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The document concludes that the risk of sexual side effects from 5-alpha-reductase inhibitors is low and often temporary, but more research is needed on potential permanent effects.

Finasteride, a drug used for certain conditions, can cause serious side effects like sexual dysfunction, suicidal thoughts, and increased diabetes risk, and there's a need for more awareness and research about these effects.

Endocrine disruptors may cause early hair loss.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Finasteride effectively treats BPH, but needs more trials to understand potential.

Most women with excess hair growth have an underlying hormonal issue, often treated with medication and hair removal methods.

Metformin is effective for treating excessive hair growth in women with PCOS and may work better than the standard treatment in some ways.

Finasteride for hair loss can cause long-lasting sexual side effects like low libido and erectile dysfunction.

Lower doses of treatments for hirsutism and acne in PCOS are effective and cause fewer side effects.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Certain genetic variations in the AR and ERβ genes can affect androgen levels in women.

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

DHEA stimulates skin oil glands and could help postmenopausal women, with potential for acne and excessive hair growth treatments.

New treatments for male hypogonadism are effective and should be personalized.

Hormonal treatments can help with acne but are not the first choice due to side effects and the need for careful patient selection.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Finasteride is a safe, effective treatment for hirsutism with fewer side effects.

The document concludes that early recognition and treatment of PCOS in adolescents is crucial for managing symptoms and long-term health risks.

Finasteride can slow hair loss and promote growth in postmenopausal women.

Androgens can both promote and prevent hair growth due to differences in gene expression in hair follicles.

Finasteride affects brain and blood steroids, causing lasting sexual and emotional side effects.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

Minoxidil helps grow longer, thicker hair in bald scalps of stumptailed macaques, and early treatment is more effective.

Genes and hormones cause hair loss, with four genes contributing equally.

Diane 35 plus finasteride is more effective in reducing hair growth and androgen levels, but may decrease libido.

Androgens may influence T cells, contributing to higher autoimmune liver disease risk in women.

Sex hormone treatments can increase muscle mass in older adults but have inconsistent effects on muscle function and may carry cardiovascular risks.

Finasteride and minoxidil are effective FDA-approved treatments for androgenetic alopecia.