66 citations,
July 2015 in “Organogenesis” Wnt signaling is crucial for skin wound healing and reducing scars.
64 citations,
September 2019 in “Circulation” ADT, especially enzalutamide, may increase the risk of heart rhythm problems and sudden death in men.
54 citations,
April 2010 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism” Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.
52 citations,
October 1999 in “Developmental Dynamics” Mutations in the hairless gene in mice affect its expression and lead to a range of developmental issues in multiple tissues.
46 citations,
June 2015 in “Journal of Investigative Dermatology” Androgen receptor activity blocks Wnt/β-catenin signaling, affecting hair growth and skin cell balance.
44 citations,
June 2012 in “Endocrinology” High levels of androgens during early development may cause PCOS-like symptoms.
41 citations,
November 2008 in “The American journal of pathology” Blocking a specific protein signal can make hair grow on mouse nipples.
41 citations,
June 2007 in “Steroids” New methods to make oxasteroids show promise for medical treatments like osteoporosis and breast cancer.
37 citations,
April 2002 in “The American Journal of Medicine” St. John's Wort can cause dangerous high blood pressure if taken with certain foods.
29 citations,
August 2005 in “Biopolymers” L-cysteine slows down the breaking of bonds in hair due to electrostatic interactions.
28 citations,
February 2020 in “Clinical Ophthalmology” Certain medications and patient factors increase the risk of Intraoperative Floppy Iris Syndrome during cataract surgery, but with careful planning and technique adjustments, complications can be minimized.
28 citations,
August 2015 in “Journal of Drug Targeting” The new CoQ10 gel protects mouse skin better against aging from UV light than the old gel.
26 citations,
January 2013 in “BioMed Research International” Hormonal changes after childbirth and menopause can lead to women's hair loss and facial hair growth, with a need for better treatments.
24 citations,
July 2011 in “British Journal of Dermatology” Men with hair loss have more DNA changes in back-of-head hair follicles, possibly protecting them from thinning.
23 citations,
April 2017 in “Clinical, Cosmetic and Investigational Dermatology” Dermatologists should screen for and manage psychological issues in patients with skin conditions to improve their quality of life.
17 citations,
August 2015 in “Expert Opinion on Pharmacotherapy” The document concludes that oral finasteride and topical minoxidil are effective for genetic hair loss, while other treatments for different types of hair loss show promise but need more research.
16 citations,
October 2014 in “Cell death and disease” FoxN1 overexpression in young mice harms immune cell and skin development.
16 citations,
August 2007 in “Histopathology” A woman's rare adrenal tumor caused high testosterone and cortisol levels, which normalized after the tumor was removed.
15 citations,
June 2015 in “Lasers in Medical Science” The 830-nm wavelength was most effective at promoting hair growth in rats using low-level laser therapy.
12 citations,
November 2014 in “Bioscience, Biotechnology, and Biochemistry” Genetically modifying a bacteria and changing its growth conditions significantly increased the production of a chemical called dipicolinic acid.
9 citations,
January 2007 in “Gynecological Endocrinology” A woman was the first known case to have both polycystic ovary syndrome and autoimmune polyglandular syndrome type 2, suggesting a need to check for both conditions in similar patients.
8 citations,
March 2014 in “Dermatologic Clinics” Specialized techniques are needed for hair restoration in individuals with curly Afrocentric hair due to unique challenges.
8 citations,
December 1981 in “Journal of The American Academy of Dermatology” The document concludes that parathyroid diseases have a range of clinical features and outcomes, with some conditions being treatable and others having a high risk of mortality.
7 citations,
July 2019 in “Advances in preventive medicine” Most diabetic patients have skin problems, which are more common with longer diabetes duration and poor blood sugar control.
7 citations,
July 2017 in “Australasian Journal of Dermatology” Reflectance confocal microscopy is useful for diagnosing scalp melanomas, which have features similar to those on the trunk.
7 citations,
December 2008 in “Expert Review of Dermatology” The document concludes that various childhood hair and nail disorders exist, some may improve on their own, and advances in genetics and immunology could enhance treatment and counseling.
5 citations,
March 2015 in “Methods” The document explains how to create detailed biological pathways using genomic data and tools, with examples of hair and breast development.
4 citations,
March 2014 in “The FASEB Journal” The HIF-2α/ARNT complex is important for hair follicle development by controlling cell growth.
3 citations,
July 1987 in “Dermatologic Clinics” Scalp reduction can treat severe hair loss, but success depends on scalp flexibility and it may cause complications like pain, infection, and cosmetic issues.
2 citations,
April 2019 in “Plastic and Reconstructive Surgery” The letter suggests that a modified fat processing technique may increase regenerative cells but calls for more trials to confirm its effectiveness for skin and hair treatments.