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Scientists created cell lines from balding patients and found that cells from the front of the scalp are more affected by hormones that cause hair loss than those from the back.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

5α-reductase inhibitors and alpha-1 adrenergic antagonists together effectively treat benign prostatic hyperplasia, with long-term benefits.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Hair loss in Androgenetic Alopecia is caused by genetics, aging, and lifestyle, leading to hair follicle shrinkage and related health risks.

Plant extracts like Avicennia marina, Boehmeria nipononivea, and Camellia sinensis could potentially treat hair loss with fewer side effects than synthetic drugs.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Natural 5AR inhibitors effectively improve mild to moderate hair loss in men.

Beta-sitosterol and stigmasterol might help prevent hair loss by blocking a specific enzyme.

Plant extracts effectively reduce hair loss and increase growth, offering a safe alternative treatment.

5-alpha reductase inhibitors, like finasteride and dutasteride, may cause depression, but more research is needed to understand why.

5-alpha reductase inhibitors may help protect the brain and gut in Parkinson's disease.

The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

The document concludes that the risk of sexual side effects from 5-alpha-reductase inhibitors is low and often temporary, but more research is needed on potential permanent effects.

Testosterone's muscle-building effects do not require its conversion to DHT.

Men over 66 taking medication for prostate enlargement have a higher risk of depression and self-harm, especially in the first 18 months of treatment.

Thujae occidentalis semen extract may help treat male pattern baldness by blocking a hair loss-related enzyme and reducing hair loss in mice.

Ficus carica leaf extract may help treat skin disorders by reducing inflammation and androgen effects in skin cells.

Ageratum conyzoides L. extract may effectively and safely treat hair loss.

The enzyme 5α-reductase is key in causing psychotic-like effects from sleep deprivation.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

Saw palmetto extracts might help treat male hair loss and need more research.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Male yak hair growth is influenced by DHT synthesis, which is promoted by 5α-red1 and AR during growth phases, while E2 may inhibit growth through ERα.

Male pattern baldness involves three mechanisms and finasteride can help reverse it.

Tadalafil is effective for treating urinary symptoms in men with BPH.

Suppressing certain hormones might help prevent prostate cancer.

Minoxidil, finasteride, and low-level laser light therapy are effective FDA-approved treatments for hair loss.

Vitamin E affects liver metabolism, enhancing stress resistance, reducing blood clotting, and altering hormone processing.