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The combination of certain vitamins and pumpkin seed oil has not been proven to maintain normal hair.

Kidney stones and hair loss are significantly related in people under 60 years old.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

No effective treatment for frontal fibrosing alopecia was found, but oral 5-alpha-reductase inhibitors had the best response; for lichen planopilaris, topical corticosteroids were commonly used but had a high relapse rate.

5% minoxidil helps hair regrowth in androgenic alopecia.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Some treatments like intralesional steroids and 5α-reductase inhibitors are effective for frontal fibrosing alopecia, but more research is needed.

5-alpha-reductase inhibitors can lower prostate cancer risk but may increase high-grade tumors and cause sexual side effects.

Use 5% minoxidil or oral finasteride for mild-to-moderate hair loss, combine with hair transplant for severe cases.

Women with PCOS have higher 5α-reductase activity, which may be linked to insulin resistance.

The new progesterone derivatives effectively inhibit 5α-reductase and bind to the androgen receptor.

Androgenetic alopecia is a common hair loss condition caused by testosterone effects on hair follicles, leading to thinner, shorter, and less pigmented hair, diagnosed using scalp dermoscopy and treated with topical minoxidil, antiandrogen agents, and 5-alpha reductase inhibitors.

Home-use microneedle devices might safely boost 5% minoxidil's effectiveness for hair growth.

Spironolactone works well for acne and hirsutism, isotretinoin is very effective for acne and may have antiandrogenic effects, and 5 alpha-reductase inhibitors should be considered antiandrogens.

Using 5-butylpicolinate esters improves the sensitivity and reliability of detecting testosterone and dihydrotestosterone in saliva.

Women pay more for the same 5% minoxidil foam than men, but prices for liquid solutions are similar.

Finasteride, when taken daily, lowers dihydrotestosterone levels but doesn't noticeably affect adrenal steroid production, except by blocking the 5 alpha-reductase enzyme.

Men taking 5-alpha reductase inhibitors for prostate issues may be less likely to experience severe COVID-19, but it doesn't prevent ICU admission or death.

Most care for benign prostatic hyperplasia follows guidelines, but 5-α reductase inhibitors are often used incorrectly.

Certain medications, especially 5-α reductase inhibitors and neuropsychiatric drugs, are often linked to erectile dysfunction.

Microneedling helps with hair loss, especially with 5% minoxidil, but more high-quality research is needed.

The authors suggest that 5-α-reductase inhibitors, like dutasteride, are effective in treating frontal fibrosing alopecia and should be the first-line treatment, with other options for severe cases. They also recommend further research on Janus kinase inhibitors.

Intralesional chemotherapy with 5-fluorouracil and methotrexate may worsen keratoacanthoma-type skin cancer in transplant patients.

Best treatment for Frontal Fibrosing Alopecia is 5-alpha-reductase inhibitors and intralesional corticosteroids.

Taking 5-alpha reductase inhibitors does not increase breast cancer risk in men.

The seed extract of Lepidium sativum L. can potentially treat hair loss, showing effects similar to 5% minoxidil.

Certain medications, especially 5-alpha reductase inhibitors, are commonly linked to erectile dysfunction.