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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.

Inhibitors of the enzyme 5 alpha-reductase could potentially treat disorders like prostate cancer and baldness.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

Using two drugs together, Flutamide and 4-MA, is more effective for blocking male hormones than using each one alone.

Plant-based compounds might be a promising alternative for prostate cancer treatment with fewer side effects.

New chemical compounds were made that effectively block an enzyme linked to prostate growth.

A topical treatment safely and effectively reduced acne by causing targeted cell death in sebaceous glands without side effects.

Dutasteride and finasteride can help increase hair growth gene expression but need further improvement.

New liposome treatment successfully delivers CRISPR to deactivate a key enzyme in androgen-related disorders.

The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.

New treatments for enlarged prostate are being developed, some of which may be more effective than current medications.

Riboflavin 5′-phosphate (FMN) shows potential for treating androgen-related conditions but may be limited in treating prostate cancer.

Androgens and estrogens are crucial for insulin secretion in males.

Finasteride reduces hair loss and treats BPH without major hormone changes, but may cause sexual dysfunction.

Compounds from Angelica koreana roots, especially osthenol, could be effective for treating conditions like prostate disease and hair loss.

New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.

A reliable model for screening type II 5α-reductase inhibitors was created and validated.

Finasteride effectively treats BPH, but needs more trials to understand potential.

Muscles can make their own androgens, which may help muscle growth.

Finasteride affects prostate weights and pituitary activity differently with age.

Androgens may influence bladder cancer progression by affecting cellular behavior.

Ostrich antibodies can help restore hair growth in people with a specific type of hair loss, increasing hair count by 71% on average.

Finasteride reduces sperm count and quality and alters hormone levels in mice.

Understanding how DHT works is important for diagnosing and treating hormone-related disorders.

Liposomes are not better than acetone for applying DHT on skin.

The body's change of testosterone into DHT is not necessary for testosterone's muscle and sexual effects.

Male androgenetic alopecia involves hair follicle miniaturization due to DHT, with potential treatments using inhibitors and blockers.

5-alpha reductase inhibitors, like finasteride and dutasteride, are used for prostate issues, hair loss, and excessive hair growth, may help with COVID-19, but can cause sexual and mental health side effects, and their use in preventing prostate cancer needs more examination.

Teak leaf extract contains compounds that could help treat hair loss.