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5-Alpha reductase inhibitors may prevent prostate cancer but are not widely used due to concerns about trial relevance and potential risks, and more research is needed to confirm long-term benefits.

Starting 5-alpha reductase inhibitors does not significantly increase the risk of rhabdomyolysis in older men, but is linked to a higher risk of muscle conditions.

The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.

Testosterone's muscle-building effects do not require its conversion to DHT.

Men over 66 taking medication for prostate enlargement have a higher risk of depression and self-harm, especially in the first 18 months of treatment.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

High levels of testosterone and 5α-DHT can lead to cell death in cells important for hair growth.

The review suggests younger men taking 1 mg finasteride report more side effects, including sexual, skin, metabolic, and psychological issues.

The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.

Rats had lasting erectile problems after stopping a certain medication.

Combining electrodynamic microneedle with 5% minoxidil improves hair growth and reduces hair loss in Chinese men.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Men taking 5-alpha-reductase inhibitors before or after bladder cancer diagnosis had a lower risk of dying from the disease.

New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.

α-Blockers and 5-ARIs for BPH can cause sexual dysfunction, including erectile and ejaculatory issues.

Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

Using 5-alpha-reductase inhibitors, drugs for prostate issues and hair loss, may lead to eye abnormalities in men.

Using a certain drug on the skin can help prevent hair loss caused by pulling on the hair.

Light therapy reduces scalp inflammation, boosts hair regrowth with Minoxidil 2%.

5-alpha reductase inhibitors can cause sexual, neurologic, endocrine, and cardiovascular side effects, but these are rare and usually stop after ending treatment.

Higher levels of heat shock protein 27 and lower levels of miR-1 can increase AR levels, leading to hair loss in men.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Genes and hormones cause hair loss, with four genes contributing equally.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Green tea component EGCG may help prevent hair loss by changing microRNA levels in certain scalp cells.

A certain gene variant may increase the risk of polycystic ovary syndrome in Chinese women.

Taking 5-Alpha Reductase Inhibitors before bladder removal surgery might make high-grade bladder tumors less aggressive.

Phyllanthus urinaria extract may help treat hair loss by blocking a hair-related enzyme.

Using 5-alpha-reductase inhibitors may improve bladder cancer survival in men.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.