHT levels and raises testosterone in a dose-dependent way.

The document concludes that the risk of sexual side effects from 5-alpha-reductase inhibitors is low and often temporary, but more research is needed on potential permanent effects.

Androgens, like testosterone, are crucial for early testicular descent in rats.

Androgen conjugates might be better indicators of skin sensitivity to hormones in women with excessive hair growth.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

Finasteride reduces hair growth and is safe for women with excessive hair.

Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.

Finasteride effectively treats enlarged prostate and male baldness, improves symptoms of hirsutism in women, but doesn't work for acne, and may delay prostate cancer progression with few side effects.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Flutamide may slightly improve hair loss in women, but finasteride does not work.

Ganoderma lucidum, a type of mushroom, may help treat enlarged prostate by blocking testosterone conversion.

Diet changes can help reduce acne by limiting certain hormones.

Finasteride may increase erectile dysfunction risk in patients with benign prostatic hyperplasia.

Women with hair loss had higher levels of certain hormones, suggesting a link to a condition like PCOS.

Certain drugs change freshwater snail shells to a "banana" shape.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

Proscar (finasteride) blocks 5α-reductase in sea urchin ovaries and testes, suggesting potential treatment for androgen-related conditions.

Current research explores hair growth drugs, while future research aims for personalized treatments.

5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.

Pomegranate peel compounds may help treat hair loss.