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Dihydrotestosterone treatment can help penis growth in boys with 5α-reductase deficiency but doesn't fully normalize size after puberty.

Testosterone and dihydrotestosterone treatments can help with penile growth in males with 5α-reductase type 2 deficiency, with dihydrotestosterone being more effective in infancy.

No consistent link between genotype and phenotype in 5-α-Reductase type 2 deficiency.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Understanding how DHT works is important for diagnosing and treating hormone-related disorders.

A49T gene variant linked to higher prostate cancer risk, lower hormone levels, and slightly reduced balding risk.

Gene variant linked to prostate cancer, hormone levels, and hair loss.

Finasteride effectively treats male hair loss, improving growth and density.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Testosterone helps human pancreatic cells increase insulin release.

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

5α-Reductase inhibitors can help treat hair loss, acne, and prostate issues by reducing DHT levels.

Finasteride effectively treats enlarged prostate and male baldness, improves symptoms of hirsutism in women, but doesn't work for acne, and may delay prostate cancer progression with few side effects.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Androgenetic alopecia involves genetics, hormones, and can be treated with medications or surgery.

PNU157706 reduced rat sperm movement and fertility without affecting offspring health.

Finasteride doesn't affect ovulation in normal women.

Androgens can both promote and prevent hair growth due to differences in gene expression in hair follicles.