In this descriptive retrospective study, researchers reported that low-dose oral minoxidil (0.25-5mg/day) for androgenic alopecia demonstrated a good safety profile, with 84.4% of 641 patients experiencing no adverse effects and only 1.4% discontinuing due to side effects that resolved with dose reduction or withdrawal.
14 citations
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October 2019 in “Journal of Cellular Physiology” This study found that dermis micrografting improved hair growth and density in patients with androgenetic alopecia over 4, 6, and 12 months, suggesting it could be a novel treatment option.
18 citations
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January 1976 in “Clinical Science” This study found that minoxidil significantly reduced supine diastolic pressure in 94% of patients with severe essential hypertension within 4 weeks, but some patients experienced side effects such as increased hair growth and fatigue.
4 citations
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January 2009 in “Eclética Química” This study described a potentiometric titration method for determining minoxidil, which showed recoveries of 97.4 to 98.7% and agreed with chromatographic results within a 90% confidence level.
May 2026 in “Journal of the American Academy of Dermatology” This study investigated the effectiveness of combining microneedling with 2% topical minoxidil in women with mild-to-moderate androgenetic alopecia and found that adding microneedling every 2 or 4 weeks did not enhance outcomes compared to using minoxidil alone over 24 weeks.
In this randomized, controlled trial, the researchers observed that sub-lingual minoxidil at doses of 1.35 mg and 4.05 mg, but not 0.45 mg, significantly increased hair fibre diameter in men with male androgenetic alopecia over 24 weeks, suggesting a dose-dependent reversal of follicle miniaturization.
June 2024 in “Research Square (Research Square)” This study observed that combining botulinum toxin type A with Minoxidil significantly promoted hair growth, improved quality of life, and enhanced patient satisfaction in male androgenetic alopecia patients at 4 and 6 months, with no adverse effects compared to using Minoxidil alone.
January 2024 in “Pediatric Dermatology” This case study found that a 9-year-old girl with trichorhinophalangeal syndrome type 1 experienced significant improvements in hair density and length after 4 months of topical minoxidil treatment, suggesting its therapeutic potential for this condition.
This study found that sFRP4 inhibits but does not block hair follicle regeneration in mice, suggesting a potential role in treating hair follicle regeneration disorders.
December 2015 in “OPAL (Open@LaTrobe) (La Trobe University)” This study found that minoxidil sulfate enhanced hair growth in CRF-OE mice, with increased hair growth scores observed at 2 and 4 weeks after treatment.
13 citations
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September 2005 in “Eclética Química” This study found that a photometric flow titration using KMnO4 and minoxidil provided results comparable to a chromatographic procedure, with recoveries between 97.6% and 102.8% and relative errors of 3.5% to 4.0%.
5 citations
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January 2012 in “Biological & Pharmaceutical Bulletin” This study found that extract of Hura crepitans inhibited androgen-accelerated NT-4 activity and ameliorated the retardation of hair regrowth in dihydrotestosterone-implanted mice, suggesting a potential role for NT-4 inhibitors in AGA.
September 2023 in “PubMed” In this study, researchers found that platelet-rich plasma therapy demonstrated significantly higher efficacy than topical minoxidil for treating androgenetic alopecia in a Pakistani population, with a 91.7% negative hair pull rate compared to 69.4% for minoxidil after 12 weeks.
March 2024 in “Journal of Natural Remedies” In this study, an 18-year-old boy with alopecia areata successfully experienced normal and healthy hair regrowth after 4 months using microneedling with cupping, alongside internal herbal medication and topical oil application, as a cost-effective and less invasive alternative to high-cost hair treatments and transplantation.
252 citations
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March 1998 in “Developmental dynamics” This study suggests that fibroblast growth factors FGF-4, FGF-8, and FGF-9 may play redundant roles as signals in epithelial-mesenchymal interactions during multiple stages of tooth development in mice.
53 citations
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January 1993 in “Biochemical Pharmacology” This study reports a method for efficiently synthesizing chromeno-pyrimidine-N-oxides in good to excellent yields, confirmed by X-ray analysis, through a reaction between 4-chloro-3-formylcoumarin and aromatic carboximide oximes.
42 citations
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June 2019 in “Aging” This study found that treatment with the polyphenolic compound TCQA activated β-catenin, promoting hair regrowth and the initiation of the anagen phase in mice and human dermal papilla cells.
30 citations
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August 2004 in “British Journal of Plastic Surgery” This case study reports that a patient with extensive scalp scarring achieved an excellent cosmetic result when transplanted chest hair grew from an average of 4 cm at transplant to 15 cm after 18 months.
22 citations
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January 2017 in “Dermatology” In this retrospective study, spironolactone improved acne in 86% of patients while showing minimal side effects, suggesting it as a safe treatment option for postadolescent acne with a low risk of short-term adverse effects like hyperkalemia.
17 citations
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January 2009 in “Nippon Ishinkin Gakkai Zasshi” This case report details a 10-year-old boy diagnosed with kerion celsi caused by Microsporum gypseum, successfully treated with itraconazole over 4.5 months.
9 citations
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January 2017 in “Archives of biochemistry and biophysics” In this study, testosterone was reported to increase aquaporin levels and water reabsorption in the kidneys of male rats, potentially leading to higher blood pressure, with effects mitigated by flutamide and finasteride.
2 citations
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May 2023 in “The Journal of Immunology” This animal study observed that treatment with the S1PR modulator NXC736 significantly reduced lesion area and CD8+ T cell infiltration in mice with alopecia areata, suggesting its potential as a promising therapy for the condition.
1 citations
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July 2026 in “Dermatology and Therapy” In this study, JAK inhibitors for treating alopecia areata and atopic dermatitis were generally well tolerated in a real-world setting, with most adverse events being mild or moderate and rare serious cases resembling the general population incidence.
June 2026 in “British Journal of Dermatology” This study found that in men with androgenetic alopecia, a combination therapy of oral dutasteride and minoxidil was well tolerated and resulted in hair stabilization for nearly all participants by month 6, with 71.4% showing improvement by month 9.
October 2025 in “Clinical and Experimental Dermatology” In this retrospective study, researchers reported that low-dose oral minoxidil significantly improved hair density in 60 patients with androgenetic alopecia or telogen effluvium over 4-8 months, as detected through standardized AI-powered imaging.
April 2025 in “International Journal of Research in Dermatology” In this study, a holistic hair treatment regimen significantly increased hair density in men with stages 2-4 male androgenetic alopecia, showing a more effective outcome than minoxidil over six months, and offering an alternative to traditional treatments.
October 2024 in “Annals of Allergy Asthma & Immunology” This case study reports on a 4-year-old girl who developed telogen effluvium, a type of hair loss, after experiencing anaphylactic reactions to cow's milk. The authors highlight this as the first documentation of anaphylaxis potentially triggering telogen effluvium due to physiologic stress.
November 2009 in “Eclética Química” In this study, a potentiometric titration method was developed for determining minoxidil, achieving recoveries of 97.4% to 98.7%, and it showed agreement with a chromatographic procedure at a 90% confidence level.
September 2005 in “Eclética Química” This study demonstrated that a photometric flow titration method using KMnO4 and minoxidil provided recovery rates of 97.6 to 102.8% for commercial samples, with relative errors of 3.5 to 4.0% compared to chromatographic procedures.
January 2004 in “Zhongguo yiyuan yongyao pingjia yu fenxi” This study found that combining tamsulosin with finasteride was the most cost-effective treatment for mild to moderate BPH among the regimens tested.