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This study suggests that specific structural features of minoxidil analogs, such as hydrophobic and hydrogen bond field contributions, are key to enhancing lysyl hydroxylase inhibitory activity, which could inform future hair growth treatments.

This structural study reports on the crystal properties of a compound used for treating alopecia, revealing different conformations and nitrogen hybridization in its piperidine rings.

Minoxidil promotes hair growth in male pattern baldness.

This study identified N-acyl arylsulfonamides, particularly N-(Boc-piperidine-4-carbonyl)-benzenesulfonamides, as steroid sulfatase inhibitors with improved cellular potency compared to previous compounds.

This study suggests that 2% minoxidil and Kerium may promote hair regrowth in rats, while Aminexil showed the least effect among tested treatments; human-use products varied in efficacy in this animal model.

This study identified a new minoxidil analogue called triaminodil in an illegal hair-growth supplement, but no data on its chemical, toxicological, or pharmacological properties are available yet.

This study found that the deletion of soluble epoxide hydrolase (sEH) in mice altered the hair follicle cycle and increased hair growth through effects on hair follicle stem and matrix cells.

This study synthesized and characterized new 2-hydroxypyrrolidine/piperidine derivatives using FeCl₃·6H₂O as a catalyst, but it reports no biological or clinical results.

This study found that the ALAVAX complex, containing 5-ALA and GHK peptide, may increase hair count in male pattern hair loss patients over 6 months without adverse events.

This review discusses the potential uses of 5α-reductase inhibitors for conditions ranging from benign prostatic hyperplasia to skin disorders like acne and male pattern baldness, but it reports no new clinical results.

This study found that dutasteride reduced β-amyloid plaque load in a cerebral amyloidosis model, seemingly linked to mitochondrial apoptosis and autophagy processes.

Made 8 minoxidil samples; 1 cocrystal, 7 salts formed.

This article describes the synthesis of novel polyamine-modified minoxidil analogs and conjugates to potentially enhance minoxidil's biological activity, selectivity, and water solubility, but reports no new biological results.

Certain skin drugs and topical agents, including some natural extracts and fragrances, can cause allergic reactions. Some hair dyes and extensions, as well as minoxidil, a hair growth treatment, can also cause allergies. Botulinum toxin A can effectively reduce sweat but may have temporary side effects.

This study found that a sub-fraction of Noni fruit, FEA-3, showed hair growth-promoting effects in a rabbit model of androgenic alopecia, similar to Minoxidil.

Minoxidil reacts to nitrosation 7 times more than phenol, mainly due to its -NH₂ groups, leading to the creation of N-nitrosominoxidil.

This study reported that CoFe2O4 magnetic nanoparticles efficiently catalyzed the synthesis of minoxidil from 2,6-diamino-4-chloro-pyrimidine N-oxide, achieving a 95% yield with sustained reusability.

This study reports a method for efficiently synthesizing chromeno-pyrimidine-N-oxides in good to excellent yields, confirmed by X-ray analysis, through a reaction between 4-chloro-3-formylcoumarin and aromatic carboximide oximes.

This study found that VEGF activated and minoxidil differentially modulated arachidonic acid metabolite production in hair dermal papilla cells, enhancing PGE2 and LTB4 but reducing PG6KF1α.

This study identified seven new compounds from the plant Sansevieria trifasciata Prain and predicted that four of them may have better anti-alopecia activity than minoxidil through an in silico approach.

Minoxidil with propranolol and diuretics lowers blood pressure but causes fluid retention and hair growth.

This study found that 2% minoxidil solution significantly increased non-vellus hair counts and regrowth rates compared to placebo in men with early androgenic alopecia, suggesting it is an effective treatment.

This study found that lavender oil significantly promoted hair growth in female C57BL/6 mice by increasing hair follicle number, depth, and dermal thickness, while reducing mast cell numbers.

Minoxidil quickly leaves blood, turns into urine metabolites, and has lasting blood pressure-lowering effects.

The researchers reported that reactive oxygen species regulate the stress-induced SP-Mast cell pathway, which might support using antioxidants to treat stress-related hair loss.

This review discusses recent advancements in hair rejuvenation strategies and assesses the potential of herbal drugs as safer alternatives, but reports no new clinical results.

This study in rats found that a new hydroxypropyl-β-cyclodextrin formulation of minoxidil reduced the adverse cardiovascular and proliferative effects seen with traditional minoxidil solutions.

This study found that a specific amino-pyridine compound showed potent androgen receptor antagonist activity, stimulating hair growth in mice and reducing sebum production in a hamster model.

In this study, Indonesian spices were screened in silico for their potential to inhibit MMP9 and TNFα, which are involved in chronic diabetic wounds, and procyanidin was identified as the most promising therapeutic candidate due to its low binding energy to both proteins.

In this study, treatment with DHEA induced mild to moderate hyperplasia of sebaceous glands in ovariectomized rats, which was prevented by the antiandrogen Flutamide but not by the antiestrogen EM-800.