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30 / 1000+ results![Dihydrotestosterone Stimulates 5a-Reductase Activity in Pubic Skin Fibroblasts*](/images/research/ccfb56ab-33f2-4160-90a2-af617b0b19cb/small/28335.jpg)
research Dihydrotestosterone Stimulates 5a-Reductase Activity in Pubic Skin Fibroblasts*
Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.
![Novel type 1 5a-reductase Inhibitors with Antiproliferative Potential on LNCaP cells](/images/research/7585be92-4c9a-4fc8-ab21-a2f76f984e10/small/31729.jpg)
research Novel type 1 5a-reductase Inhibitors with Antiproliferative Potential on LNCaP cells
New compounds may help treat prostate cancer by reducing cell growth.
![705 Influence of 5a-Reductase Inhibitor (5-ARI) Usage on the Reproductive Function of Married Men](/images/research/b3b8480f-0833-4851-a685-90aad816d371/small/13710.jpg)
research 705 Influence of 5a-Reductase Inhibitor (5-ARI) Usage on the Reproductive Function of Married Men
Finasteride does not negatively affect male reproductive function.
![Increased Scalp Skin and Serum 5a-Reductase Reduced Androgens in a Man Relevant to the Acquired Progressive Kinky Hair Disorder and Developing Androgenetic Alopecia](/images/research/927280aa-7057-44ba-9375-5bb1dc06ea7a/small/2163.jpg)
research Increased Scalp Skin and Serum 5a-Reductase Reduced Androgens in a Man Relevant to the Acquired Progressive Kinky Hair Disorder and Developing Androgenetic Alopecia
Reduced androgens linked to kinky hair disorder and hair loss; 5a-reductase inhibitors may help.
research A New Look at the 5á-Reductase Inhibitor Finasteride
Finasteride, a medication, is being re-evaluated for its effects and uses.
![In Vivo Time-Dependent Inhibition of Human Steroid 5a-Reductase by Finasteride](/images/research/36c05472-2dc1-4fa2-a4ff-51eab03e4d6e/small/2093.jpg)
research In Vivo Time-Dependent Inhibition of Human Steroid 5a-Reductase by Finasteride
Finasteride poorly inhibits type 1 5AR, affecting its effectiveness.
![570 Targeting JAK/STAT and Wnt/b-catenin pathways and 5a-reductase activity to develop an effective anti-hair loss product](/images/research/ddd0a50a-5627-409a-823d-fe4faa021588/small/16806.jpg)
research 570 Targeting JAK/STAT and Wnt/b-catenin pathways and 5a-reductase activity to develop an effective anti-hair loss product
The lotion with specific plant extracts effectively increased hair growth and improved hair cycle in subjects after 3 months.
![In vitro and In vivo Effects of 17β-N-(4-phenylcarbamoyl) androst-4-en-3- one Derivatives as 5a-reductase Inhibitors on Androgen-dependent Glands](/images/research/e7c0a3ce-09ac-4c47-9e06-f91c86a222b9/small/11559.jpg)
research In vitro and In vivo Effects of 17β-N-(4-phenylcarbamoyl) androst-4-en-3- one Derivatives as 5a-reductase Inhibitors on Androgen-dependent Glands
Three compounds were found to inhibit a prostate disease-related enzyme and reduce prostate size more effectively than the current treatment, suggesting they could be used for treating benign prostatic hyperplasia.
![Therapeutic Effect of <i>Nepenthes kampotiana</i> Lecomte Ethanol Extract (Nk-EE) on Androgenic Alopecia through the Inhibition of Apoptosis and 5a-Reductase Activity](/images/research/4d715689-b04c-4615-88c7-cc05d5e6a344/small/12948.jpg)
research Therapeutic Effect of <i>Nepenthes kampotiana</i> Lecomte Ethanol Extract (Nk-EE) on Androgenic Alopecia through the Inhibition of Apoptosis and 5a-Reductase Activity
Nepenthes kampotiana extract can potentially prevent hair loss and could be an effective treatment for common baldness.
![Physiopathological role of the enzymatic complex 5α-reductase and 3α/β-hydroxysteroid oxidoreductase in the generation of progesterone and testosterone neuroactive metabolites](/images/research/87ca3c21-0b49-4fe7-824c-9576c1426899/small/17490.jpg)
research Physiopathological role of the enzymatic complex 5α-reductase and 3α/β-hydroxysteroid oxidoreductase in the generation of progesterone and testosterone neuroactive metabolites
The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.
![Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride](/images/research/da49ac21-d3b0-4cad-b801-ed679a7294de/small/3162.jpg)
research Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride
Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.
![Estudio comparativo de dos complementos alimenticios inhibidores de la 5a-reductasa en la alopecia androgénica femenina](/images/research/a07add51-53dc-4481-a131-8b2b88bffdd0/small/17944.jpg)
research Estudio comparativo de dos complementos alimenticios inhibidores de la 5a-reductasa en la alopecia androgénica femenina
The higher dose supplement was more effective in treating female hair loss.
research Theoretical Evaluation of Twenty-Cannabinoid Derivatives on Either Androgen Receptor or 5α-Reductase Enzyme
Some cannabinoid derivatives may be more effective than current drugs at targeting proteins relevant to prostate cancer treatment.
![Production rates of testosterone and of dihydrotestosterone in female pattern hair loss](/images/research/a3d1c039-7ada-48db-8d24-ab40b7d5863c/small/2478.jpg)
research Production rates of testosterone and of dihydrotestosterone in female pattern hair loss
Women with female-pattern baldness produce more testosterone, but 5a-reductase inhibition treatment won't help.
![Algorithmic approach to the treatment of frontal fibrosing alopecia: A systematic review](/images/research/57a22fd6-2991-45a7-aef4-a903d5843e77/small/11562.jpg)
research Algorithmic approach to the treatment of frontal fibrosing alopecia: A systematic review
The review suggests there's no agreed treatment for Frontal Fibrosing Alopecia, but hydroxychloroquine and 5a-reductase inhibitors are most effective. New treatments like platelet-rich plasma and LED light could help if standard treatments fail.
![Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbiota composition](/images/research/05b4b57b-5a5d-49df-ba0c-90a7c630cd9e/small/4449.jpg)
research Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbiota composition
Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.
![Patients With a Large Prostate Show a Higher Prevalence of Androgenetic Alopecia](/images/research/9eaa97f4-101c-4a63-8e08-4f0967914f78/small/2626.jpg)
research Patients With a Large Prostate Show a Higher Prevalence of Androgenetic Alopecia
Large prostates link to more hair loss.
![Effect of finasteride on the ovulatory function of normal women](/images/research/b64f2d75-a9a9-4183-b3eb-e4f3219809fa/small/2472.jpg)
research Effect of finasteride on the ovulatory function of normal women
Finasteride doesn't affect ovulation in normal women.
![Finasteride in the Treatment of Hirsutism](/images/research/ee2994c8-8947-43d1-bb45-ed90da7cd165/small/2084.jpg)
research Finasteride in the Treatment of Hirsutism
Finasteride reduces hair growth in women with hirsutism and works better with electrolysis.
![Finasteride inhibits the progesterone-induced spike-wave discharges in a genetic model of absence epilepsy](/images/research/b98dc993-a439-46b1-accc-fec8e24da885/small/2477.jpg)
research Finasteride inhibits the progesterone-induced spike-wave discharges in a genetic model of absence epilepsy
Finasteride blocks progesterone's effect on absence seizures in rats.
![Spectrophotometric method for the estimation of finasteride in tablets](/images/research/8e536e68-56c7-43ce-994c-c06933351909/small/2379.jpg)
research Spectrophotometric method for the estimation of finasteride in tablets
A new method accurately measures finasteride in tablets using color change and light absorption.
![A quantitative hair growth assessment in androgenetic alopecia after application of two cosmetic lotions versus 2% topical minoxidil](/images/research/05be6de8-313e-45e3-8d52-bc3cceaa72a7/small/2589.jpg)
research A quantitative hair growth assessment in androgenetic alopecia after application of two cosmetic lotions versus 2% topical minoxidil
Two cosmetic lotions improved hair growth and had better cosmetic effects than 2% minoxidil.
![Advances in the treatment of male androgenetic alopecia: a brief review of finasteride studies.](/images/research/81a91765-fe74-4277-ac73-458edd592afc/small/2352.jpg)
research Advances in the treatment of male androgenetic alopecia: a brief review of finasteride studies.
Finasteride is effective in growing hair and stopping hair loss in men with mild to moderate alopecia.
![UTILIZAÇÃO DE FINASTERIDA NO TRATAMENTO DA HIPERPLASIA PROSTÁTICA BENIGNA – RELATO DE CASO](/images/research/409113d6-fe12-40fb-8553-9c58e9db2c4f/small/31733.jpg)
research UTILIZAÇÃO DE FINASTERIDA NO TRATAMENTO DA HIPERPLASIA PROSTÁTICA BENIGNA – RELATO DE CASO
Finasteride effectively treats BPH but requires continuous use to maintain benefits.
![The Effect of Finasteride in Men with Benign Prostatic Hyperplasia](/images/research/79ea359b-80ea-4d62-8ccf-66ad00c7e164/small/1990.jpg)
research The Effect of Finasteride in Men with Benign Prostatic Hyperplasia
Finasteride effectively treats BPH but may increase sexual dysfunction risk.
![Female Pattern Hair Loss and Androgen Excess: A Report From the Multidisciplinary Androgen Excess and PCOS Committee](/images/research/ea55930e-af01-44c9-b789-193d1d338668/small/4565.jpg)
research Female Pattern Hair Loss and Androgen Excess: A Report From the Multidisciplinary Androgen Excess and PCOS Committee
Use "female pattern hair loss" term, assess androgen excess, treat with minoxidil and other medications if needed.
![Alopecia: unapproved treatments or indications](/images/research/f50849f0-03e0-4867-bcdd-12def8eae8cf/small/25197.jpg)
research Alopecia: unapproved treatments or indications
Many treatments for hair loss lack proper testing and FDA approval, so their effectiveness is uncertain.
![Androgenetic alopecia; drug safety and therapeutic strategies](/images/research/8d6e76e1-9db7-4864-a0e4-bef7d093af26/small/4229.jpg)
research Androgenetic alopecia; drug safety and therapeutic strategies
Personalized treatment with inhibitors, minoxidil, and laser therapy helps hair loss.
![Identification of a new plant extract for androgenic alopecia treatment using a non-radioactive human hair dermal papilla cell-based assay](/images/research/e851faed-5c7c-4e4d-afa7-b2b56cf3dc30/small/3679.jpg)
research Identification of a new plant extract for androgenic alopecia treatment using a non-radioactive human hair dermal papilla cell-based assay
A new plant extract from Avicennia marina could potentially be used to treat common hair loss.