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    Research 271–300 of 1000+

    1. Inhibition of 5α-Reductase, IL-6 Secretion, and Oxidation Process of Equisetum debile Roxb. ex Vaucher Extract as Functional Food and Nutraceuticals Ingredients Nutrients · 2017 · 49 citations
    2. Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride The Journal of Steroid Biochemistry and Molecular Biology · 2012 · 45 citations
    3. Immunolocalization of 5α-Reductase Isozymes in Acne Lesions and Normal Skin Archives of dermatology · 2000 · 45 citations
    4. Anabolic effects of testosterone are preserved during inhibition of 5α-reductase 2007 · 42 citations
    5. Reduced levels of 5-α reductase 2 in adult prostate tissue and implications for BPH therapy 2011 · 39 citations
    6. Five-alpha-reductase Inhibitors for prostate cancer prevention. The Cochrane library · 2008 · 37 citations
    7. 7 Regulation of androgen receptor and 5α-reductase in the skin of normal and hirsute women Clinics in endocrinology and metabolism · 1986 · 35 citations
    8. <i>Curcuma aeruginosa</i>, a novel botanically derived 5α-reductase inhibitor in the treatment of male-pattern baldness: a multicenter, randomized, double-blind, placebo-controlled study Journal of Dermatological Treatment · 2011 · 34 citations
    9. Long-term Oral Administration of 5α-reductase Inhibitor Attenuates Erectile Function by Inhibiting Autophagy and Promoting Apoptosis of Smooth Muscle Cells in Corpus Cavernosum of Aged Rats Urology · 2013 · 34 citations
    10. Evaluation of 5α-reductase inhibitory activity of certain herbs useful as antiandrogens Andrologia · 2013 · 33 citations
    11. Male Breast Cancer and 5α-Reductase Inhibitors Finasteride and Dutasteride The Journal of Urology · 2013 · 32 citations
    12. Key targets of hormonal treatment of prostate cancer. Part 2: the androgen receptor and 5α-reductase BJU international · 2009 · 29 citations
    13. Exercise activates the PI3K-AKT signal pathway by decreasing the expression of 5α-reductase type 1 in PCOS rats Scientific reports · 2018 · 28 citations
    14. Long-term use of 5α-reductase inhibitors and the risk of male breast cancer Cancer Causes & Control · 2014 · 28 citations
    15. 12 Treatment of hirsutism with 5α-reductase inhibitors Clinics in endocrinology and metabolism · 1986 · 28 citations
    16. Benzo[<i>c</i>]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1 Journal of Medicinal Chemistry · 2000 · 28 citations
    17. Finasteride is the main inhibitor of 5α-reductase activity in microdissected dermal papillae of human hair follicles Archives of Dermatological Research · 1999 · 28 citations
    18. The Neurosteroidogenic Enzyme 5α-Reductase Mediates Psychotic-Like Complications of Sleep Deprivation Neuropsychopharmacology · 2017 · 27 citations
    19. Novel Lead Generation through Hypothetical Pharmacophore Three-Dimensional Database Searching: Discovery of Isoflavonoids as Nonsteroidal Inhibitors of Rat 5α-Reductase Journal of Medicinal Chemistry · 2001 · 27 citations
    20. Inhibitory activities of some traditional Chinese herbs against testosterone 5α-reductase and effects of Cacumen platycladi on hair re-growth in testosterone-treated mice Journal of Ethnopharmacology · 2015 · 25 citations
    21. Different patterns of 5α-reductase expression, cellular distribution, and testosterone metabolism in human follicular dermal papilla cells Biochemical and Biophysical Research Communications · 2008 · 22 citations
    22. Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase Tetrahedron Letters · 1995 · 20 citations
    23. Bladder Cancer Survival of Men Receiving 5α-Reductase Inhibitors The Journal of Urology · 2018 · 20 citations
    24. Novel 5α-Reductase Inhibitors:  Synthesis, Structure−Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids Journal of Medicinal Chemistry · 2005 · 18 citations
    25. Geranylated Coumarins From Thai Medicinal Plant Mammea siamensis With Testosterone 5α-Reductase Inhibitory Activity Frontiers in Chemistry · 2020 · 17 citations
    26. Development of a new gas chromatography–mass spectrometry (GC–MS) methodology for the evaluation of 5α-reductase activity Talanta · 2013 · 17 citations
    27. Synthesis and biological evaluation of novel unsaturated carboxysteroids as human 5α-reductase inhibitors: A legitimate approach European journal of medicinal chemistry · 2012 · 17 citations
    28. Synthesis and biological evaluation of 3-tetrazolo steroidal analogs: Novel class of 5α-reductase inhibitors Bioorganic & Medicinal Chemistry · 2015 · 17 citations
    29. The new paradigm for androgenetic alopecia and plant-based folk remedies: 5α-reductase inhibition, reversal of secondary microinflammation and improving insulin resistance Journal of Ethnopharmacology · 2018 · 16 citations
    30. Sexual Dysfunction Related to Drugs: a Critical Review. Part V: α-Blocker and 5-ARI Drugs Pharmacopsychiatry · 2015 · 15 citations