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Dihydrotestosterone (DHT) mainly affects nearby cells, doesn't significantly change prostate hormonal environment or cancer risk, and doesn't play a main role in causing hair loss or acne. More research is needed on its effects on heart health, sexual function, and bone health.

Androgens, male hormones, affect physical and mental functions, with a decrease leading to health issues like muscle loss, bone disease, and depression, and more research is needed on long-term effects and treatments.

Allopregnanolone can reduce gut inflammation and normalize neurotransmitter levels after finasteride withdrawal.

Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.

Statins may help treat PCOS by lowering androgen levels and improving cholesterol.

Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.

Sons of mothers with polycystic ovary syndrome (PCOS) have a higher risk of obesity and insulin resistance, possibly due to certain genes and factors passed down from their mothers.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Researchers created a new, efficient way to make Dutasteride, a hair loss and prostate drug, with high purity using a benzoyl group.

New A-homo-B, 19-dinor steroids showed strong antiandrogenic activity without affecting the enzyme 5α-reductase or androgen receptor binding.

The chemicals 17βC and its methyl ester can block the effects of testosterone on hamster skin but not the effects of DHT.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.

Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.

Spironolactone reduces the enzyme activity that converts testosterone to DHT, helping treat excessive hair growth in women.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

The exact cause of increased 5α-reductase activity leading to hirsutism in women is still unknown.

Finasteride and minoxidil together promote hair growth better than either alone.

5α reductase inhibitors treat hair loss but may cause sexual side effects and risks.

Finasteride reduces dihydrotestosterone, increases testosterone, and may treat hirsutism in women.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

Taking 5-Alpha Reductase Inhibitors before bladder removal surgery might make high-grade bladder tumors less aggressive.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

Using 5-alpha-reductase inhibitors, drugs for prostate issues and hair loss, may lead to eye abnormalities in men.

Finasteride may affect PNMT, causing side effects.

Some women with excess hair growth have a hormone condition that can't be diagnosed by blood or urine tests alone.

5α reductase type 2 enzyme mutation and oxidative stress may increase androgenetic alopecia risk in Egyptians.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.