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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.

Testosterone helps human pancreatic cells increase insulin release.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

A new plant extract from Avicennia marina could potentially be used to treat common hair loss.

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

Some hair loss and prostate drugs might increase the risk of diabetes and heart disease.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

Finasteride and spironolactone both reduce hirsutism, but finasteride lowers androgen levels more.

Finasteride negatively affects fish reproduction and gonadal development.

Finasteride may increase erectile dysfunction risk in patients with benign prostatic hyperplasia.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Finasteride is a safe, effective treatment for hirsutism with fewer side effects.

5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

Testosterone may slow down wound healing and increase inflammation.

The herbal extract was found to effectively reduce and prevent hair loss without any side effects.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

DHT's role in hair loss is important, but measuring its level for diagnosis is questionable.

Antiandrogens are the main treatment for hirsutism, with individualized care and safe, affordable options needed.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

DHT, a testosterone byproduct, causes male pattern baldness.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Finasteride effectively reduces hair loss by decreasing androgen levels.

Finasteride, a drug used for certain conditions, can cause serious side effects like sexual dysfunction, suicidal thoughts, and increased diabetes risk, and there's a need for more awareness and research about these effects.

5α-Reductase inhibitors can help treat hair loss, acne, and prostate issues by reducing DHT levels.