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Reduced androgens linked to kinky hair disorder and hair loss; 5a-reductase inhibitors may help.

New compounds may help treat prostate cancer by reducing cell growth.

Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

A new plant extract from Avicennia marina could potentially be used to treat common hair loss.

High levels of testosterone and 5α-DHT can lead to cell death in cells important for hair growth.

Testosterone conversion to 5α-DHT may not be essential for its effects on the skin.

Minocycline may cause hair loss by increasing DHT levels, but finasteride can help counteract this effect.

Finasteride affects frog testes by increasing testosterone, decreasing 5α-DHT, and impacting genes related to reproduction and other functions.

Mice with human gene experienced hair loss when treated with DHT.

Rat skin takes up and processes testosterone differently than other organs, with testosterone being more important for the skin than its metabolite 5α-DHT.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Finasteride affects prostate weights and pituitary activity differently with age.

Avicequinone C, a compound found in the Avicennia marina plant, can reduce hair loss by inhibiting a hormone linked to androgenic alopecia.

Green tea component EGCG may help prevent hair loss by changing microRNA levels in certain scalp cells.

Many treatments for hair loss lack proper testing and FDA approval, so their effectiveness is uncertain.

Finasteride works better for hair loss in patients 26 or younger.

AGA is a genetic, hormonal hair loss treated with finasteride, minoxidil, and supplements, but new compounds are being developed.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Treatment during development affects hormone balance and sexual behavior in male rats.

New steroids were effective in blocking male hormone receptors in hamster prostates.

The effects of estrogen on human scalp hair growth are unclear and need more research.

Male rats have androgen receptors in their liver, which are different from proteins that bind estrogen.

New pregnane derivatives were more effective than finasteride at inhibiting a key enzyme for male pattern baldness.

TR3 is mainly found in hair follicle stem cells and may be involved in hair loss.

Testosterone is crucial for development, growth, and various body functions in mammals.

Saw palmetto is an effective natural treatment for hair loss with minimal side effects.

Male hormones affect oil-producing skin cells differently based on their body location, and the drug spironolactone can reduce these effects.

Blocking the androgen receptor in skin cells reduces their growth response to male hormones, suggesting a possible treatment for skin conditions linked to androgens.