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    Research 421–450 of 1000+

    1. Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP−Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor Journal of the American Chemical Society · 1996 · 136 citations
    2. Discovery and Clinical Development of Dutasteride, a Potent Dual 5α- Reductase Inhibitor Current topics in medicinal chemistry · 2006 · 58 citations
    3. Inhibitors of 5α-Reductase in the Treatment of Benign Prostatic Hyperplasia Current pharmaceutical design · 2006 · 52 citations
    4. Azasteroids as inhibitors of testosterone 5α-reductase in mammalian skin 1993 · 34 citations
    5. The Effect of 5 -Reductase Inhibitors on Erectile Function International Journal of Andrology · 2008 · 31 citations
    6. Differential expression of steroid 5α-reductase isozymes and association with disease severity and angiogenic genes predict their biological role in prostate cancer Endocrine Related Cancer · 2010 · 30 citations
    7. Sexual dimorphism of growth plate prehypertrophic and hypertrophic chondrocytes in response to testosterone requires metabolism to dihydrotestosterone (DHT) by steroid 5‐alpha reductase type 1 Journal of Cellular Biochemistry · 2005 · 27 citations
    8. The 5α-reductase inhibitor Dutasteride but not Finasteride protects dopamine neurons in the MPTP mouse model of Parkinson’s disease Neuropharmacology · 2015 · 27 citations
    9. Inhibitors of 5α -Reductase Type I in LNCaP Cells from the Roots of Angelica koreana Planta Medica · 2002 · 22 citations
    10. Abietic Acid from Resina Pini of Pinus Species as a Testosterone 5.ALPHA.-Reductase Inhibitor JOURNAL OF HEALTH SCIENCE · 2010 · 21 citations
    11. A new label-free screen for steroid 5α-reductase inhibitors using LC-MS Steroids · 2016 · 15 citations
    12. Equine 5α-reductase activity and expression in epididymis Journal of Endocrinology · 2016 · 14 citations
    13. The 5α-Reductase Inhibitor Finasteride Exerts Neuroprotection Against Ischemic Brain Injury in Aged Male Rats Translational Stroke Research · 2018 · 14 citations
    14. Rat steroid 5α-reductase kinetic characteristics: Extreme pH-dependency of the type II isozyme in prostate and epididymis homogenates The Journal of Steroid Biochemistry and Molecular Biology · 1995 · 13 citations
    15. The 5α-reductase inhibitor finasteride increases suicide-related aggressive behaviors and blocks clozapine-induced beneficial effects in an animal model of schizophrenia Physiology & Behavior · 2018 · 12 citations
    16. Finasteride, A Steroid 5α-Reductase Inhibitor, Does Not Affect the Oxidative Metabolism of Antipyrine The Journal of Clinical Pharmacology · 1993 · 9 citations
    17. The 5α-reductase inhibitor finasteride reduces opioid self-administration in animal models of opioid use disorder Journal of Clinical Investigation · 2021 · 8 citations
    18. 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro The Journal of Steroid Biochemistry and Molecular Biology · 2019 · 7 citations
    19. A 5α-reductase inhibitor, finasteride, increases differentiation and proliferation of embryonal carcinoma cell-derived-neural cells Medical Hypotheses · 2010 · 4 citations
    20. Determination of rat 5α-reductase type 1 isozyme activity and its inhibition by novel steroidal oxazolines Acta Biologica Hungarica · 2010 · 4 citations
    21. A role for steroid 5 alpha-reductase 1 in vascular remodeling during endometrial decidualization Frontiers in endocrinology · 2022 · 4 citations
    22. Design, synthesis and biological evaluation of novel 3-oxo-4-oxa-5α-androst-17β-amide derivatives as dual 5α-reductase inhibitors and androgen receptor antagonists Bioorganic & medicinal chemistry letters · 2017 · 3 citations
    23. The 5α-reductase inhibitor finasteride is not associated with alterations in sleep spindles in men referred for polysomnography Human Psychopharmacology-clinical and Experimental · 2015 · 3 citations
    24. Lipid Profile and 5α-Reductase Inhibition Activity of Proprietary Ultrahigh-Pressure Supercritical Carbon Dioxide and Hexane Saw Palmetto Extracts Uro · 2023 · 2 citations
    25. Pharmacological inhibition of 5α-reductase in androgenetic alopecia: a comparative narrative review of finasteride and dutasteride, with attention to responder heterogeneity and female pattern hair loss Zenodo (CERN European Organization for Nuclear Research) · 2026
    26. Pharmacological inhibition of 5α-reductase in androgenetic alopecia: a comparative narrative review of finasteride and dutasteride, with attention to responder heterogeneity and female pattern hair loss Zenodo (CERN European Organization for Nuclear Research) · 2026
    27. A Role for Steroid 5 alpha-reductase 1 in Vascular Remodelling During Endometrial Decidualisation bioRxiv (Cold Spring Harbor Laboratory) · 2022
    28. Re: Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men with Suppressed Testosterone Production: A Randomized Controlled Trial The Journal of Urology · 2012
    29. Synthesis of 5α-Reductase Special inhibitor Finasteride Journal of Xingtai University · 2009
    30. Novel 5α-reductase inhibitors unlinked to depression-like phenotypes in rat model of BPH The Journal of Steroid Biochemistry and Molecular Biology · 2026