22 citations
,
April 2012 in “The American journal of pathology” This study found that the loss of Msx2 in knockout mice led to phenotypes similar to Peters anomaly and microphthalmia, suggesting that MSX2 plays a critical role in anterior segment development of the eye.
21 citations
,
March 2022 in “Pharmaceuticals” This study found that Brigatinib-loaded nanospanlastics demonstrated enhanced cytotoxicity against lung cancer cells and improved drug stability and release compared to free Brigatinib.
21 citations
,
April 2021 in “ACS omega” In this study, curcumin was efficiently loaded into PS–PAA nanoparticles at the formation stage, showing even distribution at low concentrations and good biocompatibility with human skin fibroblasts.
19 citations
,
December 2012 in “BMC Complementary and Alternative Medicine” This study demonstrates that young coconut juice appears to have estrogen-like properties that can accelerate wound healing in ovariectomized rats.
9 citations
,
July 2024 in “JAAD reviews.” This review discusses the role of extracellular vesicles in dermatology for therapeutic, diagnostic, and prognostic purposes, highlighting the lack of validated findings and the necessity for more rigorous clinical trials.
7 citations
,
January 2011 in “Biochemistry Research International” This study confirms that the proposed universal model for hard α-keratin structure applies to all known forms across various mammalian species.
4 citations
,
May 2025 in “Stem Cell Research & Therapy” This review explores the potential of extracellular vesicle therapy as a novel strategy to delay intervertebral disc degeneration and enhance tissue repair, by modulating key pathogenic mechanisms, with a focus on the molecular components and bioengineering modifications of extracellular vesicles.
4 citations
,
January 2023 in “Marine Drugs” This review explores enzyme inhibitors from gorgonians and soft corals and highlights their potential industrial and biomedical applications, but it reports no new experimental results.
3 citations
,
August 2023 in “Biophysical Journal” In this study, researchers found that epithelial cells exhibit density-dependent metabolic heterogeneity, particularly in the pre-epithelial transition stage, where metabolic patterns correlate with cell proliferation and are influenced by actomyosin contractility.
3 citations
,
March 2021 in “Clinical, Cosmetic and Investigational Dermatology” This study reviews the types of alopecia associated with lupus erythematosus and discusses treatment challenges, highlighting that non-scarring alopecia is specific to systemic lupus while chronic cutaneous lupus can cause scarring alopecia, with topical corticosteroids and oral antimalarials as primary treatments for cutaneous lupus erythematosus.
2 citations
,
October 2023 in “Science advances” In this study, researchers demonstrated that human hair follicle outer root sheath cells release ATP, serotonin, and histamine in response to mechanical stimulation, which subsequently activates surrounding sensory neurons.
February 2025 in “BMC Genomics” This study found that in cashmere goats, melatonin treatments enhanced cashmere growth by stimulating secondary hair follicles, increasing follicle density, and improving yield and quality, highlighting key genes and metabolic pathways involved in this process.
January 2025 in “Dermatologic Therapy” This study found that ablative fractional carbon dioxide laser treatment improved skin fibrosis, reduced skin hardening, and enhanced hair follicle growth in localized scleroderma patients, with significant improvements across several clinical measures and no severe adverse effects observed.
12 citations
,
December 2015 in “F1000Research” This article discusses advancements and future directions in the treatment of benign prostatic hyperplasia, highlighting ongoing clinical trials of novel techniques, but it reports no new clinical results.
This review compiles existing information on the pathogenesis of androgenetic alopecia, highlighting its genetic, hormonal, and environmental factors, but reports no new clinical findings.
January 2015 in “Faculty of 1000 Research Ltd” BPH treatment improved with personalized medicine, new drugs, and less invasive surgeries.
43 citations
,
May 1999 in “Journal of Biological Chemistry” This study found that full-length Agouti protein modulates melanocortin receptor signaling through a dual mechanism involving competitive antagonism and receptor down-regulation, whereas the carboxyl-terminal fragment acts solely as a competitive antagonist.
15 citations
,
June 2019 in “eLife” This study identified Activin A and follistatin as key regulators of hair cell differentiation in the mammalian auditory sensory epithelium, with Activin A signaling influencing the timing and pattern of cell differentiation.
This study identified Activin A and its antagonist follistatin as crucial regulators of hair cell differentiation in mice, suggesting a local gradient of Activin A influences auditory sensory epithelium development.
This study identifies Activin A and follistatin as key regulators of hair cell differentiation in the mouse auditory sensory epithelium, influencing the timing and pattern of hair cell development.
665 citations
,
April 2016 in “Nature communications” This study shows that inhibiting anti-apoptotic proteins BCL-W and BCL-XL can specifically induce apoptosis in senescent cells, suggesting a potential strategy for treating age-related pathologies.
214 citations
,
April 2017 in “Cell” This study found that micro-niches within hair follicles create heterogeneity among stem cells and transit-amplifying cells, leading to specialized progenitors that control tissue morphogenesis and regeneration.
209 citations
,
October 2018 in “Cell Reports” This study found that Lgr5 and Lgr6 stem cells both activated wound-healing genes, but only Lgr5 stem cells changed their identity to contribute to new skin formation during wound repair.
195 citations
,
December 2009 in “Journal of Investigative Dermatology” This study found that sebum free fatty acids may enhance the antibacterial defense of human sebaceous glands by upregulating the expression of the antimicrobial peptide hBD-2, potentially aiding in acne treatment.
176 citations
,
January 2013 in “Proceedings of the National Academy of Sciences” This study reveals an antagonistic competition between BMP and Wnt signaling within stem cells, influencing their fate towards hair germ characteristics based on the BMP/Wnt activity ratio.
173 citations
,
August 2015 in “Developmental cell” This study characterizes gene expression patterns in embryonic hair follicle progenitors and their niche, identifying signaling pathways like axon guidance that may drive cellular rearrangements for hair follicle formation.
169 citations
,
February 2018 in “Immunity” In this study, researchers found that quiescent stem cells resist immune attack due to downregulated antigen presentation, which may help explain the immune evasion of early cancer-initiating cells.
151 citations
,
August 2011 in “The EMBO Journal” The enzyme PA-PLA1α is important for proper hair follicle development.
129 citations
,
October 2017 in “BMC Genomics” This study identified potential ceRNA regulatory networks in cashmere goat hair follicle cycling, expanding understanding of lncRNA and miRNA biology and annotation of the goat genome.
125 citations
,
February 2007 in “The EMBO Journal” Fgfr2b helps maintain healthy skin and prevent cancer.